Phosphorous containing chitosan beads for controlled oral drug delivery

Detalhes bibliográficos
Autor(a) principal: Jayakumar, R.
Data de Publicação: 2006
Outros Autores: Reis, R. L., Mano, J. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/20154
Resumo: Phosphorous containing chitosan (PCTS) was synthesized by a graft copolymerization technique in order to be used as controlled drug delivery devices. To test this potential, PCTS beads were prepared by using tripolyphosphate, at pH 4.0 and characterized by scanning electron microscopy. The in vitro drug release behavior in various pH solutions was studied using indomethacin (IM) as a model drug at two different concentrations (0.3 and 0.6% w/w). The release percent of IM from PCTS beads was found to be increased with the increasing of pH in the buffer solution. The release rate of IM at pH 7.4 was higher than that at pH 1.4, due to the ionization of phosphorous groups and the high solubility of IM in the alkaline medium. These results indicated that PCTS beads have the potential to be used as controlled drug delivery systems through oral administration by avoiding the drug release in the highly acidic gastric fluid region of the stomach.
id RCAP_9cb32c39d2fe2efbee4144caaeda41e1
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/20154
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Phosphorous containing chitosan beads for controlled oral drug deliveryModified chitosanChitosan beadsIndomethacinDrug deliverypH sensitive drug deliveryoral drug deliveryScience & TechnologyPhosphorous containing chitosan (PCTS) was synthesized by a graft copolymerization technique in order to be used as controlled drug delivery devices. To test this potential, PCTS beads were prepared by using tripolyphosphate, at pH 4.0 and characterized by scanning electron microscopy. The in vitro drug release behavior in various pH solutions was studied using indomethacin (IM) as a model drug at two different concentrations (0.3 and 0.6% w/w). The release percent of IM from PCTS beads was found to be increased with the increasing of pH in the buffer solution. The release rate of IM at pH 7.4 was higher than that at pH 1.4, due to the ionization of phosphorous groups and the high solubility of IM in the alkaline medium. These results indicated that PCTS beads have the potential to be used as controlled drug delivery systems through oral administration by avoiding the drug release in the highly acidic gastric fluid region of the stomach.SAGE Publications LtdUniversidade do MinhoJayakumar, R.Reis, R. L.Mano, J. F.20062006-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/20154eng0883-911510.1177/0883911506066929info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:21:44Zoai:repositorium.sdum.uminho.pt:1822/20154Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:15:04.752715Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Phosphorous containing chitosan beads for controlled oral drug delivery
title Phosphorous containing chitosan beads for controlled oral drug delivery
spellingShingle Phosphorous containing chitosan beads for controlled oral drug delivery
Jayakumar, R.
Modified chitosan
Chitosan beads
Indomethacin
Drug delivery
pH sensitive drug delivery
oral drug delivery
Science & Technology
title_short Phosphorous containing chitosan beads for controlled oral drug delivery
title_full Phosphorous containing chitosan beads for controlled oral drug delivery
title_fullStr Phosphorous containing chitosan beads for controlled oral drug delivery
title_full_unstemmed Phosphorous containing chitosan beads for controlled oral drug delivery
title_sort Phosphorous containing chitosan beads for controlled oral drug delivery
author Jayakumar, R.
author_facet Jayakumar, R.
Reis, R. L.
Mano, J. F.
author_role author
author2 Reis, R. L.
Mano, J. F.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Jayakumar, R.
Reis, R. L.
Mano, J. F.
dc.subject.por.fl_str_mv Modified chitosan
Chitosan beads
Indomethacin
Drug delivery
pH sensitive drug delivery
oral drug delivery
Science & Technology
topic Modified chitosan
Chitosan beads
Indomethacin
Drug delivery
pH sensitive drug delivery
oral drug delivery
Science & Technology
description Phosphorous containing chitosan (PCTS) was synthesized by a graft copolymerization technique in order to be used as controlled drug delivery devices. To test this potential, PCTS beads were prepared by using tripolyphosphate, at pH 4.0 and characterized by scanning electron microscopy. The in vitro drug release behavior in various pH solutions was studied using indomethacin (IM) as a model drug at two different concentrations (0.3 and 0.6% w/w). The release percent of IM from PCTS beads was found to be increased with the increasing of pH in the buffer solution. The release rate of IM at pH 7.4 was higher than that at pH 1.4, due to the ionization of phosphorous groups and the high solubility of IM in the alkaline medium. These results indicated that PCTS beads have the potential to be used as controlled drug delivery systems through oral administration by avoiding the drug release in the highly acidic gastric fluid region of the stomach.
publishDate 2006
dc.date.none.fl_str_mv 2006
2006-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/20154
url http://hdl.handle.net/1822/20154
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0883-9115
10.1177/0883911506066929
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SAGE Publications Ltd
publisher.none.fl_str_mv SAGE Publications Ltd
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132595265470464