Bacterial cellulose: a versatile biopolymer for wound dressing applications

Detalhes bibliográficos
Autor(a) principal: Portela, Raquel
Data de Publicação: 2019
Outros Autores: R. Leal, Catarina, Almeida, Pedro L., Sobral, Rita
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/10342
Resumo: Although several therapeutic approaches are available for wound and burn treatment and much progress has been made in this area, room for improvement still exists, driven by the urgent need of better strategies to accelerate wound healing and recovery, mostly for cases of severe burned patients. Bacterial cellulose (BC) is a biopolymer produced by bacteria with several advantages over vegetal cellulose, such as purity, high porosity, permeability to liquid and gases, elevated water uptake capacity and mechanical robustness. Besides its biocompatibility, BC can be modified in order to acquire antibacterial response and possible local drug delivery features. Due to its intrinsic versatility, BC is the perfect example of a biotechnological response to a clinical problem. In this review, we assess the BC main features and emphasis is given to a specific biomedical application: wound dressings. The production process and the physical-chemical properties that entitle this material to be used as wound dressing namely for burn healing are highlighted. An overview of the most common BC composites and their enhanced properties, in particular physical and biological, is provided, including the different production processes. A particular focus is given to the biochemistry and genetic manipulation of BC. A summary of the current marketed BC-based wound dressing products is presented, and finally, future perspectives for the usage of BC as wound dressing are foreseen.
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spelling Bacterial cellulose: a versatile biopolymer for wound dressing applicationsWoundBurn treatmentBacterial cellulose (BC)BiocompatibilityAlthough several therapeutic approaches are available for wound and burn treatment and much progress has been made in this area, room for improvement still exists, driven by the urgent need of better strategies to accelerate wound healing and recovery, mostly for cases of severe burned patients. Bacterial cellulose (BC) is a biopolymer produced by bacteria with several advantages over vegetal cellulose, such as purity, high porosity, permeability to liquid and gases, elevated water uptake capacity and mechanical robustness. Besides its biocompatibility, BC can be modified in order to acquire antibacterial response and possible local drug delivery features. Due to its intrinsic versatility, BC is the perfect example of a biotechnological response to a clinical problem. In this review, we assess the BC main features and emphasis is given to a specific biomedical application: wound dressings. The production process and the physical-chemical properties that entitle this material to be used as wound dressing namely for burn healing are highlighted. An overview of the most common BC composites and their enhanced properties, in particular physical and biological, is provided, including the different production processes. A particular focus is given to the biochemistry and genetic manipulation of BC. A summary of the current marketed BC-based wound dressing products is presented, and finally, future perspectives for the usage of BC as wound dressing are foreseen.WileyRCIPLPortela, RaquelR. Leal, CatarinaAlmeida, Pedro L.Sobral, Rita2019-07-19T13:52:19Z2019-072019-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/10342engPORTELA, Raquel; [et al] – Bacterial cellulose: a versatile biopolymer for wound dressing applications. Microbial Biotechnology. ISSN 1751-7915. Vol. 12, N.º 4 (2019), pp. 586-610 (SI)1751-791510.1111/1751-7915.13392metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:00:10Zoai:repositorio.ipl.pt:10400.21/10342Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:18:47.045875Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Bacterial cellulose: a versatile biopolymer for wound dressing applications
title Bacterial cellulose: a versatile biopolymer for wound dressing applications
spellingShingle Bacterial cellulose: a versatile biopolymer for wound dressing applications
Portela, Raquel
Wound
Burn treatment
Bacterial cellulose (BC)
Biocompatibility
title_short Bacterial cellulose: a versatile biopolymer for wound dressing applications
title_full Bacterial cellulose: a versatile biopolymer for wound dressing applications
title_fullStr Bacterial cellulose: a versatile biopolymer for wound dressing applications
title_full_unstemmed Bacterial cellulose: a versatile biopolymer for wound dressing applications
title_sort Bacterial cellulose: a versatile biopolymer for wound dressing applications
author Portela, Raquel
author_facet Portela, Raquel
R. Leal, Catarina
Almeida, Pedro L.
Sobral, Rita
author_role author
author2 R. Leal, Catarina
Almeida, Pedro L.
Sobral, Rita
author2_role author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Portela, Raquel
R. Leal, Catarina
Almeida, Pedro L.
Sobral, Rita
dc.subject.por.fl_str_mv Wound
Burn treatment
Bacterial cellulose (BC)
Biocompatibility
topic Wound
Burn treatment
Bacterial cellulose (BC)
Biocompatibility
description Although several therapeutic approaches are available for wound and burn treatment and much progress has been made in this area, room for improvement still exists, driven by the urgent need of better strategies to accelerate wound healing and recovery, mostly for cases of severe burned patients. Bacterial cellulose (BC) is a biopolymer produced by bacteria with several advantages over vegetal cellulose, such as purity, high porosity, permeability to liquid and gases, elevated water uptake capacity and mechanical robustness. Besides its biocompatibility, BC can be modified in order to acquire antibacterial response and possible local drug delivery features. Due to its intrinsic versatility, BC is the perfect example of a biotechnological response to a clinical problem. In this review, we assess the BC main features and emphasis is given to a specific biomedical application: wound dressings. The production process and the physical-chemical properties that entitle this material to be used as wound dressing namely for burn healing are highlighted. An overview of the most common BC composites and their enhanced properties, in particular physical and biological, is provided, including the different production processes. A particular focus is given to the biochemistry and genetic manipulation of BC. A summary of the current marketed BC-based wound dressing products is presented, and finally, future perspectives for the usage of BC as wound dressing are foreseen.
publishDate 2019
dc.date.none.fl_str_mv 2019-07-19T13:52:19Z
2019-07
2019-07-01T00:00:00Z
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format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/10342
url http://hdl.handle.net/10400.21/10342
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PORTELA, Raquel; [et al] – Bacterial cellulose: a versatile biopolymer for wound dressing applications. Microbial Biotechnology. ISSN 1751-7915. Vol. 12, N.º 4 (2019), pp. 586-610 (SI)
1751-7915
10.1111/1751-7915.13392
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dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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