Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproduction

Detalhes bibliográficos
Autor(a) principal: Castro,Raquel Vaz de
Data de Publicação: 2023
Outros Autores: Faustino,Joana, Ferreira,Florbela, Sampaio,Lurdes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000200103
Resumo: Abstract Depending on the age of onset, the excessive release of growth hormone (GH) − most commonly by a pituitary tumor − and subsequently of insulin-like growth factor 1 (IGF1) can cause acromegaly and gigantism. The purpose of this study was to describe the clinical manifestations and main known causes of GH overproduction. GH-releasing hormone and IGF1 can result in a series of physical traits and comorbidities due to hormonal imbalance and somatic overgrowth. To date, several syndromes and genetic mutations have been linked to the etiology of acromegaly.
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spelling Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproductionacromegalygigantismcauseclinical featureAbstract Depending on the age of onset, the excessive release of growth hormone (GH) − most commonly by a pituitary tumor − and subsequently of insulin-like growth factor 1 (IGF1) can cause acromegaly and gigantism. The purpose of this study was to describe the clinical manifestations and main known causes of GH overproduction. GH-releasing hormone and IGF1 can result in a series of physical traits and comorbidities due to hormonal imbalance and somatic overgrowth. To date, several syndromes and genetic mutations have been linked to the etiology of acromegaly.Centro Hospitalar do Porto2023-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000200103Nascer e Crescer v.32 n.2 2023reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000200103Castro,Raquel Vaz deFaustino,JoanaFerreira,FlorbelaSampaio,Lurdesinfo:eu-repo/semantics/openAccess2024-02-06T17:06:37Zoai:scielo:S0872-07542023000200103Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:19:54.344304Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproduction
title Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproduction
spellingShingle Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproduction
Castro,Raquel Vaz de
acromegaly
gigantism
cause
clinical feature
title_short Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproduction
title_full Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproduction
title_fullStr Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproduction
title_full_unstemmed Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproduction
title_sort Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproduction
author Castro,Raquel Vaz de
author_facet Castro,Raquel Vaz de
Faustino,Joana
Ferreira,Florbela
Sampaio,Lurdes
author_role author
author2 Faustino,Joana
Ferreira,Florbela
Sampaio,Lurdes
author2_role author
author
author
dc.contributor.author.fl_str_mv Castro,Raquel Vaz de
Faustino,Joana
Ferreira,Florbela
Sampaio,Lurdes
dc.subject.por.fl_str_mv acromegaly
gigantism
cause
clinical feature
topic acromegaly
gigantism
cause
clinical feature
description Abstract Depending on the age of onset, the excessive release of growth hormone (GH) − most commonly by a pituitary tumor − and subsequently of insulin-like growth factor 1 (IGF1) can cause acromegaly and gigantism. The purpose of this study was to describe the clinical manifestations and main known causes of GH overproduction. GH-releasing hormone and IGF1 can result in a series of physical traits and comorbidities due to hormonal imbalance and somatic overgrowth. To date, several syndromes and genetic mutations have been linked to the etiology of acromegaly.
publishDate 2023
dc.date.none.fl_str_mv 2023-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000200103
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000200103
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000200103
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Centro Hospitalar do Porto
publisher.none.fl_str_mv Centro Hospitalar do Porto
dc.source.none.fl_str_mv Nascer e Crescer v.32 n.2 2023
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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