White matter lesions by magnetic resonance: an assessment between DWI and T2 FLAIR techniques

Detalhes bibliográficos
Autor(a) principal: Campos, Carla
Data de Publicação: 2013
Outros Autores: Silva, Raquel, Ribeiro, Maria Margarida, Lança, lu
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.25758/set.594
Resumo: Objectives – To determine the sensitivity and specificity of diffusion-weighted (DWI) and Fluid-Attenuated Inversion Recovery (T2 FLAIR) in the evaluation of white matter lesions and to verify what is his extended complement in order to create a set of best practices in the MRI routine of the brain. Methodology – Was carried out a quantitative study with retrospective analysis. From the database, were selected 30 patients, 20 with and 10 without the disease. We obtained a sample of 60 images, including 30-weighted images of T2 FLAIR and 30 of DWI. Using the program Viewdex®, the set of images was observed by three observers. The images were assessed according to seven criteria: visibility, detection, consistency, location, size, margins of the lesion, and diagnostic capability. We used the calculation of sensitivity and specificity by ROC curves, as well as statistical analysis, namely, T-test, Kappa index, and Pearson’s correlation coefficient between the variables under study. Results – The sensitivity and specificity obtained for the weighted T2 FLAIR were higher (0,915 and 0,038 respectively) than the weighting DWI (0.08 and 0.100 respectively). There were no significant population variances. We obtained a high linear correlation between variables with an r value located between 0.8 and 0.99. There was considerable variability among observers. Conclusions – Although the values of sensitivity and specificity for DWI have been lower than expected, we suggest that this sequence should be included in the routine protocol of the brain to help the differential diagnosis with other pathologies.
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spelling White matter lesions by magnetic resonance: an assessment between DWI and T2 FLAIR techniquesLesões da substância branca por ressonância magnética: uma avaliação entre as ponderações DWI e T2 FLAIRDWIT2 FLAIRRessonância magnéticaLesões da substância brancaDiffusionT2 FLAIRMRIWhite matter diseaseObjectives – To determine the sensitivity and specificity of diffusion-weighted (DWI) and Fluid-Attenuated Inversion Recovery (T2 FLAIR) in the evaluation of white matter lesions and to verify what is his extended complement in order to create a set of best practices in the MRI routine of the brain. Methodology – Was carried out a quantitative study with retrospective analysis. From the database, were selected 30 patients, 20 with and 10 without the disease. We obtained a sample of 60 images, including 30-weighted images of T2 FLAIR and 30 of DWI. Using the program Viewdex®, the set of images was observed by three observers. The images were assessed according to seven criteria: visibility, detection, consistency, location, size, margins of the lesion, and diagnostic capability. We used the calculation of sensitivity and specificity by ROC curves, as well as statistical analysis, namely, T-test, Kappa index, and Pearson’s correlation coefficient between the variables under study. Results – The sensitivity and specificity obtained for the weighted T2 FLAIR were higher (0,915 and 0,038 respectively) than the weighting DWI (0.08 and 0.100 respectively). There were no significant population variances. We obtained a high linear correlation between variables with an r value located between 0.8 and 0.99. There was considerable variability among observers. Conclusions – Although the values of sensitivity and specificity for DWI have been lower than expected, we suggest that this sequence should be included in the routine protocol of the brain to help the differential diagnosis with other pathologies.Objetivos – Determinar a sensibilidade e especificidade das ponderações Difusão (DWI) e T2 Fluid-Attenuated Inversion Recovery (FLAIR) na avaliação de lesões da substância branca (SB) e verificar em que medida se complementam, por forma a criar um conjunto de boas práticas na RM cranioencefálica de rotina. Metodologia – Recorrendo-se a uma metodologia quantitativa, efetuou-se uma análise retrospetiva da qual foram selecionados 30 pacientes, 10 sem patologia e 20 com patologia (2 com EM, 7 com Leucoencefalopatia, 6 com doença microangiopática e 5 com patologia da substância branca indefinida). Obteve-se uma amostra de 60 imagens, nomeadamente: 30 imagens ponderadas em DWI e 30 em T2 FLAIR. Recorrendo ao programa Viewdex®, três observadores avaliaram um conjunto de imagens segundo sete critérios: visibilidade, deteção, homogeneidade, localização, margens e dimensões da lesão e capacidade de diagnóstico. Com os resultados obtidos recorreu-se ao cálculo de sensibilidade e especificidade pelas Curvas ROC, bem como à análise estatística, nomeadamente, Teste-T, Índice de Concordância Kappa e coeficiente de correlação de Pearson entre as variáveis em estudo. Resultados – Os resultados de sensibilidade e de especificidade obtidos para a ponderação T2 FLAIR foram superiores (0,915 e 0,038, respetivamente) aos da ponderação DWI (0,08 e 0,100, respetivamente). Não se verificaram variâncias populacionais significativas. Obteve-se uma elevada correlação linear entre as variáveis com um valor r situado entre 0,8 e 0,99. Verificou-se também uma variabilidade considerável entre os observadores. Conclusões – Dados os baixos valores de sensibilidade e especificidade obtidos para a DWI, sugere-se que esta deva ser incluída no protocolo de rotina de crânio como auxiliar no diagnóstico diferencial com outras patologias.Escola Superior de Tecnologia da Saúde de Lisboa (Instituto Politécnico de Lisboa)2013-05-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.25758/set.594oai:journals.ipl.pt:article/666Saúde e Tecnologia; No. 09 (2013): Maio 2013; 16-23Saúde & Tecnologia; N.º 09 (2013): Maio 2013; 16-231646-9704reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://journals.ipl.pt/stecnologia/article/view/666https://doi.org/10.25758/set.594https://journals.ipl.pt/stecnologia/article/view/666/559Direitos de Autor (c) 2022 Saúde & Tecnologiainfo:eu-repo/semantics/openAccessCampos, CarlaSilva, RaquelRibeiro, Maria MargaridaLança, lu2022-12-20T10:59:14Zoai:journals.ipl.pt:article/666Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:21:28.439142Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv White matter lesions by magnetic resonance: an assessment between DWI and T2 FLAIR techniques
Lesões da substância branca por ressonância magnética: uma avaliação entre as ponderações DWI e T2 FLAIR
title White matter lesions by magnetic resonance: an assessment between DWI and T2 FLAIR techniques
spellingShingle White matter lesions by magnetic resonance: an assessment between DWI and T2 FLAIR techniques
Campos, Carla
DWI
T2 FLAIR
Ressonância magnética
Lesões da substância branca
Diffusion
T2 FLAIR
MRI
White matter disease
title_short White matter lesions by magnetic resonance: an assessment between DWI and T2 FLAIR techniques
title_full White matter lesions by magnetic resonance: an assessment between DWI and T2 FLAIR techniques
title_fullStr White matter lesions by magnetic resonance: an assessment between DWI and T2 FLAIR techniques
title_full_unstemmed White matter lesions by magnetic resonance: an assessment between DWI and T2 FLAIR techniques
title_sort White matter lesions by magnetic resonance: an assessment between DWI and T2 FLAIR techniques
author Campos, Carla
author_facet Campos, Carla
Silva, Raquel
Ribeiro, Maria Margarida
Lança, lu
author_role author
author2 Silva, Raquel
Ribeiro, Maria Margarida
Lança, lu
author2_role author
author
author
dc.contributor.author.fl_str_mv Campos, Carla
Silva, Raquel
Ribeiro, Maria Margarida
Lança, lu
dc.subject.por.fl_str_mv DWI
T2 FLAIR
Ressonância magnética
Lesões da substância branca
Diffusion
T2 FLAIR
MRI
White matter disease
topic DWI
T2 FLAIR
Ressonância magnética
Lesões da substância branca
Diffusion
T2 FLAIR
MRI
White matter disease
description Objectives – To determine the sensitivity and specificity of diffusion-weighted (DWI) and Fluid-Attenuated Inversion Recovery (T2 FLAIR) in the evaluation of white matter lesions and to verify what is his extended complement in order to create a set of best practices in the MRI routine of the brain. Methodology – Was carried out a quantitative study with retrospective analysis. From the database, were selected 30 patients, 20 with and 10 without the disease. We obtained a sample of 60 images, including 30-weighted images of T2 FLAIR and 30 of DWI. Using the program Viewdex®, the set of images was observed by three observers. The images were assessed according to seven criteria: visibility, detection, consistency, location, size, margins of the lesion, and diagnostic capability. We used the calculation of sensitivity and specificity by ROC curves, as well as statistical analysis, namely, T-test, Kappa index, and Pearson’s correlation coefficient between the variables under study. Results – The sensitivity and specificity obtained for the weighted T2 FLAIR were higher (0,915 and 0,038 respectively) than the weighting DWI (0.08 and 0.100 respectively). There were no significant population variances. We obtained a high linear correlation between variables with an r value located between 0.8 and 0.99. There was considerable variability among observers. Conclusions – Although the values of sensitivity and specificity for DWI have been lower than expected, we suggest that this sequence should be included in the routine protocol of the brain to help the differential diagnosis with other pathologies.
publishDate 2013
dc.date.none.fl_str_mv 2013-05-15
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://doi.org/10.25758/set.594
oai:journals.ipl.pt:article/666
url https://doi.org/10.25758/set.594
identifier_str_mv oai:journals.ipl.pt:article/666
dc.language.iso.fl_str_mv por
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dc.relation.none.fl_str_mv https://journals.ipl.pt/stecnologia/article/view/666
https://doi.org/10.25758/set.594
https://journals.ipl.pt/stecnologia/article/view/666/559
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2022 Saúde & Tecnologia
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos de Autor (c) 2022 Saúde & Tecnologia
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Escola Superior de Tecnologia da Saúde de Lisboa (Instituto Politécnico de Lisboa)
publisher.none.fl_str_mv Escola Superior de Tecnologia da Saúde de Lisboa (Instituto Politécnico de Lisboa)
dc.source.none.fl_str_mv Saúde e Tecnologia; No. 09 (2013): Maio 2013; 16-23
Saúde & Tecnologia; N.º 09 (2013): Maio 2013; 16-23
1646-9704
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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