From amino acid sequence to bioactivity: the biomedical potential of antitumor peptides
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/41900 |
Resumo: | Chemoprevention is the use of natural and/or synthetic substances to block, reverse, or retard the process of carcinogenesis. In this field, the use of antitumor peptides is of interest as, (i) these molecules are small in size, (ii) they show good cell diffusion and permeability, (iii) they affect one or more specific molecular pathways involved in carcinogenesis, and (iv) they are not usually genotoxic. We have checked the Web of Science Database (23/11/2015) in order to collect papers reporting on bioactive peptide (1691 registers), which was further filtered searching terms such as antiproliferative, antitumoral, or apoptosis among others. Works reporting the amino acid sequence of an antiproliferative peptide were kept (60 registers), and this was complemented with the peptides included in CancerPPD, an extensive resource for antiproliferative peptides and proteins. Peptides were grouped according to one of the following mechanism of action: inhibition of cell migration, inhibition of tumor angiogenesis, antioxidative mechanisms, inhibition of gene transcription/cell proliferation, induction of apoptosis, disorganization of tubulin structure, cytotoxicity, or unknown mechanisms. The main mechanisms of action of those antiproliferative peptides with known amino acid sequences are presented and finally, their potential clinical usefulness and future challenges on their application is discussed. |
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From amino acid sequence to bioactivity: the biomedical potential of antitumor peptidesBioactive peptideAntitumoralAntiproliferativeCancerTumorScience & TechnologyChemoprevention is the use of natural and/or synthetic substances to block, reverse, or retard the process of carcinogenesis. In this field, the use of antitumor peptides is of interest as, (i) these molecules are small in size, (ii) they show good cell diffusion and permeability, (iii) they affect one or more specific molecular pathways involved in carcinogenesis, and (iv) they are not usually genotoxic. We have checked the Web of Science Database (23/11/2015) in order to collect papers reporting on bioactive peptide (1691 registers), which was further filtered searching terms such as antiproliferative, antitumoral, or apoptosis among others. Works reporting the amino acid sequence of an antiproliferative peptide were kept (60 registers), and this was complemented with the peptides included in CancerPPD, an extensive resource for antiproliferative peptides and proteins. Peptides were grouped according to one of the following mechanism of action: inhibition of cell migration, inhibition of tumor angiogenesis, antioxidative mechanisms, inhibition of gene transcription/cell proliferation, induction of apoptosis, disorganization of tubulin structure, cytotoxicity, or unknown mechanisms. The main mechanisms of action of those antiproliferative peptides with known amino acid sequences are presented and finally, their potential clinical usefulness and future challenges on their application is discussed.Grant sponsor: Spanish Programa Estatal de Investigacion, Desarrollo e Inovacion Orientada a los Retos de la Sociedad; Grant number: AGL2013-44039-R; Grant sponsor: Plan galego de investigacion, innovacion e crecemento 2011-2015; Grant number: EM2014/046; Grant sponsor: University of Vigo; Grant number: 14VI05; Grant sponsor: Spanish Ministerio de Economia y Competividad (Ramon y Cajal postdoctoral contract); Grant number: RYC-2012-10052 (to Borja Sanchez).Wiley-BlackwellUniversidade do MinhoBlanco-Míguez, AitorGutiérrez-Jácome, AlbertoPérez-Pérez, MartínPérez-Rodríguez, GaelCatalán-García, SandraFdez-Riverola, FlorentinoLourenço, AnáliaSánchez, Borja2016-062016-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/41900engBlanco-Míguez, Aitor; Gutiérrez-Jácome, Alberto; Pérez-Pérez, Martín; Pérez-Rodríguez, Gael; Catalán-García, Sandra; Fdez-Riverola, Florentino; Lourenço, Anália; Sánchez, Borja, From amino acid sequence to bioactivity: The biomedical potential of antitumor peptides. Protein Science, 25(6), 1084-1095, 20160961-83681469-896X10.1002/pro.292727010507http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1469-896Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:12:49Zoai:repositorium.sdum.uminho.pt:1822/41900Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:04:49.792839Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
From amino acid sequence to bioactivity: the biomedical potential of antitumor peptides |
title |
From amino acid sequence to bioactivity: the biomedical potential of antitumor peptides |
spellingShingle |
From amino acid sequence to bioactivity: the biomedical potential of antitumor peptides Blanco-Míguez, Aitor Bioactive peptide Antitumoral Antiproliferative Cancer Tumor Science & Technology |
title_short |
From amino acid sequence to bioactivity: the biomedical potential of antitumor peptides |
title_full |
From amino acid sequence to bioactivity: the biomedical potential of antitumor peptides |
title_fullStr |
From amino acid sequence to bioactivity: the biomedical potential of antitumor peptides |
title_full_unstemmed |
From amino acid sequence to bioactivity: the biomedical potential of antitumor peptides |
title_sort |
From amino acid sequence to bioactivity: the biomedical potential of antitumor peptides |
author |
Blanco-Míguez, Aitor |
author_facet |
Blanco-Míguez, Aitor Gutiérrez-Jácome, Alberto Pérez-Pérez, Martín Pérez-Rodríguez, Gael Catalán-García, Sandra Fdez-Riverola, Florentino Lourenço, Anália Sánchez, Borja |
author_role |
author |
author2 |
Gutiérrez-Jácome, Alberto Pérez-Pérez, Martín Pérez-Rodríguez, Gael Catalán-García, Sandra Fdez-Riverola, Florentino Lourenço, Anália Sánchez, Borja |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Blanco-Míguez, Aitor Gutiérrez-Jácome, Alberto Pérez-Pérez, Martín Pérez-Rodríguez, Gael Catalán-García, Sandra Fdez-Riverola, Florentino Lourenço, Anália Sánchez, Borja |
dc.subject.por.fl_str_mv |
Bioactive peptide Antitumoral Antiproliferative Cancer Tumor Science & Technology |
topic |
Bioactive peptide Antitumoral Antiproliferative Cancer Tumor Science & Technology |
description |
Chemoprevention is the use of natural and/or synthetic substances to block, reverse, or retard the process of carcinogenesis. In this field, the use of antitumor peptides is of interest as, (i) these molecules are small in size, (ii) they show good cell diffusion and permeability, (iii) they affect one or more specific molecular pathways involved in carcinogenesis, and (iv) they are not usually genotoxic. We have checked the Web of Science Database (23/11/2015) in order to collect papers reporting on bioactive peptide (1691 registers), which was further filtered searching terms such as antiproliferative, antitumoral, or apoptosis among others. Works reporting the amino acid sequence of an antiproliferative peptide were kept (60 registers), and this was complemented with the peptides included in CancerPPD, an extensive resource for antiproliferative peptides and proteins. Peptides were grouped according to one of the following mechanism of action: inhibition of cell migration, inhibition of tumor angiogenesis, antioxidative mechanisms, inhibition of gene transcription/cell proliferation, induction of apoptosis, disorganization of tubulin structure, cytotoxicity, or unknown mechanisms. The main mechanisms of action of those antiproliferative peptides with known amino acid sequences are presented and finally, their potential clinical usefulness and future challenges on their application is discussed. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06 2016-06-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/41900 |
url |
http://hdl.handle.net/1822/41900 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Blanco-Míguez, Aitor; Gutiérrez-Jácome, Alberto; Pérez-Pérez, Martín; Pérez-Rodríguez, Gael; Catalán-García, Sandra; Fdez-Riverola, Florentino; Lourenço, Anália; Sánchez, Borja, From amino acid sequence to bioactivity: The biomedical potential of antitumor peptides. Protein Science, 25(6), 1084-1095, 2016 0961-8368 1469-896X 10.1002/pro.2927 27010507 http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1469-896X |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132458246995968 |