Maternal high-dose folic acid during pregnancy and risk of asthma in children: an evidence based review
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.32385/rpmgf.v34i2.12400 |
Resumo: | Objective: Maternal supplementation with folic acid has a positive effect on the prevention of neural tube defects. The relationship between high-dose supplementation of folic acid (5mg) and the development of asthma in children is controversial. The aim of this review is to appraise the evidence on the association between the supplementation with high doses of folic acid during pregnancy and the risk of developing asthma in childhood. Data sources: National Guideline Clearinghouse, Canadian Medical Association Practice Guidelines, Cochrane Library, DARE, Bandolier, PubMed and Index of Portuguese Medical Journals. Review method: We searched meta-analyses, systematic reviews, original studies and clinical guidelines published between July/2006 and July/2016 in Portuguese, English, Spanish and French languages, using the MeSH terms: ‘Folic Acid’, ‘Asthma’ and ‘Pregnancy’. The Strength of Recommendation Taxonomy (SORT) scale of the American of Family Physicians was used to assign evidence levels and strength of recommendation grades. Results: Five studies were selected from a total of 29 articles found, including two meta-analyses and three original studies. Results from meta-analyses do not support an association between periconceptional folic acid supplementation and increased risk of developing childhood asthma. However, none of the studies included in the meta-analyses stratified the results according to the dose of folic acid used during pregnancy and risk of asthma. On the other hand, original studies suggest that supplementation with high doses of folic acid during pregnancy may increase the risk of developing asthma in childhood. Conclusions: Evidence on the association between folic acid supplementation during pregnancy and the risk of developing asthma during childhood is controversial. Studies showing results stratified according to the dose of folic acid reveal that high doses (>800mg) are associated with an increased risk of developing childhood asthma (SORT B). |
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Maternal high-dose folic acid during pregnancy and risk of asthma in children: an evidence based reviewSuplementação excessiva com ácido fólico durante a gravidez e desenvolvimento de asma na infância: uma revisão baseada na evidênciaFolic acidAsthmaPregnancyÁcido fólicoAsmaGravidezObjective: Maternal supplementation with folic acid has a positive effect on the prevention of neural tube defects. The relationship between high-dose supplementation of folic acid (5mg) and the development of asthma in children is controversial. The aim of this review is to appraise the evidence on the association between the supplementation with high doses of folic acid during pregnancy and the risk of developing asthma in childhood. Data sources: National Guideline Clearinghouse, Canadian Medical Association Practice Guidelines, Cochrane Library, DARE, Bandolier, PubMed and Index of Portuguese Medical Journals. Review method: We searched meta-analyses, systematic reviews, original studies and clinical guidelines published between July/2006 and July/2016 in Portuguese, English, Spanish and French languages, using the MeSH terms: ‘Folic Acid’, ‘Asthma’ and ‘Pregnancy’. The Strength of Recommendation Taxonomy (SORT) scale of the American of Family Physicians was used to assign evidence levels and strength of recommendation grades. Results: Five studies were selected from a total of 29 articles found, including two meta-analyses and three original studies. Results from meta-analyses do not support an association between periconceptional folic acid supplementation and increased risk of developing childhood asthma. However, none of the studies included in the meta-analyses stratified the results according to the dose of folic acid used during pregnancy and risk of asthma. On the other hand, original studies suggest that supplementation with high doses of folic acid during pregnancy may increase the risk of developing asthma in childhood. Conclusions: Evidence on the association between folic acid supplementation during pregnancy and the risk of developing asthma during childhood is controversial. Studies showing results stratified according to the dose of folic acid reveal that high doses (>800mg) are associated with an increased risk of developing childhood asthma (SORT B).Objetivo: A suplementação materna com ácido fólico tem um efeito positivo na prevenção de defeitos do tubo neural. É controversa a relação entre a suplementação com altas doses de ácido fólico (5mg) e a asma na criança. O objetivo desta revisão é conhecer a evidência da associação entre a suplementação com altas doses de ácido fólico durante a gravidez e o risco de desenvolvimento de asma na infância. Fontes de dados: National Guideline Clearinghouse, Canadian Medical Association Pratice Guidelines, Cochrane Library, DARE, Bandolier, PubMed e Índex de Revistas Médicas Portuguesas. Métodos de revisão: Pesquisa de meta-análises, revisões sistemáticas, estudos originais e normas de orientação clínica publicados entre julho/2006 e julho/2016 nas línguas portuguesa, inglesa, espanhola e francesa, utilizando os termos MeSH: Folic Acid, Asthma e Pregnancy. Foi utilizada a escala SORT (Strength of Recommendation Taxonomy), da American Academy of Family Physicians, para atribuição do nível de evidência e forças de recomendação. Resultados: Foram selecionados cinco estudos de um total de 29 artigos encontrados: duas meta-análises e três estudos originais. As meta-análises não sustentam a associação entre a suplementação periconcecional com ácido fólico e o aumento do risco do desenvolvimento de asma na infância. No entanto, nenhum dos estudos incluídos nas meta-análises estratificam os resultados de acordo com a dose de ácido fólico fornecida à gestante durante a gestação e o risco de asma. Por outro lado, os estudos originais sugerem que a suplementação com altas doses de ácido fólico durante a gravidez pode aumentar o risco de desenvolvimento de asma na infância. Conclusões: A evidência da associação entre a suplementação com ácido fólico durante a gravidez e o risco de desenvolvimento de asma durante a infância é controversa. Os estudos com resultados estratificados por dose de ácido fólico mostraram que altas doses de suplementação (>800mg) estão associadas ao aumento do risco de desenvolvimento de asma na infância (SORT B).Associação Portuguesa de Medicina Geral e Familiar2018-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.32385/rpmgf.v34i2.12400https://doi.org/10.32385/rpmgf.v34i2.12400Portuguese Journal of Family Medicine and General Practice; Vol. 34 No. 2 (2018): Revista Portuguesa de Medicina Geral e Familiar; 89-95Revista Portuguesa de Medicina Geral e Familiar; Vol. 34 Núm. 2 (2018): Revista Portuguesa de Medicina Geral e Familiar; 89-95Revista Portuguesa de Medicina Geral e Familiar; Vol. 34 N.º 2 (2018): Revista Portuguesa de Medicina Geral e Familiar; 89-952182-51812182-517310.32385/rpmgf.v34i2reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://rpmgf.pt/ojs/index.php/rpmgf/article/view/12400https://rpmgf.pt/ojs/index.php/rpmgf/article/view/12400/11424Direitos de Autor (c) 2018 Revista Portuguesa de Medicina Geral e Familiarinfo:eu-repo/semantics/openAccessRamôa, AndreiaCosta, PedroRibeiro, Ana MariaCastro, Stephanie De2024-09-17T12:00:13Zoai:ojs.rpmgf.pt:article/12400Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-17T12:00:13Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Maternal high-dose folic acid during pregnancy and risk of asthma in children: an evidence based review Suplementação excessiva com ácido fólico durante a gravidez e desenvolvimento de asma na infância: uma revisão baseada na evidência |
title |
Maternal high-dose folic acid during pregnancy and risk of asthma in children: an evidence based review |
spellingShingle |
Maternal high-dose folic acid during pregnancy and risk of asthma in children: an evidence based review Ramôa, Andreia Folic acid Asthma Pregnancy Ácido fólico Asma Gravidez |
title_short |
Maternal high-dose folic acid during pregnancy and risk of asthma in children: an evidence based review |
title_full |
Maternal high-dose folic acid during pregnancy and risk of asthma in children: an evidence based review |
title_fullStr |
Maternal high-dose folic acid during pregnancy and risk of asthma in children: an evidence based review |
title_full_unstemmed |
Maternal high-dose folic acid during pregnancy and risk of asthma in children: an evidence based review |
title_sort |
Maternal high-dose folic acid during pregnancy and risk of asthma in children: an evidence based review |
author |
Ramôa, Andreia |
author_facet |
Ramôa, Andreia Costa, Pedro Ribeiro, Ana Maria Castro, Stephanie De |
author_role |
author |
author2 |
Costa, Pedro Ribeiro, Ana Maria Castro, Stephanie De |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Ramôa, Andreia Costa, Pedro Ribeiro, Ana Maria Castro, Stephanie De |
dc.subject.por.fl_str_mv |
Folic acid Asthma Pregnancy Ácido fólico Asma Gravidez |
topic |
Folic acid Asthma Pregnancy Ácido fólico Asma Gravidez |
description |
Objective: Maternal supplementation with folic acid has a positive effect on the prevention of neural tube defects. The relationship between high-dose supplementation of folic acid (5mg) and the development of asthma in children is controversial. The aim of this review is to appraise the evidence on the association between the supplementation with high doses of folic acid during pregnancy and the risk of developing asthma in childhood. Data sources: National Guideline Clearinghouse, Canadian Medical Association Practice Guidelines, Cochrane Library, DARE, Bandolier, PubMed and Index of Portuguese Medical Journals. Review method: We searched meta-analyses, systematic reviews, original studies and clinical guidelines published between July/2006 and July/2016 in Portuguese, English, Spanish and French languages, using the MeSH terms: ‘Folic Acid’, ‘Asthma’ and ‘Pregnancy’. The Strength of Recommendation Taxonomy (SORT) scale of the American of Family Physicians was used to assign evidence levels and strength of recommendation grades. Results: Five studies were selected from a total of 29 articles found, including two meta-analyses and three original studies. Results from meta-analyses do not support an association between periconceptional folic acid supplementation and increased risk of developing childhood asthma. However, none of the studies included in the meta-analyses stratified the results according to the dose of folic acid used during pregnancy and risk of asthma. On the other hand, original studies suggest that supplementation with high doses of folic acid during pregnancy may increase the risk of developing asthma in childhood. Conclusions: Evidence on the association between folic acid supplementation during pregnancy and the risk of developing asthma during childhood is controversial. Studies showing results stratified according to the dose of folic acid reveal that high doses (>800mg) are associated with an increased risk of developing childhood asthma (SORT B). |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.32385/rpmgf.v34i2.12400 https://doi.org/10.32385/rpmgf.v34i2.12400 |
url |
https://doi.org/10.32385/rpmgf.v34i2.12400 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rpmgf.pt/ojs/index.php/rpmgf/article/view/12400 https://rpmgf.pt/ojs/index.php/rpmgf/article/view/12400/11424 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 2018 Revista Portuguesa de Medicina Geral e Familiar info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos de Autor (c) 2018 Revista Portuguesa de Medicina Geral e Familiar |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Associação Portuguesa de Medicina Geral e Familiar |
publisher.none.fl_str_mv |
Associação Portuguesa de Medicina Geral e Familiar |
dc.source.none.fl_str_mv |
Portuguese Journal of Family Medicine and General Practice; Vol. 34 No. 2 (2018): Revista Portuguesa de Medicina Geral e Familiar; 89-95 Revista Portuguesa de Medicina Geral e Familiar; Vol. 34 Núm. 2 (2018): Revista Portuguesa de Medicina Geral e Familiar; 89-95 Revista Portuguesa de Medicina Geral e Familiar; Vol. 34 N.º 2 (2018): Revista Portuguesa de Medicina Geral e Familiar; 89-95 2182-5181 2182-5173 10.32385/rpmgf.v34i2 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817547198112464896 |