In Vivo Effect of a Nisin–Biogel on the Antimicrobial and Virulence Signatures of Canine Oral Enterococci

Detalhes bibliográficos
Autor(a) principal: Cunha, Eva
Data de Publicação: 2023
Outros Autores: Ferreira, Ana Filipa, Valente, Sara, Matos, Alice, Carreira, L.Miguel, Videira, Marta, Chambel, Lélia, Tavares, Luis, Oliveira, Manuela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/27883
Resumo: Research Areas: Infectious Diseases ; Pharmacology & Pharmacy
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spelling In Vivo Effect of a Nisin–Biogel on the Antimicrobial and Virulence Signatures of Canine Oral EnterococciPeriodontal diseaseDogsNisin–biogelEnterococciAntimicrobial resistanceVirulence signaturesResearch Areas: Infectious Diseases ; Pharmacology & PharmacyABSTRACT - Periodontal disease is a relevant oral disease in dogs and nisin–biogel has been previously proposed to be used in its control. Enterococci, as inhabitants of the oral cavity with a high genetic versatility, are a reliable bacterial model for antimicrobial studies. Our goal was to evaluate the in vivo influence of the long-term dental application of the nisin–biogel on the virulence and antimicrobial signatures of canine oral enterococci. Twenty dogs were randomly allocated to one of two groups (treatment group—TG with nisin–biogel dental application, or control group—CG without treatment) and submitted to dental plaque sampling at day 0 and after 90 days (T90). Samples were processed for Enterococcus spp. isolation, quantification, identification, molecular typing and antimicrobial and virulence characterization. From a total of 140 enterococci, molecular typing allowed us to obtain 70 representative isolates, mostly identified as E. faecalis and E. faecium. No significant differences (p > 0.05) were observed in the virulence index of the isolates obtained from samples collected from the TG and CG at T90. At T90, a statistically significant difference (p = 0.0008) was observed in the antimicrobial resistance index between the isolates from the TC and CG. Oral enterococci were revealed to be reservoirs of high resistant and virulent phenotypesMDPIRepositório da Universidade de LisboaCunha, EvaFerreira, Ana FilipaValente, SaraMatos, AliceCarreira, L.MiguelVideira, MartaChambel, LéliaTavares, LuisOliveira, Manuela2023-06-04T20:50:32Z2023-02-252023-02-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/27883engCunha E, Ferreira AF, Valente S, Matos A, Carreira LM, Videira M, Chambel L, Tavares L, Oliveira M. 2023. In Vivo Effect of a Nisin–Biogel on the Antimicrobial and Virulence Signatures of Canine Oral Enterococci. Antibiotics, 12(3):468. DOI: https://doi.org/10.3390/ antibiotics120304682079-638210.3390/ antibiotics12030468info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-06-11T01:30:35Zoai:www.repository.utl.pt:10400.5/27883Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:00:10.454741Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv In Vivo Effect of a Nisin–Biogel on the Antimicrobial and Virulence Signatures of Canine Oral Enterococci
title In Vivo Effect of a Nisin–Biogel on the Antimicrobial and Virulence Signatures of Canine Oral Enterococci
spellingShingle In Vivo Effect of a Nisin–Biogel on the Antimicrobial and Virulence Signatures of Canine Oral Enterococci
Cunha, Eva
Periodontal disease
Dogs
Nisin–biogel
Enterococci
Antimicrobial resistance
Virulence signatures
title_short In Vivo Effect of a Nisin–Biogel on the Antimicrobial and Virulence Signatures of Canine Oral Enterococci
title_full In Vivo Effect of a Nisin–Biogel on the Antimicrobial and Virulence Signatures of Canine Oral Enterococci
title_fullStr In Vivo Effect of a Nisin–Biogel on the Antimicrobial and Virulence Signatures of Canine Oral Enterococci
title_full_unstemmed In Vivo Effect of a Nisin–Biogel on the Antimicrobial and Virulence Signatures of Canine Oral Enterococci
title_sort In Vivo Effect of a Nisin–Biogel on the Antimicrobial and Virulence Signatures of Canine Oral Enterococci
author Cunha, Eva
author_facet Cunha, Eva
Ferreira, Ana Filipa
Valente, Sara
Matos, Alice
Carreira, L.Miguel
Videira, Marta
Chambel, Lélia
Tavares, Luis
Oliveira, Manuela
author_role author
author2 Ferreira, Ana Filipa
Valente, Sara
Matos, Alice
Carreira, L.Miguel
Videira, Marta
Chambel, Lélia
Tavares, Luis
Oliveira, Manuela
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Cunha, Eva
Ferreira, Ana Filipa
Valente, Sara
Matos, Alice
Carreira, L.Miguel
Videira, Marta
Chambel, Lélia
Tavares, Luis
Oliveira, Manuela
dc.subject.por.fl_str_mv Periodontal disease
Dogs
Nisin–biogel
Enterococci
Antimicrobial resistance
Virulence signatures
topic Periodontal disease
Dogs
Nisin–biogel
Enterococci
Antimicrobial resistance
Virulence signatures
description Research Areas: Infectious Diseases ; Pharmacology & Pharmacy
publishDate 2023
dc.date.none.fl_str_mv 2023-06-04T20:50:32Z
2023-02-25
2023-02-25T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/27883
url http://hdl.handle.net/10400.5/27883
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cunha E, Ferreira AF, Valente S, Matos A, Carreira LM, Videira M, Chambel L, Tavares L, Oliveira M. 2023. In Vivo Effect of a Nisin–Biogel on the Antimicrobial and Virulence Signatures of Canine Oral Enterococci. Antibiotics, 12(3):468. DOI: https://doi.org/10.3390/ antibiotics12030468
2079-6382
10.3390/ antibiotics12030468
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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