Changes in expression of the CLOCK gene in obstructive sleep apnea syndrome patients are not reverted by continuous positive airway pressure treatment

Detalhes bibliográficos
Autor(a) principal: Moreira, Susana
Data de Publicação: 2017
Outros Autores: Rodrigues, Raquel, Barros, André, Pejanovic, Nada, Neves-Costa, Ana, Pedroso, Dora, Pereira, Cláudia, Fernandes, Dina, Rodrigues, João Valença, Bárbara, Cristina, Moita, Luis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/51481
Resumo: Copyright: © 2017 Moreira, Rodrigues, Barros, Pejanovic, Neves-Costa, Pedroso, Pereira, Fernandes, Rodrigues, Barbara and Moita. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Changes in expression of the CLOCK gene in obstructive sleep apnea syndrome patients are not reverted by continuous positive airway pressure treatmentCircadian RhythmsMetabolic SyndromeClock genesContinuous positive airway pressureObstructive sleep apnea syndromeSlow wave sleepCopyright: © 2017 Moreira, Rodrigues, Barros, Pejanovic, Neves-Costa, Pedroso, Pereira, Fernandes, Rodrigues, Barbara and Moita. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Purpose: Metabolic syndrome and cardiovascular disease are strongly associated with obstructive sleep apnea syndrome (OSAS), which causes substantial changes to normal circadian physiological functions, including metabolic pathways. Because core clock genes are known to be modulated by sleep/vigilance cycles, we asked whether the expression level of mRNA coding for clock genes is altered in non-treated OSAS patients and if it can be corrected by standard continuous positive airway pressure (CPAP) treatment. Methods: Peripheral blood was collected from male patients diagnosed with severe OSAS (apnea-hypopnea index ≥ 30/h) before and after treatment initiation. qPCR was used to measure mRNA levels of genes associated with the central circadian pacemaker including CLOCK, BMAL1, Cry1, Cry2, and three Period genes (Per 1, 2, 3) in peripheral blood mononuclear cells (PBMCs). Results: We found statistically significant differences for CLOCK (p-value = 0.022) expression in PBMCs of OSAS patients which were not reverted by treatment with CPAP. We have also found a substantial decrease in the slow wave sleep (SWS) content in OSAS patients (p-value < 0.001) that, contrary to REM sleep, was not corrected by CPAP (p-value = 0.875). Conclusion: CPAP treatment does not correct substantial changes in expression of core clock genes in OSAS patients. Because CPAP treatment is also unable to normalize the SWS in these patients, it is likely that additional therapeutic interventions that increase SWS content and complement the benefits of CPAP are required to more effectively reduce the known increased cardiovascular risk associated with OSAS patients.LM directs the Innate Immunity and Inflammation Laboratory at IGC, is an FCT Investigator and receives financial support from Fundação para a Ciência e Tecnologia (FCT) and the European Research Council (ERC-2014-CoG 647888-iPROTECTION). The sponsors had no role in the design or conduct of this research.FrontiersRepositório da Universidade de LisboaMoreira, SusanaRodrigues, RaquelBarros, AndréPejanovic, NadaNeves-Costa, AnaPedroso, DoraPereira, CláudiaFernandes, DinaRodrigues, João ValençaBárbara, CristinaMoita, Luis2022-02-23T16:04:03Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/51481engFront Med (Lausanne). 2017 Nov 6;4:18710.3389/fmed.2017.001872296-858Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:56:10Zoai:repositorio.ul.pt:10451/51481Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:45.102862Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Changes in expression of the CLOCK gene in obstructive sleep apnea syndrome patients are not reverted by continuous positive airway pressure treatment
title Changes in expression of the CLOCK gene in obstructive sleep apnea syndrome patients are not reverted by continuous positive airway pressure treatment
spellingShingle Changes in expression of the CLOCK gene in obstructive sleep apnea syndrome patients are not reverted by continuous positive airway pressure treatment
Moreira, Susana
Circadian Rhythms
Metabolic Syndrome
Clock genes
Continuous positive airway pressure
Obstructive sleep apnea syndrome
Slow wave sleep
title_short Changes in expression of the CLOCK gene in obstructive sleep apnea syndrome patients are not reverted by continuous positive airway pressure treatment
title_full Changes in expression of the CLOCK gene in obstructive sleep apnea syndrome patients are not reverted by continuous positive airway pressure treatment
title_fullStr Changes in expression of the CLOCK gene in obstructive sleep apnea syndrome patients are not reverted by continuous positive airway pressure treatment
title_full_unstemmed Changes in expression of the CLOCK gene in obstructive sleep apnea syndrome patients are not reverted by continuous positive airway pressure treatment
title_sort Changes in expression of the CLOCK gene in obstructive sleep apnea syndrome patients are not reverted by continuous positive airway pressure treatment
author Moreira, Susana
author_facet Moreira, Susana
Rodrigues, Raquel
Barros, André
Pejanovic, Nada
Neves-Costa, Ana
Pedroso, Dora
Pereira, Cláudia
Fernandes, Dina
Rodrigues, João Valença
Bárbara, Cristina
Moita, Luis
author_role author
author2 Rodrigues, Raquel
Barros, André
Pejanovic, Nada
Neves-Costa, Ana
Pedroso, Dora
Pereira, Cláudia
Fernandes, Dina
Rodrigues, João Valença
Bárbara, Cristina
Moita, Luis
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Moreira, Susana
Rodrigues, Raquel
Barros, André
Pejanovic, Nada
Neves-Costa, Ana
Pedroso, Dora
Pereira, Cláudia
Fernandes, Dina
Rodrigues, João Valença
Bárbara, Cristina
Moita, Luis
dc.subject.por.fl_str_mv Circadian Rhythms
Metabolic Syndrome
Clock genes
Continuous positive airway pressure
Obstructive sleep apnea syndrome
Slow wave sleep
topic Circadian Rhythms
Metabolic Syndrome
Clock genes
Continuous positive airway pressure
Obstructive sleep apnea syndrome
Slow wave sleep
description Copyright: © 2017 Moreira, Rodrigues, Barros, Pejanovic, Neves-Costa, Pedroso, Pereira, Fernandes, Rodrigues, Barbara and Moita. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2022-02-23T16:04:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/51481
url http://hdl.handle.net/10451/51481
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Med (Lausanne). 2017 Nov 6;4:187
10.3389/fmed.2017.00187
2296-858X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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