How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept

Detalhes bibliográficos
Autor(a) principal: Marques, Cíntia
Data de Publicação: 2020
Outros Autores: Som, Claudia, Schmutz, Mélanie, Borges, Olga, Borchard, Gerrit
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/106099
https://doi.org/10.3389/fbioe.2020.00165
Resumo: Efficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization of preparation and characterization methods and their accurate reporting is needed. Focusing on the example of chitosan, a biopolymer derived from chitin and frequently used in drug and vaccine delivery vector preparation, this review discusses the challenges still to be met and overcome prior to a successful implementation of the SbD approach to the preparation of chitosan-based protein drug delivery systems.
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spelling How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Conceptsafe by designpolymeric drug carrierschitosaninsulinprotein drug deliveryEfficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization of preparation and characterization methods and their accurate reporting is needed. Focusing on the example of chitosan, a biopolymer derived from chitin and frequently used in drug and vaccine delivery vector preparation, this review discusses the challenges still to be met and overcome prior to a successful implementation of the SbD approach to the preparation of chitosan-based protein drug delivery systems.Frontiers Media S.A.2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106099http://hdl.handle.net/10316/106099https://doi.org/10.3389/fbioe.2020.00165eng2296-4185Marques, CíntiaSom, ClaudiaSchmutz, MélanieBorges, OlgaBorchard, Gerritinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-20T21:33:48Zoai:estudogeral.uc.pt:10316/106099Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:33.954486Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept
title How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept
spellingShingle How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept
Marques, Cíntia
safe by design
polymeric drug carriers
chitosan
insulin
protein drug delivery
title_short How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept
title_full How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept
title_fullStr How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept
title_full_unstemmed How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept
title_sort How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept
author Marques, Cíntia
author_facet Marques, Cíntia
Som, Claudia
Schmutz, Mélanie
Borges, Olga
Borchard, Gerrit
author_role author
author2 Som, Claudia
Schmutz, Mélanie
Borges, Olga
Borchard, Gerrit
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Marques, Cíntia
Som, Claudia
Schmutz, Mélanie
Borges, Olga
Borchard, Gerrit
dc.subject.por.fl_str_mv safe by design
polymeric drug carriers
chitosan
insulin
protein drug delivery
topic safe by design
polymeric drug carriers
chitosan
insulin
protein drug delivery
description Efficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization of preparation and characterization methods and their accurate reporting is needed. Focusing on the example of chitosan, a biopolymer derived from chitin and frequently used in drug and vaccine delivery vector preparation, this review discusses the challenges still to be met and overcome prior to a successful implementation of the SbD approach to the preparation of chitosan-based protein drug delivery systems.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/106099
http://hdl.handle.net/10316/106099
https://doi.org/10.3389/fbioe.2020.00165
url http://hdl.handle.net/10316/106099
https://doi.org/10.3389/fbioe.2020.00165
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2296-4185
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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