Surface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimers disease

Detalhes bibliográficos
Autor(a) principal: Del Amo, Laura
Data de Publicação: 2021
Outros Autores: Cano, Amanda, Ettcheto, Miren, Souto, Eliana B., Espina, Marta, Camins, Antoni, García, Maria Luísa, Sánchez-López, Elena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/72610
Resumo: Alzheimers disease (AD) is a chronic neurodegenerative disorder that accounts for about 60% of all diagnosed cases of dementia worldwide. Although there are currently several drugs marketed for its treatment, none are capable of slowing down or stopping the progression of AD. The role of the blood-brain barrier (BBB) plays a key role in the design of a successful treatment for this neurodegenerative disease. Nanosized particles have been proposed as suitable drug delivery systems to overcome BBB with the purpose of increasing bioavailability of drugs in the brain. Biodegradable poly (lactic-co-glycolic acid) nanoparticles (PLGA-NPs) have been particularly regarded as promising drug delivery systems as they can be surface-tailored with functionalized molecules for site-specific targeting. In this review, a thorough discussion about the most recent functionalization strategies based on PLGA-NPs for AD and their mechanisms of action is provided, together with a description of AD pathogenesis and the role of the BBB in brain targeting.
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spelling Surface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimers diseasefunctionalized PLGA nanoparticlesbrain deliveryblood-brain barrierAlzheimers diseaseAlzheimer’s diseaseAlzheimer&#8217Science & TechnologyAlzheimers disease (AD) is a chronic neurodegenerative disorder that accounts for about 60% of all diagnosed cases of dementia worldwide. Although there are currently several drugs marketed for its treatment, none are capable of slowing down or stopping the progression of AD. The role of the blood-brain barrier (BBB) plays a key role in the design of a successful treatment for this neurodegenerative disease. Nanosized particles have been proposed as suitable drug delivery systems to overcome BBB with the purpose of increasing bioavailability of drugs in the brain. Biodegradable poly (lactic-co-glycolic acid) nanoparticles (PLGA-NPs) have been particularly regarded as promising drug delivery systems as they can be surface-tailored with functionalized molecules for site-specific targeting. In this review, a thorough discussion about the most recent functionalization strategies based on PLGA-NPs for AD and their mechanisms of action is provided, together with a description of AD pathogenesis and the role of the BBB in brain targeting.A.C. [Amanda Cano] acknowledges the support of the Spanish Ministry of Science, Innovation and Universities under the grant Juan de la Cierva (FJC2018-036012-I). Authors acknowledge the support of the Spanish Ministry of Economy and Competitiveness under the project SAF2017-84283-R; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED, CB06/05/0024) and Portuguese Science and Technology Foundation (FCT) for the strategic fund (UIDB/04469/2020).info:eu-repo/semantics/publishedVersionMDPIUniversidade do MinhoDel Amo, LauraCano, AmandaEttcheto, MirenSouto, Eliana B.Espina, MartaCamins, AntoniGarcía, Maria LuísaSánchez-López, Elena2021-05-102021-05-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/72610engDel Amo, Laura; Cano, Amanda; Ettcheto, Miren; Souto, Eliana; Espina, Marta; Camins, Antoni; García, Maria Luísa; Sánchez-López, Elena, Surface Functionalization of PLGA Nanoparticles to Increase Transport across the BBB for Alzheimers Disease. Applied Sciences-Basel, 11(9), 4305, 20212076-341710.3390/app11094305https://www.mdpi.com/2076-3417/11/9/4305info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:18:07Zoai:repositorium.sdum.uminho.pt:1822/72610Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:10:51.556147Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Surface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimers disease
title Surface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimers disease
spellingShingle Surface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimers disease
Del Amo, Laura
functionalized PLGA nanoparticles
brain delivery
blood-brain barrier
Alzheimers disease
Alzheimer’
s disease
Alzheimer&#8217
Science & Technology
title_short Surface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimers disease
title_full Surface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimers disease
title_fullStr Surface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimers disease
title_full_unstemmed Surface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimers disease
title_sort Surface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimers disease
author Del Amo, Laura
author_facet Del Amo, Laura
Cano, Amanda
Ettcheto, Miren
Souto, Eliana B.
Espina, Marta
Camins, Antoni
García, Maria Luísa
Sánchez-López, Elena
author_role author
author2 Cano, Amanda
Ettcheto, Miren
Souto, Eliana B.
Espina, Marta
Camins, Antoni
García, Maria Luísa
Sánchez-López, Elena
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Del Amo, Laura
Cano, Amanda
Ettcheto, Miren
Souto, Eliana B.
Espina, Marta
Camins, Antoni
García, Maria Luísa
Sánchez-López, Elena
dc.subject.por.fl_str_mv functionalized PLGA nanoparticles
brain delivery
blood-brain barrier
Alzheimers disease
Alzheimer’
s disease
Alzheimer&#8217
Science & Technology
topic functionalized PLGA nanoparticles
brain delivery
blood-brain barrier
Alzheimers disease
Alzheimer’
s disease
Alzheimer&#8217
Science & Technology
description Alzheimers disease (AD) is a chronic neurodegenerative disorder that accounts for about 60% of all diagnosed cases of dementia worldwide. Although there are currently several drugs marketed for its treatment, none are capable of slowing down or stopping the progression of AD. The role of the blood-brain barrier (BBB) plays a key role in the design of a successful treatment for this neurodegenerative disease. Nanosized particles have been proposed as suitable drug delivery systems to overcome BBB with the purpose of increasing bioavailability of drugs in the brain. Biodegradable poly (lactic-co-glycolic acid) nanoparticles (PLGA-NPs) have been particularly regarded as promising drug delivery systems as they can be surface-tailored with functionalized molecules for site-specific targeting. In this review, a thorough discussion about the most recent functionalization strategies based on PLGA-NPs for AD and their mechanisms of action is provided, together with a description of AD pathogenesis and the role of the BBB in brain targeting.
publishDate 2021
dc.date.none.fl_str_mv 2021-05-10
2021-05-10T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/72610
url http://hdl.handle.net/1822/72610
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Del Amo, Laura; Cano, Amanda; Ettcheto, Miren; Souto, Eliana; Espina, Marta; Camins, Antoni; García, Maria Luísa; Sánchez-López, Elena, Surface Functionalization of PLGA Nanoparticles to Increase Transport across the BBB for Alzheimers Disease. Applied Sciences-Basel, 11(9), 4305, 2021
2076-3417
10.3390/app11094305
https://www.mdpi.com/2076-3417/11/9/4305
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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