Multifunctional materials for bone cancer treatment

Detalhes bibliográficos
Autor(a) principal: Marques, Catarina
Data de Publicação: 2014
Outros Autores: Ferreira, Jose M. F., Andronescu, Ecaterina, Ficai, Denisa, Sonmez, Maria, Ficai, Anton
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/19376
Resumo: The purpose of this review is to present the most recent findings in bone tissue engineering. Special attention is given to multifunctional materials based on collagen and collagen-hydroxyapatite composites used for skin and bone cancer treatments. The multi-functionality of these materials was obtained by adding to the base regenerative grafts proper components, such as ferrites (magnetite being the most important representative), cytostatics (cisplatin, carboplatin, vincristine, methotrexate, paclitaxel, doxorubicin), silver nanoparticles, antibiotics (anthracyclines, geldanamycin), and/or analgesics (ibuprofen, fentanyl). The suitability of complex systems for the intended applications was systematically analyzed. The developmental possibilities of multifunctional materials with regenerative and curative roles (antitumoral as well as pain management) in the field of skin and bone cancer treatment are discussed. It is worth mentioning that better materials are likely to be developed by combining conventional and unconventional experimental strategies.
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spelling Multifunctional materials for bone cancer treatmentDRUG-DELIVERY SYSTEMSCOLLAGEN/HYDROXYAPATITE COMPOSITE-MATERIALSSYNTHESIZED IN-VITROLOCAL-DELIVERYHYDROXYAPATITE/COLLAGEN COMPOSITEMAGNETITE NANOPARTICLESBIOMEDICAL APPLICATIONSSTAPHYLOCOCCUS-AUREUSPOROUS HYDROXYAPATITECOLLAGEN COMPOSITESThe purpose of this review is to present the most recent findings in bone tissue engineering. Special attention is given to multifunctional materials based on collagen and collagen-hydroxyapatite composites used for skin and bone cancer treatments. The multi-functionality of these materials was obtained by adding to the base regenerative grafts proper components, such as ferrites (magnetite being the most important representative), cytostatics (cisplatin, carboplatin, vincristine, methotrexate, paclitaxel, doxorubicin), silver nanoparticles, antibiotics (anthracyclines, geldanamycin), and/or analgesics (ibuprofen, fentanyl). The suitability of complex systems for the intended applications was systematically analyzed. The developmental possibilities of multifunctional materials with regenerative and curative roles (antitumoral as well as pain management) in the field of skin and bone cancer treatment are discussed. It is worth mentioning that better materials are likely to be developed by combining conventional and unconventional experimental strategies.DOVE MEDICAL PRESS LTD2017-12-07T19:10:39Z2014-01-01T00:00:00Z2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/19376eng1178-201310.2147/IJN.S55943Marques, CatarinaFerreira, Jose M. F.Andronescu, EcaterinaFicai, DenisaSonmez, MariaFicai, Antoninfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:37:37Zoai:ria.ua.pt:10773/19376Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:54:10.226538Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Multifunctional materials for bone cancer treatment
title Multifunctional materials for bone cancer treatment
spellingShingle Multifunctional materials for bone cancer treatment
Marques, Catarina
DRUG-DELIVERY SYSTEMS
COLLAGEN/HYDROXYAPATITE COMPOSITE-MATERIALS
SYNTHESIZED IN-VITRO
LOCAL-DELIVERY
HYDROXYAPATITE/COLLAGEN COMPOSITE
MAGNETITE NANOPARTICLES
BIOMEDICAL APPLICATIONS
STAPHYLOCOCCUS-AUREUS
POROUS HYDROXYAPATITE
COLLAGEN COMPOSITES
title_short Multifunctional materials for bone cancer treatment
title_full Multifunctional materials for bone cancer treatment
title_fullStr Multifunctional materials for bone cancer treatment
title_full_unstemmed Multifunctional materials for bone cancer treatment
title_sort Multifunctional materials for bone cancer treatment
author Marques, Catarina
author_facet Marques, Catarina
Ferreira, Jose M. F.
Andronescu, Ecaterina
Ficai, Denisa
Sonmez, Maria
Ficai, Anton
author_role author
author2 Ferreira, Jose M. F.
Andronescu, Ecaterina
Ficai, Denisa
Sonmez, Maria
Ficai, Anton
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Marques, Catarina
Ferreira, Jose M. F.
Andronescu, Ecaterina
Ficai, Denisa
Sonmez, Maria
Ficai, Anton
dc.subject.por.fl_str_mv DRUG-DELIVERY SYSTEMS
COLLAGEN/HYDROXYAPATITE COMPOSITE-MATERIALS
SYNTHESIZED IN-VITRO
LOCAL-DELIVERY
HYDROXYAPATITE/COLLAGEN COMPOSITE
MAGNETITE NANOPARTICLES
BIOMEDICAL APPLICATIONS
STAPHYLOCOCCUS-AUREUS
POROUS HYDROXYAPATITE
COLLAGEN COMPOSITES
topic DRUG-DELIVERY SYSTEMS
COLLAGEN/HYDROXYAPATITE COMPOSITE-MATERIALS
SYNTHESIZED IN-VITRO
LOCAL-DELIVERY
HYDROXYAPATITE/COLLAGEN COMPOSITE
MAGNETITE NANOPARTICLES
BIOMEDICAL APPLICATIONS
STAPHYLOCOCCUS-AUREUS
POROUS HYDROXYAPATITE
COLLAGEN COMPOSITES
description The purpose of this review is to present the most recent findings in bone tissue engineering. Special attention is given to multifunctional materials based on collagen and collagen-hydroxyapatite composites used for skin and bone cancer treatments. The multi-functionality of these materials was obtained by adding to the base regenerative grafts proper components, such as ferrites (magnetite being the most important representative), cytostatics (cisplatin, carboplatin, vincristine, methotrexate, paclitaxel, doxorubicin), silver nanoparticles, antibiotics (anthracyclines, geldanamycin), and/or analgesics (ibuprofen, fentanyl). The suitability of complex systems for the intended applications was systematically analyzed. The developmental possibilities of multifunctional materials with regenerative and curative roles (antitumoral as well as pain management) in the field of skin and bone cancer treatment are discussed. It is worth mentioning that better materials are likely to be developed by combining conventional and unconventional experimental strategies.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01T00:00:00Z
2014
2017-12-07T19:10:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/19376
url http://hdl.handle.net/10773/19376
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1178-2013
10.2147/IJN.S55943
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv DOVE MEDICAL PRESS LTD
publisher.none.fl_str_mv DOVE MEDICAL PRESS LTD
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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