Surface Functionalization of PLGA Nanoparticles to Increase Transport across the BBB for Alzheimer’s Disease

Detalhes bibliográficos
Autor(a) principal: Del Amo, Laura
Data de Publicação: 2021
Outros Autores: Cano, Amanda, Ettcheto, Miren, Souto, Eliana B., Espina, Marta, Camins, Antoni, García, Maria Luísa, Sánchez-López, Elena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/103693
https://doi.org/10.3390/app11094305
Resumo: Alzheimer’s disease (AD) is a chronic neurodegenerative disorder that accounts for about 60% of all diagnosed cases of dementia worldwide. Although there are currently several drugs marketed for its treatment, none are capable of slowing down or stopping the progression of AD. The role of the blood-brain barrier (BBB) plays a key role in the design of a successful treatment for this neurodegenerative disease. Nanosized particles have been proposed as suitable drug delivery systems to overcome BBB with the purpose of increasing bioavailability of drugs in the brain. Biodegradable poly (lactic-co-glycolic acid) nanoparticles (PLGA-NPs) have been particularly regarded as promising drug delivery systems as they can be surface-tailored with functionalized molecules for site-specific targeting. In this review, a thorough discussion about the most recent functionalization strategies based on PLGA-NPs for AD and their mechanisms of action is provided, together with a description of AD pathogenesis and the role of the BBB in brain targeting.
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spelling Surface Functionalization of PLGA Nanoparticles to Increase Transport across the BBB for Alzheimer’s Diseasefunctionalized PLGA nanoparticlesbrain deliveryblood-brain barrierAlzheimer’s diseaseAlzheimer’s disease (AD) is a chronic neurodegenerative disorder that accounts for about 60% of all diagnosed cases of dementia worldwide. Although there are currently several drugs marketed for its treatment, none are capable of slowing down or stopping the progression of AD. The role of the blood-brain barrier (BBB) plays a key role in the design of a successful treatment for this neurodegenerative disease. Nanosized particles have been proposed as suitable drug delivery systems to overcome BBB with the purpose of increasing bioavailability of drugs in the brain. Biodegradable poly (lactic-co-glycolic acid) nanoparticles (PLGA-NPs) have been particularly regarded as promising drug delivery systems as they can be surface-tailored with functionalized molecules for site-specific targeting. In this review, a thorough discussion about the most recent functionalization strategies based on PLGA-NPs for AD and their mechanisms of action is provided, together with a description of AD pathogenesis and the role of the BBB in brain targeting.MDPI AG2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/103693http://hdl.handle.net/10316/103693https://doi.org/10.3390/app11094305eng2076-3417Del Amo, LauraCano, AmandaEttcheto, MirenSouto, Eliana B.Espina, MartaCamins, AntoniGarcía, Maria LuísaSánchez-López, Elenainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-22T21:44:41Zoai:estudogeral.uc.pt:10316/103693Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:20:29.033881Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Surface Functionalization of PLGA Nanoparticles to Increase Transport across the BBB for Alzheimer’s Disease
title Surface Functionalization of PLGA Nanoparticles to Increase Transport across the BBB for Alzheimer’s Disease
spellingShingle Surface Functionalization of PLGA Nanoparticles to Increase Transport across the BBB for Alzheimer’s Disease
Del Amo, Laura
functionalized PLGA nanoparticles
brain delivery
blood-brain barrier
Alzheimer’s disease
title_short Surface Functionalization of PLGA Nanoparticles to Increase Transport across the BBB for Alzheimer’s Disease
title_full Surface Functionalization of PLGA Nanoparticles to Increase Transport across the BBB for Alzheimer’s Disease
title_fullStr Surface Functionalization of PLGA Nanoparticles to Increase Transport across the BBB for Alzheimer’s Disease
title_full_unstemmed Surface Functionalization of PLGA Nanoparticles to Increase Transport across the BBB for Alzheimer’s Disease
title_sort Surface Functionalization of PLGA Nanoparticles to Increase Transport across the BBB for Alzheimer’s Disease
author Del Amo, Laura
author_facet Del Amo, Laura
Cano, Amanda
Ettcheto, Miren
Souto, Eliana B.
Espina, Marta
Camins, Antoni
García, Maria Luísa
Sánchez-López, Elena
author_role author
author2 Cano, Amanda
Ettcheto, Miren
Souto, Eliana B.
Espina, Marta
Camins, Antoni
García, Maria Luísa
Sánchez-López, Elena
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Del Amo, Laura
Cano, Amanda
Ettcheto, Miren
Souto, Eliana B.
Espina, Marta
Camins, Antoni
García, Maria Luísa
Sánchez-López, Elena
dc.subject.por.fl_str_mv functionalized PLGA nanoparticles
brain delivery
blood-brain barrier
Alzheimer’s disease
topic functionalized PLGA nanoparticles
brain delivery
blood-brain barrier
Alzheimer’s disease
description Alzheimer’s disease (AD) is a chronic neurodegenerative disorder that accounts for about 60% of all diagnosed cases of dementia worldwide. Although there are currently several drugs marketed for its treatment, none are capable of slowing down or stopping the progression of AD. The role of the blood-brain barrier (BBB) plays a key role in the design of a successful treatment for this neurodegenerative disease. Nanosized particles have been proposed as suitable drug delivery systems to overcome BBB with the purpose of increasing bioavailability of drugs in the brain. Biodegradable poly (lactic-co-glycolic acid) nanoparticles (PLGA-NPs) have been particularly regarded as promising drug delivery systems as they can be surface-tailored with functionalized molecules for site-specific targeting. In this review, a thorough discussion about the most recent functionalization strategies based on PLGA-NPs for AD and their mechanisms of action is provided, together with a description of AD pathogenesis and the role of the BBB in brain targeting.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/103693
http://hdl.handle.net/10316/103693
https://doi.org/10.3390/app11094305
url http://hdl.handle.net/10316/103693
https://doi.org/10.3390/app11094305
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2076-3417
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dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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