Phosphorous containing chitosan beads for controlled oral drug delivery
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/20154 |
Resumo: | Phosphorous containing chitosan (PCTS) was synthesized by a graft copolymerization technique in order to be used as controlled drug delivery devices. To test this potential, PCTS beads were prepared by using tripolyphosphate, at pH 4.0 and characterized by scanning electron microscopy. The in vitro drug release behavior in various pH solutions was studied using indomethacin (IM) as a model drug at two different concentrations (0.3 and 0.6% w/w). The release percent of IM from PCTS beads was found to be increased with the increasing of pH in the buffer solution. The release rate of IM at pH 7.4 was higher than that at pH 1.4, due to the ionization of phosphorous groups and the high solubility of IM in the alkaline medium. These results indicated that PCTS beads have the potential to be used as controlled drug delivery systems through oral administration by avoiding the drug release in the highly acidic gastric fluid region of the stomach. |
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Phosphorous containing chitosan beads for controlled oral drug deliveryModified chitosanChitosan beadsIndomethacinDrug deliverypH sensitive drug deliveryoral drug deliveryScience & TechnologyPhosphorous containing chitosan (PCTS) was synthesized by a graft copolymerization technique in order to be used as controlled drug delivery devices. To test this potential, PCTS beads were prepared by using tripolyphosphate, at pH 4.0 and characterized by scanning electron microscopy. The in vitro drug release behavior in various pH solutions was studied using indomethacin (IM) as a model drug at two different concentrations (0.3 and 0.6% w/w). The release percent of IM from PCTS beads was found to be increased with the increasing of pH in the buffer solution. The release rate of IM at pH 7.4 was higher than that at pH 1.4, due to the ionization of phosphorous groups and the high solubility of IM in the alkaline medium. These results indicated that PCTS beads have the potential to be used as controlled drug delivery systems through oral administration by avoiding the drug release in the highly acidic gastric fluid region of the stomach.SAGE Publications LtdUniversidade do MinhoJayakumar, R.Reis, R. L.Mano, J. F.20062006-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/20154eng0883-911510.1177/0883911506066929info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:21:44Zoai:repositorium.sdum.uminho.pt:1822/20154Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:15:04.752715Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Phosphorous containing chitosan beads for controlled oral drug delivery |
title |
Phosphorous containing chitosan beads for controlled oral drug delivery |
spellingShingle |
Phosphorous containing chitosan beads for controlled oral drug delivery Jayakumar, R. Modified chitosan Chitosan beads Indomethacin Drug delivery pH sensitive drug delivery oral drug delivery Science & Technology |
title_short |
Phosphorous containing chitosan beads for controlled oral drug delivery |
title_full |
Phosphorous containing chitosan beads for controlled oral drug delivery |
title_fullStr |
Phosphorous containing chitosan beads for controlled oral drug delivery |
title_full_unstemmed |
Phosphorous containing chitosan beads for controlled oral drug delivery |
title_sort |
Phosphorous containing chitosan beads for controlled oral drug delivery |
author |
Jayakumar, R. |
author_facet |
Jayakumar, R. Reis, R. L. Mano, J. F. |
author_role |
author |
author2 |
Reis, R. L. Mano, J. F. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Jayakumar, R. Reis, R. L. Mano, J. F. |
dc.subject.por.fl_str_mv |
Modified chitosan Chitosan beads Indomethacin Drug delivery pH sensitive drug delivery oral drug delivery Science & Technology |
topic |
Modified chitosan Chitosan beads Indomethacin Drug delivery pH sensitive drug delivery oral drug delivery Science & Technology |
description |
Phosphorous containing chitosan (PCTS) was synthesized by a graft copolymerization technique in order to be used as controlled drug delivery devices. To test this potential, PCTS beads were prepared by using tripolyphosphate, at pH 4.0 and characterized by scanning electron microscopy. The in vitro drug release behavior in various pH solutions was studied using indomethacin (IM) as a model drug at two different concentrations (0.3 and 0.6% w/w). The release percent of IM from PCTS beads was found to be increased with the increasing of pH in the buffer solution. The release rate of IM at pH 7.4 was higher than that at pH 1.4, due to the ionization of phosphorous groups and the high solubility of IM in the alkaline medium. These results indicated that PCTS beads have the potential to be used as controlled drug delivery systems through oral administration by avoiding the drug release in the highly acidic gastric fluid region of the stomach. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006 2006-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/20154 |
url |
http://hdl.handle.net/1822/20154 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0883-9115 10.1177/0883911506066929 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
SAGE Publications Ltd |
publisher.none.fl_str_mv |
SAGE Publications Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132595265470464 |