Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite

Detalhes bibliográficos
Autor(a) principal: Leitão, Alexandre F.
Data de Publicação: 2013
Outros Autores: Gupta, Swati, Silva, João P., Reviakine, I., Gama, F. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/25531
Resumo: Bacterial cellulose (BC) has been suggested to be a suitable biomaterial for the development of cardiovascular grafts. The combination of BC with polyvinyl alcohol (PVA) results in nanocomposites with improved properties. Surprisingly, there are very few studies on the BC–blood interaction. This is the focus of this paper. We present the first thorough assessment of the hemocompatibility of the BC/PVA nanocomposite. Whole blood clotting time, plasma recalcification, Factor XII activation, platelet adhesion and activation, hemolytic index and complement activation are all determined. The platelet activation profiles on BC and BC/PVA surfaces are comprehensively characterized. BC and BC/PVA outperformed ePTFE – used as a point of comparison – thus evidencing their suitability for cardiovascular applications.
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spelling Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocompositeBacterial celluloseBiocompatibilityBiomaterialsPolyvinyl alcoholPlateletsHemocompatibilityScience & TechnologyBacterial cellulose (BC) has been suggested to be a suitable biomaterial for the development of cardiovascular grafts. The combination of BC with polyvinyl alcohol (PVA) results in nanocomposites with improved properties. Surprisingly, there are very few studies on the BC–blood interaction. This is the focus of this paper. We present the first thorough assessment of the hemocompatibility of the BC/PVA nanocomposite. Whole blood clotting time, plasma recalcification, Factor XII activation, platelet adhesion and activation, hemolytic index and complement activation are all determined. The platelet activation profiles on BC and BC/PVA surfaces are comprehensively characterized. BC and BC/PVA outperformed ePTFE – used as a point of comparison – thus evidencing their suitability for cardiovascular applications.Funding for this work was made possible by the FCT fund-ing through the project PTDC/EBB-EBI/112170/2009, FCT PhDgrant (SFRH/BD/66094/2009) and COST-Short Term Mission (COST-STSM-TD1003-8978). Additionally, funding from the Departmentof Industry of the Basque Government program ETORTEK and fromthe Spanish Ministry of Science and Innovation (basic researchgrant CTQ2009-11245 to IR) are also gratefully acknowledged.ElsevierElsevier BVUniversidade do MinhoLeitão, Alexandre F.Gupta, SwatiSilva, João P.Reviakine, I.Gama, F. M.20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/25531eng0927-77650927-776510.1016/j.colsurfb.2013.06.03123880088www.elsevier.com/locate/colsurfbinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:48:30Zoai:repositorium.sdum.uminho.pt:1822/25531Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:46:46.280651Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite
title Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite
spellingShingle Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite
Leitão, Alexandre F.
Bacterial cellulose
Biocompatibility
Biomaterials
Polyvinyl alcohol
Platelets
Hemocompatibility
Science & Technology
title_short Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite
title_full Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite
title_fullStr Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite
title_full_unstemmed Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite
title_sort Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite
author Leitão, Alexandre F.
author_facet Leitão, Alexandre F.
Gupta, Swati
Silva, João P.
Reviakine, I.
Gama, F. M.
author_role author
author2 Gupta, Swati
Silva, João P.
Reviakine, I.
Gama, F. M.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Leitão, Alexandre F.
Gupta, Swati
Silva, João P.
Reviakine, I.
Gama, F. M.
dc.subject.por.fl_str_mv Bacterial cellulose
Biocompatibility
Biomaterials
Polyvinyl alcohol
Platelets
Hemocompatibility
Science & Technology
topic Bacterial cellulose
Biocompatibility
Biomaterials
Polyvinyl alcohol
Platelets
Hemocompatibility
Science & Technology
description Bacterial cellulose (BC) has been suggested to be a suitable biomaterial for the development of cardiovascular grafts. The combination of BC with polyvinyl alcohol (PVA) results in nanocomposites with improved properties. Surprisingly, there are very few studies on the BC–blood interaction. This is the focus of this paper. We present the first thorough assessment of the hemocompatibility of the BC/PVA nanocomposite. Whole blood clotting time, plasma recalcification, Factor XII activation, platelet adhesion and activation, hemolytic index and complement activation are all determined. The platelet activation profiles on BC and BC/PVA surfaces are comprehensively characterized. BC and BC/PVA outperformed ePTFE – used as a point of comparison – thus evidencing their suitability for cardiovascular applications.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/25531
url http://hdl.handle.net/1822/25531
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0927-7765
0927-7765
10.1016/j.colsurfb.2013.06.031
23880088
www.elsevier.com/locate/colsurfb
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
Elsevier BV
publisher.none.fl_str_mv Elsevier
Elsevier BV
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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