Spotlight on latent tuberculosis infection screening for juvenile idiopathic arthritis in two countries, comparing high and low risk patients
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/141563 |
Resumo: | © 2022. The Author(s). |
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Spotlight on latent tuberculosis infection screening for juvenile idiopathic arthritis in two countries, comparing high and low risk patientsAdolescentAntirheumatic Agents/therapeutic useArthritis, Juvenile/complicationsCross-Sectional StudiesHumansInterferon-gamma Release Tests/methodsLatent Tuberculosis/diagnosisTuberculin Test/methodsSDG 3 - Good Health and Well-being© 2022. The Author(s).BACKGROUND: Rheumatic diseases are associated with an increase in overall risks of tuberculosis (TB). The aim of this study was to evaluate the frequency of TB and the frequency of latent TB infection (LTBI), in clinical practice, for juvenile idiopathic arthritis (JIA) patients from high and low risk of TB incidence endemic countries. METHODS: This is an international, multicenter, cross-sectional, observational study of data collection from Brazil and Registry of Portugal at REUMA.PT. The inclusion criteria were patients with Juvenile Idiopathic Arthritis (JIA) with age ≤ 18 years who underwent screening for Mycobacterium tuberculosis infection [tuberculin skin test (TST) and/or interferon gamma release assay (IGRA)]. Chest X-rays and history of exposure to TB were also assessed. RESULTS: 292 JIA patients were included; mean age 14.3 years, mean disease duration 7.5 years, 194 patients (66.4%) performed only TST, 14 (4.8%) only IGRA and 84 (28.8%) both. The frequency of LTBI (10.6%) and TB was similar between the two countries. The reasons for TB screening were different; in Brazil it was performed more often at JIA onset while in Portugal it was performed when starting Disease Modified Anti-Rheumatic Drugs (DMARD) treatment (p < 0.001). Isoniazid therapy was prescribed in 40 (13.7%) patients (31 with LTBI and 9 with epidemiologic risks and/or due to contact with sick people). Only three patients (1%) developed active TB. CONCLUSION: We found nearly 10% of patients with LTBI, a small percentage of patients with treatment due to epidemiologic risks and only 1% with active TB. Distinct reasons and screening methods for LTBI were observed between the two countries.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNPiotto, DanielaNicacio, AlineNeto, AgnaMourão, Ana FilipaOliveira-Ramos, FilipaCampanilho-Marques, RaquelGuedes, MargaridaCabral, MartaSantos, Maria JoséFonseca, João EuricoCanhão, HelenaAikawa, Nádia EmiOliveira, Sheila K FFerriani, Virginia P LPileggi, Gecilmara C SMagalhães, Claudia SSilva, Clovis ArturTerreri, Maria Teresa2022-07-07T22:27:59Z2022-06-102022-06-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/141563eng2523-3106PURE: 45211078https://doi.org/10.1186/s42358-022-00251-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:18:57Zoai:run.unl.pt:10362/141563Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:50:01.990248Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Spotlight on latent tuberculosis infection screening for juvenile idiopathic arthritis in two countries, comparing high and low risk patients |
| title |
Spotlight on latent tuberculosis infection screening for juvenile idiopathic arthritis in two countries, comparing high and low risk patients |
| spellingShingle |
Spotlight on latent tuberculosis infection screening for juvenile idiopathic arthritis in two countries, comparing high and low risk patients Piotto, Daniela Adolescent Antirheumatic Agents/therapeutic use Arthritis, Juvenile/complications Cross-Sectional Studies Humans Interferon-gamma Release Tests/methods Latent Tuberculosis/diagnosis Tuberculin Test/methods SDG 3 - Good Health and Well-being |
| title_short |
Spotlight on latent tuberculosis infection screening for juvenile idiopathic arthritis in two countries, comparing high and low risk patients |
| title_full |
Spotlight on latent tuberculosis infection screening for juvenile idiopathic arthritis in two countries, comparing high and low risk patients |
| title_fullStr |
Spotlight on latent tuberculosis infection screening for juvenile idiopathic arthritis in two countries, comparing high and low risk patients |
| title_full_unstemmed |
Spotlight on latent tuberculosis infection screening for juvenile idiopathic arthritis in two countries, comparing high and low risk patients |
| title_sort |
Spotlight on latent tuberculosis infection screening for juvenile idiopathic arthritis in two countries, comparing high and low risk patients |
| author |
Piotto, Daniela |
| author_facet |
Piotto, Daniela Nicacio, Aline Neto, Agna Mourão, Ana Filipa Oliveira-Ramos, Filipa Campanilho-Marques, Raquel Guedes, Margarida Cabral, Marta Santos, Maria José Fonseca, João Eurico Canhão, Helena Aikawa, Nádia Emi Oliveira, Sheila K F Ferriani, Virginia P L Pileggi, Gecilmara C S Magalhães, Claudia S Silva, Clovis Artur Terreri, Maria Teresa |
| author_role |
author |
| author2 |
Nicacio, Aline Neto, Agna Mourão, Ana Filipa Oliveira-Ramos, Filipa Campanilho-Marques, Raquel Guedes, Margarida Cabral, Marta Santos, Maria José Fonseca, João Eurico Canhão, Helena Aikawa, Nádia Emi Oliveira, Sheila K F Ferriani, Virginia P L Pileggi, Gecilmara C S Magalhães, Claudia S Silva, Clovis Artur Terreri, Maria Teresa |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Comprehensive Health Research Centre (CHRC) - pólo NMS RUN |
| dc.contributor.author.fl_str_mv |
Piotto, Daniela Nicacio, Aline Neto, Agna Mourão, Ana Filipa Oliveira-Ramos, Filipa Campanilho-Marques, Raquel Guedes, Margarida Cabral, Marta Santos, Maria José Fonseca, João Eurico Canhão, Helena Aikawa, Nádia Emi Oliveira, Sheila K F Ferriani, Virginia P L Pileggi, Gecilmara C S Magalhães, Claudia S Silva, Clovis Artur Terreri, Maria Teresa |
| dc.subject.por.fl_str_mv |
Adolescent Antirheumatic Agents/therapeutic use Arthritis, Juvenile/complications Cross-Sectional Studies Humans Interferon-gamma Release Tests/methods Latent Tuberculosis/diagnosis Tuberculin Test/methods SDG 3 - Good Health and Well-being |
| topic |
Adolescent Antirheumatic Agents/therapeutic use Arthritis, Juvenile/complications Cross-Sectional Studies Humans Interferon-gamma Release Tests/methods Latent Tuberculosis/diagnosis Tuberculin Test/methods SDG 3 - Good Health and Well-being |
| description |
© 2022. The Author(s). |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-07-07T22:27:59Z 2022-06-10 2022-06-10T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/141563 |
| url |
http://hdl.handle.net/10362/141563 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2523-3106 PURE: 45211078 https://doi.org/10.1186/s42358-022-00251-6 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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