Nanomedicine for the delivery of RNA in cancer

Detalhes bibliográficos
Autor(a) principal: Ghidini, Michele
Data de Publicação: 2022
Outros Autores: Silva, Sandra G., Evangelista, Jessica, Vale, Maria Luísa C. do, Farooqi, Ammad Ahmad, Pinheiro, Marina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/79903
Resumo: The complexity, and the diversity of the different types of cancers allied to the tendency to form metastasis make treatment efficiency so tricky and often impossible due to the advanced stage of the disease in the diagnosis. In recent years, due to tremendous scientific breakthroughs, we have witnessed exponential growth in the elucidation of mechanisms that underlie carcinogenesis and metastasis. The development of more selective therapies made it possible to improve cancer treatment. Although interdisciplinary research leads to encouraging results, scientists still have a long exploration journey. RNA technology represents a promise as a therapeutic intervention for targeted gene silencing in cancer, and there are already some RNA-based formulations in clinical trials. However, the use of RNA as a therapeutic tool presents severe limitations, mainly related to its low stability and poor cellular uptake. Thus, the use of nanomedicine employing nanoparticles to encapsulate RNA may represent a suitable platform to address the major challenges hampering its therapeutic application. In this review, we have revisited the potential of RNA and RNA-associated therapies to fight cancer, also providing, as support, a general overview of nanoplatforms for RNA delivery.
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spelling Nanomedicine for the delivery of RNA in cancerCancerDrug delivery systemsRNANanoparticlesScience & TechnologyThe complexity, and the diversity of the different types of cancers allied to the tendency to form metastasis make treatment efficiency so tricky and often impossible due to the advanced stage of the disease in the diagnosis. In recent years, due to tremendous scientific breakthroughs, we have witnessed exponential growth in the elucidation of mechanisms that underlie carcinogenesis and metastasis. The development of more selective therapies made it possible to improve cancer treatment. Although interdisciplinary research leads to encouraging results, scientists still have a long exploration journey. RNA technology represents a promise as a therapeutic intervention for targeted gene silencing in cancer, and there are already some RNA-based formulations in clinical trials. However, the use of RNA as a therapeutic tool presents severe limitations, mainly related to its low stability and poor cellular uptake. Thus, the use of nanomedicine employing nanoparticles to encapsulate RNA may represent a suitable platform to address the major challenges hampering its therapeutic application. In this review, we have revisited the potential of RNA and RNA-associated therapies to fight cancer, also providing, as support, a general overview of nanoplatforms for RNA delivery.This work received financial support from PT national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through project UIDB/50006/2020.Multidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoGhidini, MicheleSilva, Sandra G.Evangelista, JessicaVale, Maria Luísa C. doFarooqi, Ammad AhmadPinheiro, Marina2022-05-282022-05-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/79903engGhidini, M.; Silva, S.G.; Evangelista, J.; do Vale, M.L.C.; Farooqi, A.A.; Pinheiro, M. Nanomedicine for the Delivery of RNA in Cancer. Cancers 2022, 14, 2677. https://doi.org/10.3390/cancers141126772072-669410.3390/cancers141126772677https://www.mdpi.com/2072-6694/14/11/2677info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T07:28:53Zoai:repositorium.sdum.uminho.pt:1822/79903Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T07:28:53Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nanomedicine for the delivery of RNA in cancer
title Nanomedicine for the delivery of RNA in cancer
spellingShingle Nanomedicine for the delivery of RNA in cancer
Ghidini, Michele
Cancer
Drug delivery systems
RNA
Nanoparticles
Science & Technology
title_short Nanomedicine for the delivery of RNA in cancer
title_full Nanomedicine for the delivery of RNA in cancer
title_fullStr Nanomedicine for the delivery of RNA in cancer
title_full_unstemmed Nanomedicine for the delivery of RNA in cancer
title_sort Nanomedicine for the delivery of RNA in cancer
author Ghidini, Michele
author_facet Ghidini, Michele
Silva, Sandra G.
Evangelista, Jessica
Vale, Maria Luísa C. do
Farooqi, Ammad Ahmad
Pinheiro, Marina
author_role author
author2 Silva, Sandra G.
Evangelista, Jessica
Vale, Maria Luísa C. do
Farooqi, Ammad Ahmad
Pinheiro, Marina
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Ghidini, Michele
Silva, Sandra G.
Evangelista, Jessica
Vale, Maria Luísa C. do
Farooqi, Ammad Ahmad
Pinheiro, Marina
dc.subject.por.fl_str_mv Cancer
Drug delivery systems
RNA
Nanoparticles
Science & Technology
topic Cancer
Drug delivery systems
RNA
Nanoparticles
Science & Technology
description The complexity, and the diversity of the different types of cancers allied to the tendency to form metastasis make treatment efficiency so tricky and often impossible due to the advanced stage of the disease in the diagnosis. In recent years, due to tremendous scientific breakthroughs, we have witnessed exponential growth in the elucidation of mechanisms that underlie carcinogenesis and metastasis. The development of more selective therapies made it possible to improve cancer treatment. Although interdisciplinary research leads to encouraging results, scientists still have a long exploration journey. RNA technology represents a promise as a therapeutic intervention for targeted gene silencing in cancer, and there are already some RNA-based formulations in clinical trials. However, the use of RNA as a therapeutic tool presents severe limitations, mainly related to its low stability and poor cellular uptake. Thus, the use of nanomedicine employing nanoparticles to encapsulate RNA may represent a suitable platform to address the major challenges hampering its therapeutic application. In this review, we have revisited the potential of RNA and RNA-associated therapies to fight cancer, also providing, as support, a general overview of nanoplatforms for RNA delivery.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-28
2022-05-28T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/79903
url https://hdl.handle.net/1822/79903
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ghidini, M.; Silva, S.G.; Evangelista, J.; do Vale, M.L.C.; Farooqi, A.A.; Pinheiro, M. Nanomedicine for the Delivery of RNA in Cancer. Cancers 2022, 14, 2677. https://doi.org/10.3390/cancers14112677
2072-6694
10.3390/cancers14112677
2677
https://www.mdpi.com/2072-6694/14/11/2677
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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