Antioxidant and antitumor potential of wild and IMTA-cultivated Osmundea pinnatifida

Detalhes bibliográficos
Autor(a) principal: Silva, J. Paulo
Data de Publicação: 2019
Outros Autores: Alves, Celso, Pinteus, Susete, Silva, Joana, Valado, Ana, Pedrosa, Rui, Pereira, Leonel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/5070
Resumo: This work had the support of Fundação para a Ciência e Tecnologia (FCT), through the strategic project (No. UID/MAR/04292/2013) granted to MARE. This work had also the support from the European Union through EASME Blue Labs project AMALIA—Algae-to-MArket Lab IdeAs (No.EASME/EMFF/2016/1.2.1.4/03/SI2.750419). Received funding from European Structural & Investment Funds through the COMPETE Programme and from National Funds through FCT—Fundação para a Ciência e a Tecnologia under the Programme (No.SAICTPAC/0019/2015).
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spelling Antioxidant and antitumor potential of wild and IMTA-cultivated Osmundea pinnatifidaEdible seaweedBioactive compoundsPolyphenolsCytotoxic activityAntiproliferative activityThis work had the support of Fundação para a Ciência e Tecnologia (FCT), through the strategic project (No. UID/MAR/04292/2013) granted to MARE. This work had also the support from the European Union through EASME Blue Labs project AMALIA—Algae-to-MArket Lab IdeAs (No.EASME/EMFF/2016/1.2.1.4/03/SI2.750419). Received funding from European Structural & Investment Funds through the COMPETE Programme and from National Funds through FCT—Fundação para a Ciência e a Tecnologia under the Programme (No.SAICTPAC/0019/2015).Osmundea pinnatifida is a red edible seaweed known as pepper dulse. O. pinnatifida was cultivated in the farm of ALGAplus (Ílhavo, Portugal). This farm is integrated with a seabream and seabass commercial aquaculture and uses the nutrient-enriched water resultant from the fish production as its cultivation medium in the integrated multi-trophic aquaculture (IMTA) manner. Wild and IMTA-cultivated samples of O. pinnatifida were screened for antioxidant and antitumor activities. The antioxidant capacity of solvent extracts from wild and IMTA cultivated samples was assessed in two methods (2,2-diphenyl- 1-picrylhydrazyl (DPPH) and oxygen radical absorbance capacity (ORAC)), and their total phenolic contents (TPC) were estimated. Antitumor activity was evaluated in three different tumor cell lines (HepG- 2, MCF-7, and SH-SY5Y) through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Among the solvents used for extraction, dichloromethane was the most effective to extract phenolic compounds and presented higher ORAC. A significant correlation was found between TPC and ORAC, which was also sustained by the principal components analysis (PCA). Dichloromethane extracts induced a cytostatic effect on MCF-7 cells and showed weak cytotoxicity to SH-SY5Y cells and weak impact on cell proliferation. Overall, there were no statistically signifi cant diff erences in the biological activities shown by the wild and IMTA-cultivated samples. Hence, O. pinnatifida can be obtained in an economical and environmentally sustainable way through IMTA, maintaining bioactive properties in a high potential for further nutraceutical purposes.Springer VerlagIC-OnlineSilva, J. PauloAlves, CelsoPinteus, SuseteSilva, JoanaValado, AnaPedrosa, RuiPereira, Leonel2020-08-12T10:51:06Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/5070engSilva, P.J. & Alves, C. & Pinteus, S. & Silva, J. & Valado, A. & Pedrosa, R. & Pereira, L. (2019). Antioxidant and antitumor potential of wild and IMTA-cultivated Osmundea pinnatifida. Journal of Oceanology and Limnology. 37. 825-835. 10.1007/s00343-019-8110-4.1993-500510.1007/s00343-019-8110-4metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:50:34Zoai:iconline.ipleiria.pt:10400.8/5070Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:48:45.450967Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Antioxidant and antitumor potential of wild and IMTA-cultivated Osmundea pinnatifida
title Antioxidant and antitumor potential of wild and IMTA-cultivated Osmundea pinnatifida
spellingShingle Antioxidant and antitumor potential of wild and IMTA-cultivated Osmundea pinnatifida
Silva, J. Paulo
Edible seaweed
Bioactive compounds
Polyphenols
Cytotoxic activity
Antiproliferative activity
title_short Antioxidant and antitumor potential of wild and IMTA-cultivated Osmundea pinnatifida
title_full Antioxidant and antitumor potential of wild and IMTA-cultivated Osmundea pinnatifida
title_fullStr Antioxidant and antitumor potential of wild and IMTA-cultivated Osmundea pinnatifida
title_full_unstemmed Antioxidant and antitumor potential of wild and IMTA-cultivated Osmundea pinnatifida
title_sort Antioxidant and antitumor potential of wild and IMTA-cultivated Osmundea pinnatifida
author Silva, J. Paulo
author_facet Silva, J. Paulo
Alves, Celso
Pinteus, Susete
Silva, Joana
Valado, Ana
Pedrosa, Rui
Pereira, Leonel
author_role author
author2 Alves, Celso
Pinteus, Susete
Silva, Joana
Valado, Ana
Pedrosa, Rui
Pereira, Leonel
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Silva, J. Paulo
Alves, Celso
Pinteus, Susete
Silva, Joana
Valado, Ana
Pedrosa, Rui
Pereira, Leonel
dc.subject.por.fl_str_mv Edible seaweed
Bioactive compounds
Polyphenols
Cytotoxic activity
Antiproliferative activity
topic Edible seaweed
Bioactive compounds
Polyphenols
Cytotoxic activity
Antiproliferative activity
description This work had the support of Fundação para a Ciência e Tecnologia (FCT), through the strategic project (No. UID/MAR/04292/2013) granted to MARE. This work had also the support from the European Union through EASME Blue Labs project AMALIA—Algae-to-MArket Lab IdeAs (No.EASME/EMFF/2016/1.2.1.4/03/SI2.750419). Received funding from European Structural & Investment Funds through the COMPETE Programme and from National Funds through FCT—Fundação para a Ciência e a Tecnologia under the Programme (No.SAICTPAC/0019/2015).
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2020-08-12T10:51:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/5070
url http://hdl.handle.net/10400.8/5070
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Silva, P.J. & Alves, C. & Pinteus, S. & Silva, J. & Valado, A. & Pedrosa, R. & Pereira, L. (2019). Antioxidant and antitumor potential of wild and IMTA-cultivated Osmundea pinnatifida. Journal of Oceanology and Limnology. 37. 825-835. 10.1007/s00343-019-8110-4.
1993-5005
10.1007/s00343-019-8110-4
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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