Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response

Detalhes bibliográficos
Autor(a) principal: Direito, Inês
Data de Publicação: 2019
Outros Autores: Fardilha, Margarida, Helguero, Luisa A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/29389
Resumo: Resistant breast and prostate cancers remain a major clinical problem, new therapeutic approaches and better predictors of therapeutic response are clearly needed. Because of the involvement of the unfolded protein response (UPR) in cell proliferation and apoptosis evasion, an increasing number of publications support the hypothesis that impairments in this network trigger and/or exacerbate cancer. Moreover, UPR activation could contribute to the development of drug resistance phenotypes in both breast and prostate cancers. Therefore, targeting this pathway has recently emerged as a promising strategy in anticancer therapy. This review addresses the contribution of UPR to breast and prostate tissues homeostasis and its significance to cancer endocrine response with focus on the current progress on UPR research related to cancer biology, detection, prognosis and treatment.
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spelling Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine responseResistant breast and prostate cancers remain a major clinical problem, new therapeutic approaches and better predictors of therapeutic response are clearly needed. Because of the involvement of the unfolded protein response (UPR) in cell proliferation and apoptosis evasion, an increasing number of publications support the hypothesis that impairments in this network trigger and/or exacerbate cancer. Moreover, UPR activation could contribute to the development of drug resistance phenotypes in both breast and prostate cancers. Therefore, targeting this pathway has recently emerged as a promising strategy in anticancer therapy. This review addresses the contribution of UPR to breast and prostate tissues homeostasis and its significance to cancer endocrine response with focus on the current progress on UPR research related to cancer biology, detection, prognosis and treatment.Oxford University Press (OUP)2020-10-08T17:46:40Z2019-02-01T00:00:00Z2019-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/29389eng0143-333410.1093/carcin/bgy182Direito, InêsFardilha, MargaridaHelguero, Luisa Ainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:56:31Zoai:ria.ua.pt:10773/29389Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:01:36.571669Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response
title Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response
spellingShingle Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response
Direito, Inês
title_short Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response
title_full Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response
title_fullStr Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response
title_full_unstemmed Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response
title_sort Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response
author Direito, Inês
author_facet Direito, Inês
Fardilha, Margarida
Helguero, Luisa A
author_role author
author2 Fardilha, Margarida
Helguero, Luisa A
author2_role author
author
dc.contributor.author.fl_str_mv Direito, Inês
Fardilha, Margarida
Helguero, Luisa A
description Resistant breast and prostate cancers remain a major clinical problem, new therapeutic approaches and better predictors of therapeutic response are clearly needed. Because of the involvement of the unfolded protein response (UPR) in cell proliferation and apoptosis evasion, an increasing number of publications support the hypothesis that impairments in this network trigger and/or exacerbate cancer. Moreover, UPR activation could contribute to the development of drug resistance phenotypes in both breast and prostate cancers. Therefore, targeting this pathway has recently emerged as a promising strategy in anticancer therapy. This review addresses the contribution of UPR to breast and prostate tissues homeostasis and its significance to cancer endocrine response with focus on the current progress on UPR research related to cancer biology, detection, prognosis and treatment.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-01T00:00:00Z
2019-02
2020-10-08T17:46:40Z
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10.1093/carcin/bgy182
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dc.publisher.none.fl_str_mv Oxford University Press (OUP)
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