Increased monohexosylceramide levels in the serum of established rheumatoid arthritis patients

Detalhes bibliográficos
Autor(a) principal: Miltenberger-Miltenyi, Gabriel
Data de Publicação: 2020
Outros Autores: Machado, Ana Rita, Saville, Jennifer, Conceição, Vasco A., Calado, Ângelo, Lopes, Inês, Fuller, Maria, Fonseca, João Eurico
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/45020
Resumo: © The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com
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spelling Increased monohexosylceramide levels in the serum of established rheumatoid arthritis patientsBiomarkerRheumatoid arthritisSerum sphingolipid levels© The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.comObjectives: To identify serum sphingolipids that could act as candidate biomarkers in RA. Methods: We performed lipidomic analyses in the serum of 82 participants: 19 established RA patients, 18 untreated early RA patients, 13 untreated early arthritis patients not fulfilling the classification criteria for RA, 12 established SpA patients and 20 controls. We compared the lipid levels from the different patient groups with the control group through multiple-regression analyses controlling for age at diagnosis, gender and medication (cDMARDs and corticoids). Results: Established RA patients had significantly increased levels of sphingosine, monohexosylceramide and ceramide compared with controls, when controlling for age and gender. Monohexosylceramide levels remained significantly increased when additionally controlling for medication. On the contrary, SpA patients had significantly decreased levels of ceramide, in both analyses. Conclusion: We observed a detectable increase in the levels of certain sphingolipids in the serum of established RA patients when compared with controls, in line with previous observations in the synovial fluid. Such findings provide further evidence that sphingolipids may play a key role in the pathophysiology of RA.This study was supported by a grant from thePortuguese Society of Rheumatology and by UID/BIM/50005/2019, a project funded by Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência,Tecnologia e Ensino Superior (MCTES) through Fundosdo Orçamento de Estado.Oxford University PressRepositório da Universidade de LisboaMiltenberger-Miltenyi, GabrielMachado, Ana RitaSaville, JenniferConceição, Vasco A.Calado, ÂngeloLopes, InêsFuller, MariaFonseca, João Eurico2020-11-25T12:54:37Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/45020engRheumatology, Volume 59, Issue 8, August 2020, Pages 2085–20891462-032410.1093/rheumatology/kez5451462-0332info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:46:27Zoai:repositorio.ul.pt:10451/45020Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:57:29.833002Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Increased monohexosylceramide levels in the serum of established rheumatoid arthritis patients
title Increased monohexosylceramide levels in the serum of established rheumatoid arthritis patients
spellingShingle Increased monohexosylceramide levels in the serum of established rheumatoid arthritis patients
Miltenberger-Miltenyi, Gabriel
Biomarker
Rheumatoid arthritis
Serum sphingolipid levels
title_short Increased monohexosylceramide levels in the serum of established rheumatoid arthritis patients
title_full Increased monohexosylceramide levels in the serum of established rheumatoid arthritis patients
title_fullStr Increased monohexosylceramide levels in the serum of established rheumatoid arthritis patients
title_full_unstemmed Increased monohexosylceramide levels in the serum of established rheumatoid arthritis patients
title_sort Increased monohexosylceramide levels in the serum of established rheumatoid arthritis patients
author Miltenberger-Miltenyi, Gabriel
author_facet Miltenberger-Miltenyi, Gabriel
Machado, Ana Rita
Saville, Jennifer
Conceição, Vasco A.
Calado, Ângelo
Lopes, Inês
Fuller, Maria
Fonseca, João Eurico
author_role author
author2 Machado, Ana Rita
Saville, Jennifer
Conceição, Vasco A.
Calado, Ângelo
Lopes, Inês
Fuller, Maria
Fonseca, João Eurico
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Miltenberger-Miltenyi, Gabriel
Machado, Ana Rita
Saville, Jennifer
Conceição, Vasco A.
Calado, Ângelo
Lopes, Inês
Fuller, Maria
Fonseca, João Eurico
dc.subject.por.fl_str_mv Biomarker
Rheumatoid arthritis
Serum sphingolipid levels
topic Biomarker
Rheumatoid arthritis
Serum sphingolipid levels
description © The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com
publishDate 2020
dc.date.none.fl_str_mv 2020-11-25T12:54:37Z
2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/45020
url http://hdl.handle.net/10451/45020
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rheumatology, Volume 59, Issue 8, August 2020, Pages 2085–2089
1462-0324
10.1093/rheumatology/kez545
1462-0332
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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