Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.1038/s41598-019-50531-3 |
Resumo: | The authors thank to Shinozuka Tsuyoshi from Daiichi Sankyo, Japan, for the supply of arylpiperazine 5k (DS22420314). The research was funded by IPOLFG, EPE (FAI 2017) and by iNOVA4Health - UID/Multi/04462/a program fnancially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement and by Fundação para a Ciência e Tecnologia (personal fellowship: PD/BD/128337/2017). |
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Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapyGeneralSDG 3 - Good Health and Well-beingThe authors thank to Shinozuka Tsuyoshi from Daiichi Sankyo, Japan, for the supply of arylpiperazine 5k (DS22420314). The research was funded by IPOLFG, EPE (FAI 2017) and by iNOVA4Health - UID/Multi/04462/a program fnancially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement and by Fundação para a Ciência e Tecnologia (personal fellowship: PD/BD/128337/2017).The biochemical demands associated with tumor proliferation prompt neoplastic cells to augment the import of nutrients to sustain their survival and fuel cell growth, with a consequent metabolic remodeling. Fatty acids (FA) are crucial in this process, since they have a dual role as energetic coins and building blocks. Recently, our team has shown that FATP1 has a pivotal role in FA transfer between breast cancer cells (BCCs) and non-cancerous cells in the microenvironment. We aimed to investigate the role of FATP1 in BCCs and also to explore if FATP1 inhibition is a promising therapeutic strategy. In patients' data, we showed a higher expression of FATP1/SLC27A1 in TNBC, which correlated with a significant decreased overall survival (OS). In vitro, we verified that FA and estradiol stimulated FATP1/SLC27A1 expression in BCCs. Additionally, experiments with estradiol and PHTPP (ER-β antagonist) showed that estrogen receptor-β (ER-β) regulates FATP1/SLC27A1 expression, the uptake of FA and cell viability, in four BCC lines. Furthermore, the inhibition of FATP1 with arylpiperazine 5k (DS22420314) interfered with the uptake of FA and cell viability. Our study, unraveled FATP1 as a putative therapeutic target in breast cancer (BC).Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMendes, CindyLopes-Coelho, FilipaRamos, CristianoMartins, FilipaSantos, InêsRodrigues, ArmandaSilva, FernandaAndré, SaudadeSerpa, Jacinta2019-10-11T23:10:29Z2019-10-012019-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1application/pdfhttps://doi.org/10.1038/s41598-019-50531-3eng2045-2322PURE: 14980157http://www.scopus.com/inward/record.url?scp=85072847618&partnerID=8YFLogxKhttps://doi.org/10.1038/s41598-019-50531-3info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:37:33Zoai:run.unl.pt:10362/84041Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:36:25.679818Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy |
title |
Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy |
spellingShingle |
Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy Mendes, Cindy General SDG 3 - Good Health and Well-being |
title_short |
Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy |
title_full |
Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy |
title_fullStr |
Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy |
title_full_unstemmed |
Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy |
title_sort |
Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy |
author |
Mendes, Cindy |
author_facet |
Mendes, Cindy Lopes-Coelho, Filipa Ramos, Cristiano Martins, Filipa Santos, Inês Rodrigues, Armanda Silva, Fernanda André, Saudade Serpa, Jacinta |
author_role |
author |
author2 |
Lopes-Coelho, Filipa Ramos, Cristiano Martins, Filipa Santos, Inês Rodrigues, Armanda Silva, Fernanda André, Saudade Serpa, Jacinta |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Mendes, Cindy Lopes-Coelho, Filipa Ramos, Cristiano Martins, Filipa Santos, Inês Rodrigues, Armanda Silva, Fernanda André, Saudade Serpa, Jacinta |
dc.subject.por.fl_str_mv |
General SDG 3 - Good Health and Well-being |
topic |
General SDG 3 - Good Health and Well-being |
description |
The authors thank to Shinozuka Tsuyoshi from Daiichi Sankyo, Japan, for the supply of arylpiperazine 5k (DS22420314). The research was funded by IPOLFG, EPE (FAI 2017) and by iNOVA4Health - UID/Multi/04462/a program fnancially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement and by Fundação para a Ciência e Tecnologia (personal fellowship: PD/BD/128337/2017). |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-11T23:10:29Z 2019-10-01 2019-10-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1038/s41598-019-50531-3 |
url |
https://doi.org/10.1038/s41598-019-50531-3 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2045-2322 PURE: 14980157 http://www.scopus.com/inward/record.url?scp=85072847618&partnerID=8YFLogxK https://doi.org/10.1038/s41598-019-50531-3 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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1 application/pdf |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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