Nanomedicine for the delivery of RNA in cancer
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/79903 |
Resumo: | The complexity, and the diversity of the different types of cancers allied to the tendency to form metastasis make treatment efficiency so tricky and often impossible due to the advanced stage of the disease in the diagnosis. In recent years, due to tremendous scientific breakthroughs, we have witnessed exponential growth in the elucidation of mechanisms that underlie carcinogenesis and metastasis. The development of more selective therapies made it possible to improve cancer treatment. Although interdisciplinary research leads to encouraging results, scientists still have a long exploration journey. RNA technology represents a promise as a therapeutic intervention for targeted gene silencing in cancer, and there are already some RNA-based formulations in clinical trials. However, the use of RNA as a therapeutic tool presents severe limitations, mainly related to its low stability and poor cellular uptake. Thus, the use of nanomedicine employing nanoparticles to encapsulate RNA may represent a suitable platform to address the major challenges hampering its therapeutic application. In this review, we have revisited the potential of RNA and RNA-associated therapies to fight cancer, also providing, as support, a general overview of nanoplatforms for RNA delivery. |
id |
RCAP_23ef9131f6f5b9fbc6ff3dae04542a1e |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/79903 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Nanomedicine for the delivery of RNA in cancerCancerDrug delivery systemsRNANanoparticlesScience & TechnologyThe complexity, and the diversity of the different types of cancers allied to the tendency to form metastasis make treatment efficiency so tricky and often impossible due to the advanced stage of the disease in the diagnosis. In recent years, due to tremendous scientific breakthroughs, we have witnessed exponential growth in the elucidation of mechanisms that underlie carcinogenesis and metastasis. The development of more selective therapies made it possible to improve cancer treatment. Although interdisciplinary research leads to encouraging results, scientists still have a long exploration journey. RNA technology represents a promise as a therapeutic intervention for targeted gene silencing in cancer, and there are already some RNA-based formulations in clinical trials. However, the use of RNA as a therapeutic tool presents severe limitations, mainly related to its low stability and poor cellular uptake. Thus, the use of nanomedicine employing nanoparticles to encapsulate RNA may represent a suitable platform to address the major challenges hampering its therapeutic application. In this review, we have revisited the potential of RNA and RNA-associated therapies to fight cancer, also providing, as support, a general overview of nanoplatforms for RNA delivery.This work received financial support from PT national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through project UIDB/50006/2020.Multidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoGhidini, MicheleSilva, Sandra G.Evangelista, JessicaVale, Maria Luísa C. doFarooqi, Ammad AhmadPinheiro, Marina2022-05-282022-05-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/79903engGhidini, M.; Silva, S.G.; Evangelista, J.; do Vale, M.L.C.; Farooqi, A.A.; Pinheiro, M. Nanomedicine for the Delivery of RNA in Cancer. Cancers 2022, 14, 2677. https://doi.org/10.3390/cancers141126772072-669410.3390/cancers141126772677https://www.mdpi.com/2072-6694/14/11/2677info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T07:28:53Zoai:repositorium.sdum.uminho.pt:1822/79903Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T07:28:53Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Nanomedicine for the delivery of RNA in cancer |
title |
Nanomedicine for the delivery of RNA in cancer |
spellingShingle |
Nanomedicine for the delivery of RNA in cancer Ghidini, Michele Cancer Drug delivery systems RNA Nanoparticles Science & Technology |
title_short |
Nanomedicine for the delivery of RNA in cancer |
title_full |
Nanomedicine for the delivery of RNA in cancer |
title_fullStr |
Nanomedicine for the delivery of RNA in cancer |
title_full_unstemmed |
Nanomedicine for the delivery of RNA in cancer |
title_sort |
Nanomedicine for the delivery of RNA in cancer |
author |
Ghidini, Michele |
author_facet |
Ghidini, Michele Silva, Sandra G. Evangelista, Jessica Vale, Maria Luísa C. do Farooqi, Ammad Ahmad Pinheiro, Marina |
author_role |
author |
author2 |
Silva, Sandra G. Evangelista, Jessica Vale, Maria Luísa C. do Farooqi, Ammad Ahmad Pinheiro, Marina |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Ghidini, Michele Silva, Sandra G. Evangelista, Jessica Vale, Maria Luísa C. do Farooqi, Ammad Ahmad Pinheiro, Marina |
dc.subject.por.fl_str_mv |
Cancer Drug delivery systems RNA Nanoparticles Science & Technology |
topic |
Cancer Drug delivery systems RNA Nanoparticles Science & Technology |
description |
The complexity, and the diversity of the different types of cancers allied to the tendency to form metastasis make treatment efficiency so tricky and often impossible due to the advanced stage of the disease in the diagnosis. In recent years, due to tremendous scientific breakthroughs, we have witnessed exponential growth in the elucidation of mechanisms that underlie carcinogenesis and metastasis. The development of more selective therapies made it possible to improve cancer treatment. Although interdisciplinary research leads to encouraging results, scientists still have a long exploration journey. RNA technology represents a promise as a therapeutic intervention for targeted gene silencing in cancer, and there are already some RNA-based formulations in clinical trials. However, the use of RNA as a therapeutic tool presents severe limitations, mainly related to its low stability and poor cellular uptake. Thus, the use of nanomedicine employing nanoparticles to encapsulate RNA may represent a suitable platform to address the major challenges hampering its therapeutic application. In this review, we have revisited the potential of RNA and RNA-associated therapies to fight cancer, also providing, as support, a general overview of nanoplatforms for RNA delivery. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-28 2022-05-28T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/79903 |
url |
https://hdl.handle.net/1822/79903 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ghidini, M.; Silva, S.G.; Evangelista, J.; do Vale, M.L.C.; Farooqi, A.A.; Pinheiro, M. Nanomedicine for the Delivery of RNA in Cancer. Cancers 2022, 14, 2677. https://doi.org/10.3390/cancers14112677 2072-6694 10.3390/cancers14112677 2677 https://www.mdpi.com/2072-6694/14/11/2677 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
_version_ |
1817545331984826368 |