Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment

Detalhes bibliográficos
Autor(a) principal: Moreira, Susana
Data de Publicação: 2017
Outros Autores: Rodrigues, Raquel, Barros, André B., Pejanovic, Nadja, Neves-Costa, Ana, Pedroso, Dora, Pereira, Cláudia, Fernandes, Dina, Rodrigues, João Valença, Barbara, Cristina, Moita, Luís Ferreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/814
Resumo: This deposit is composed by the main article plus the supplementary materials of the publication.
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spelling Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatmentobstructive sleep apnea syndromeclock genescontinuous positive airway pressureslow wave sleepMetabolic SyndromeCircadian RhythmsThis deposit is composed by the main article plus the supplementary materials of the publication.Metabolic syndrome and cardiovascular disease are strongly associated with obstructive sleep apnea syndrome (OSAS), which causes substantial changes to normal circadian physiological functions, including metabolic pathways. Because core clock genes are known to be modulated by sleep/vigilance cycles, we asked whether the expression level of mRNA coding for clock genes is altered in non-treated OSAS patients and if it can be corrected by standard continuous positive airway pressure (CPAP) treatment.Fundação para a Ciência e Tecnologia; European Research Council grant: (ERC-2014-CoG 647888-iPROTECTION).Frontiers MediaARCAMoreira, SusanaRodrigues, RaquelBarros, André B.Pejanovic, NadjaNeves-Costa, AnaPedroso, DoraPereira, CláudiaFernandes, DinaRodrigues, João ValençaBarbara, CristinaMoita, Luís Ferreira2017-12-05T16:44:05Z2017-11-062017-11-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.7/814engMoreira S, Rodrigues R, Barros AB, Pejanovic N, Neves-Costa A, Pedroso D, Pereira C, Fernandes D, Rodrigues JV, Barbara C and Moita LF (2017) Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment. Front. Med. 4:187. doi: 10.3389/fmed.2017.0018710.3389/fmed.2017.00187info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:13Zoai:arca.igc.gulbenkian.pt:10400.7/814Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:02.287451Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment
title Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment
spellingShingle Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment
Moreira, Susana
obstructive sleep apnea syndrome
clock genes
continuous positive airway pressure
slow wave sleep
Metabolic Syndrome
Circadian Rhythms
title_short Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment
title_full Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment
title_fullStr Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment
title_full_unstemmed Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment
title_sort Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment
author Moreira, Susana
author_facet Moreira, Susana
Rodrigues, Raquel
Barros, André B.
Pejanovic, Nadja
Neves-Costa, Ana
Pedroso, Dora
Pereira, Cláudia
Fernandes, Dina
Rodrigues, João Valença
Barbara, Cristina
Moita, Luís Ferreira
author_role author
author2 Rodrigues, Raquel
Barros, André B.
Pejanovic, Nadja
Neves-Costa, Ana
Pedroso, Dora
Pereira, Cláudia
Fernandes, Dina
Rodrigues, João Valença
Barbara, Cristina
Moita, Luís Ferreira
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Moreira, Susana
Rodrigues, Raquel
Barros, André B.
Pejanovic, Nadja
Neves-Costa, Ana
Pedroso, Dora
Pereira, Cláudia
Fernandes, Dina
Rodrigues, João Valença
Barbara, Cristina
Moita, Luís Ferreira
dc.subject.por.fl_str_mv obstructive sleep apnea syndrome
clock genes
continuous positive airway pressure
slow wave sleep
Metabolic Syndrome
Circadian Rhythms
topic obstructive sleep apnea syndrome
clock genes
continuous positive airway pressure
slow wave sleep
Metabolic Syndrome
Circadian Rhythms
description This deposit is composed by the main article plus the supplementary materials of the publication.
publishDate 2017
dc.date.none.fl_str_mv 2017-12-05T16:44:05Z
2017-11-06
2017-11-06T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/814
url http://hdl.handle.net/10400.7/814
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Moreira S, Rodrigues R, Barros AB, Pejanovic N, Neves-Costa A, Pedroso D, Pereira C, Fernandes D, Rodrigues JV, Barbara C and Moita LF (2017) Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment. Front. Med. 4:187. doi: 10.3389/fmed.2017.00187
10.3389/fmed.2017.00187
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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