Disturbed Correlation Between Arterial Resistance and Pulsatility in Glaucoma Patients
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/2296 |
Resumo: | PURPOSE: (i) To investigate whether pulsatility index (PI) and mean flow velocities (MFV) are altered in glaucoma patients. (ii) To evaluate the significance of PI in retrobulbar autoregulation capacity. METHODS: Patients with primary open-angle glaucoma (POAG; n = 49), normal tension glaucoma (NTG; n = 62) and healthy controls (n = 48) underwent colour Doppler imaging measurements of the retrobulbar vasculature. Kruskal-Wallis test was used to compare variables between the three diagnostic groups. Restricted cubic splines were used to determine nonlinearities between the resistive index (RI) and PI correlations. RESULTS: Mean flow velocities (MFV) were lower in both short posterior ciliary arteries (SCPA) and central retinal arteries (CRA) from the two glaucoma groups (p < 0.04 versus healthy controls). No differences were detected in RI or PI in any arteries of the three diagnostic groups (p > 0.08). In healthy individuals, correlations between RI and PI were linear in all arteries. In both POAG and NTG patients, CRA presented a nonlinear curve with a cutpoint at RI 0.77 (p < 0.001) and 0.61 (p = 0.03), respectively, above which the slope increased nearly five- and tenfold (POAG: 1.96 to 10.06; NTG: -0.46-4.06), respectively. A nonlinear correlation in the ophthalmic artery was only observed in NTG patients, with a cutpoint at RI 0.82 (p < 0.001), above which the slope increased from 3.47 to 14.03. CONCLUSIONS: Glaucoma patients do not present the linear relationships between RI and PI observed in healthy individuals. Their nonlinear relations may be indicative of an altered autoregulation and suggest a possible threshold RI could be determined above which autoregulatory disturbances become more relevant. |
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Disturbed Correlation Between Arterial Resistance and Pulsatility in Glaucoma PatientsCHLC OFTBlood Flow VelocityBlood Pressure/physiologyCiliary Arteries/physiologyCiliary Arteries/ultrasonographyGlaucoma, Open-Angle/physiopathologyGlaucoma, Open-Angle/ultrasonographyHomeostasisIntraocular Pressure/physiologyLow Tension Glaucoma/physiopathologyLow Tension Glaucoma/ultrasonographyOphthalmic Artery/physiologyOphthalmic Artery/ultrasonographyPulsatile FlowRegional Blood FlowRetinal Artery/physiologyRetinal Artery/ultrasonographyTonometry, OcularUltrasonography, Doppler, ColorVisual Acuity/physiologyPURPOSE: (i) To investigate whether pulsatility index (PI) and mean flow velocities (MFV) are altered in glaucoma patients. (ii) To evaluate the significance of PI in retrobulbar autoregulation capacity. METHODS: Patients with primary open-angle glaucoma (POAG; n = 49), normal tension glaucoma (NTG; n = 62) and healthy controls (n = 48) underwent colour Doppler imaging measurements of the retrobulbar vasculature. Kruskal-Wallis test was used to compare variables between the three diagnostic groups. Restricted cubic splines were used to determine nonlinearities between the resistive index (RI) and PI correlations. RESULTS: Mean flow velocities (MFV) were lower in both short posterior ciliary arteries (SCPA) and central retinal arteries (CRA) from the two glaucoma groups (p < 0.04 versus healthy controls). No differences were detected in RI or PI in any arteries of the three diagnostic groups (p > 0.08). In healthy individuals, correlations between RI and PI were linear in all arteries. In both POAG and NTG patients, CRA presented a nonlinear curve with a cutpoint at RI 0.77 (p < 0.001) and 0.61 (p = 0.03), respectively, above which the slope increased nearly five- and tenfold (POAG: 1.96 to 10.06; NTG: -0.46-4.06), respectively. A nonlinear correlation in the ophthalmic artery was only observed in NTG patients, with a cutpoint at RI 0.82 (p < 0.001), above which the slope increased from 3.47 to 14.03. CONCLUSIONS: Glaucoma patients do not present the linear relationships between RI and PI observed in healthy individuals. Their nonlinear relations may be indicative of an altered autoregulation and suggest a possible threshold RI could be determined above which autoregulatory disturbances become more relevant.WileyRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEAbegão Pinto, LVandewalle, EStalmans, I2015-10-08T16:07:42Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2296engActa Ophthalmol. 2012 May;90(3):e214-2010.1111/j.1755-3768.2011.02335.xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:36:15Zoai:repositorio.chlc.min-saude.pt:10400.17/2296Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:19:39.831397Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Disturbed Correlation Between Arterial Resistance and Pulsatility in Glaucoma Patients |
title |
Disturbed Correlation Between Arterial Resistance and Pulsatility in Glaucoma Patients |
spellingShingle |
Disturbed Correlation Between Arterial Resistance and Pulsatility in Glaucoma Patients Abegão Pinto, L CHLC OFT Blood Flow Velocity Blood Pressure/physiology Ciliary Arteries/physiology Ciliary Arteries/ultrasonography Glaucoma, Open-Angle/physiopathology Glaucoma, Open-Angle/ultrasonography Homeostasis Intraocular Pressure/physiology Low Tension Glaucoma/physiopathology Low Tension Glaucoma/ultrasonography Ophthalmic Artery/physiology Ophthalmic Artery/ultrasonography Pulsatile Flow Regional Blood Flow Retinal Artery/physiology Retinal Artery/ultrasonography Tonometry, Ocular Ultrasonography, Doppler, Color Visual Acuity/physiology |
title_short |
Disturbed Correlation Between Arterial Resistance and Pulsatility in Glaucoma Patients |
title_full |
Disturbed Correlation Between Arterial Resistance and Pulsatility in Glaucoma Patients |
title_fullStr |
Disturbed Correlation Between Arterial Resistance and Pulsatility in Glaucoma Patients |
title_full_unstemmed |
Disturbed Correlation Between Arterial Resistance and Pulsatility in Glaucoma Patients |
title_sort |
Disturbed Correlation Between Arterial Resistance and Pulsatility in Glaucoma Patients |
author |
Abegão Pinto, L |
author_facet |
Abegão Pinto, L Vandewalle, E Stalmans, I |
author_role |
author |
author2 |
Vandewalle, E Stalmans, I |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Abegão Pinto, L Vandewalle, E Stalmans, I |
dc.subject.por.fl_str_mv |
CHLC OFT Blood Flow Velocity Blood Pressure/physiology Ciliary Arteries/physiology Ciliary Arteries/ultrasonography Glaucoma, Open-Angle/physiopathology Glaucoma, Open-Angle/ultrasonography Homeostasis Intraocular Pressure/physiology Low Tension Glaucoma/physiopathology Low Tension Glaucoma/ultrasonography Ophthalmic Artery/physiology Ophthalmic Artery/ultrasonography Pulsatile Flow Regional Blood Flow Retinal Artery/physiology Retinal Artery/ultrasonography Tonometry, Ocular Ultrasonography, Doppler, Color Visual Acuity/physiology |
topic |
CHLC OFT Blood Flow Velocity Blood Pressure/physiology Ciliary Arteries/physiology Ciliary Arteries/ultrasonography Glaucoma, Open-Angle/physiopathology Glaucoma, Open-Angle/ultrasonography Homeostasis Intraocular Pressure/physiology Low Tension Glaucoma/physiopathology Low Tension Glaucoma/ultrasonography Ophthalmic Artery/physiology Ophthalmic Artery/ultrasonography Pulsatile Flow Regional Blood Flow Retinal Artery/physiology Retinal Artery/ultrasonography Tonometry, Ocular Ultrasonography, Doppler, Color Visual Acuity/physiology |
description |
PURPOSE: (i) To investigate whether pulsatility index (PI) and mean flow velocities (MFV) are altered in glaucoma patients. (ii) To evaluate the significance of PI in retrobulbar autoregulation capacity. METHODS: Patients with primary open-angle glaucoma (POAG; n = 49), normal tension glaucoma (NTG; n = 62) and healthy controls (n = 48) underwent colour Doppler imaging measurements of the retrobulbar vasculature. Kruskal-Wallis test was used to compare variables between the three diagnostic groups. Restricted cubic splines were used to determine nonlinearities between the resistive index (RI) and PI correlations. RESULTS: Mean flow velocities (MFV) were lower in both short posterior ciliary arteries (SCPA) and central retinal arteries (CRA) from the two glaucoma groups (p < 0.04 versus healthy controls). No differences were detected in RI or PI in any arteries of the three diagnostic groups (p > 0.08). In healthy individuals, correlations between RI and PI were linear in all arteries. In both POAG and NTG patients, CRA presented a nonlinear curve with a cutpoint at RI 0.77 (p < 0.001) and 0.61 (p = 0.03), respectively, above which the slope increased nearly five- and tenfold (POAG: 1.96 to 10.06; NTG: -0.46-4.06), respectively. A nonlinear correlation in the ophthalmic artery was only observed in NTG patients, with a cutpoint at RI 0.82 (p < 0.001), above which the slope increased from 3.47 to 14.03. CONCLUSIONS: Glaucoma patients do not present the linear relationships between RI and PI observed in healthy individuals. Their nonlinear relations may be indicative of an altered autoregulation and suggest a possible threshold RI could be determined above which autoregulatory disturbances become more relevant. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012 2012-01-01T00:00:00Z 2015-10-08T16:07:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/2296 |
url |
http://hdl.handle.net/10400.17/2296 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Acta Ophthalmol. 2012 May;90(3):e214-20 10.1111/j.1755-3768.2011.02335.x |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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