Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/29389 |
Resumo: | Resistant breast and prostate cancers remain a major clinical problem, new therapeutic approaches and better predictors of therapeutic response are clearly needed. Because of the involvement of the unfolded protein response (UPR) in cell proliferation and apoptosis evasion, an increasing number of publications support the hypothesis that impairments in this network trigger and/or exacerbate cancer. Moreover, UPR activation could contribute to the development of drug resistance phenotypes in both breast and prostate cancers. Therefore, targeting this pathway has recently emerged as a promising strategy in anticancer therapy. This review addresses the contribution of UPR to breast and prostate tissues homeostasis and its significance to cancer endocrine response with focus on the current progress on UPR research related to cancer biology, detection, prognosis and treatment. |
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Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine responseResistant breast and prostate cancers remain a major clinical problem, new therapeutic approaches and better predictors of therapeutic response are clearly needed. Because of the involvement of the unfolded protein response (UPR) in cell proliferation and apoptosis evasion, an increasing number of publications support the hypothesis that impairments in this network trigger and/or exacerbate cancer. Moreover, UPR activation could contribute to the development of drug resistance phenotypes in both breast and prostate cancers. Therefore, targeting this pathway has recently emerged as a promising strategy in anticancer therapy. This review addresses the contribution of UPR to breast and prostate tissues homeostasis and its significance to cancer endocrine response with focus on the current progress on UPR research related to cancer biology, detection, prognosis and treatment.Oxford University Press (OUP)2020-10-08T17:46:40Z2019-02-01T00:00:00Z2019-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/29389eng0143-333410.1093/carcin/bgy182Direito, InêsFardilha, MargaridaHelguero, Luisa Ainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:56:31Zoai:ria.ua.pt:10773/29389Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:01:36.571669Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response |
title |
Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response |
spellingShingle |
Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response Direito, Inês |
title_short |
Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response |
title_full |
Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response |
title_fullStr |
Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response |
title_full_unstemmed |
Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response |
title_sort |
Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response |
author |
Direito, Inês |
author_facet |
Direito, Inês Fardilha, Margarida Helguero, Luisa A |
author_role |
author |
author2 |
Fardilha, Margarida Helguero, Luisa A |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Direito, Inês Fardilha, Margarida Helguero, Luisa A |
description |
Resistant breast and prostate cancers remain a major clinical problem, new therapeutic approaches and better predictors of therapeutic response are clearly needed. Because of the involvement of the unfolded protein response (UPR) in cell proliferation and apoptosis evasion, an increasing number of publications support the hypothesis that impairments in this network trigger and/or exacerbate cancer. Moreover, UPR activation could contribute to the development of drug resistance phenotypes in both breast and prostate cancers. Therefore, targeting this pathway has recently emerged as a promising strategy in anticancer therapy. This review addresses the contribution of UPR to breast and prostate tissues homeostasis and its significance to cancer endocrine response with focus on the current progress on UPR research related to cancer biology, detection, prognosis and treatment. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-02-01T00:00:00Z 2019-02 2020-10-08T17:46:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/29389 |
url |
http://hdl.handle.net/10773/29389 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0143-3334 10.1093/carcin/bgy182 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press (OUP) |
publisher.none.fl_str_mv |
Oxford University Press (OUP) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137671816151040 |