Exposure determinants of cadmium in European mothers and their children
| Autor(a) principal: | |
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| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/15333 |
Resumo: | © 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CCBY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
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Exposure determinants of cadmium in European mothers and their childrenBiomonitoringMother–child pairsUrinary cadmiumExposure predictorsDEMOCOPHES© 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CCBY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).The metal cadmium (Cd) is a widespread environmental pollutant with documented adverse effects on the kidneys and bones from long-term environmental exposure, but with insufficiently elucidated public health consequences such as risk of cardiovascular disease, hormone-related cancer in adults and developmental effects in children. This study is the first pan-European human biomonitoring project that succeeded in performing harmonized measurements of Cd in urine in a comparable way in mother–child couples from 16 European countries. The aim of the study was to evaluate the overall Cd exposure and significant determinants of Cd exposure. A study population of 1632 women (24–52 years of age), and 1689 children (5–12 years of age), from 32 rural and urban areas, was examined within a core period of 6 months in 2011–2012. Women were stratified as smokers and non-smokers. As expected, smoking mothers had higher geometric mean (gm) urinary cadmium (UCd; 0.24 µg/g crea; n=360) than non-smoking mothers (gm 0.18 µg/g crea; n=1272; p<0.0001), and children had lower UCd (gm 0.065 µg/g crea; n=1689) than their mothers at the country level. Non-smoking women exposed to environmental tobacco smoke (ETS) at home had 14% (95% CI 1–28%) higher UCd than those who were not exposed to ETS at home (p=0.04). No influence of ETS at home or other places on UCd levels was detected in children. Smoking women with primary education as the highest educational level of the household had 48% (95% CI 18–86%) higher UCd than those with tertiary education (p=0.0008). The same observation was seen in non-smoking women and in children; however they were not statistically significant. In children, living in a rural area was associated with 7% (95% CI 1–13%) higher UCd (p=0.03) compared to living in an urban area. Children, 9–12 years had 7% (95% CI 1–13%) higher UCd (p=0.04) than children 5–8 years. About 1% of the mothers, and 0.06% of the children, exceeded the tolerable weekly intake (TWI) appointed by EFSA, corresponding to 1.0 µg Cd/g crea in urine. Poland had the highest UCd in comparison between the 16 countries, while Denmark had the lowest. Whether the differences between countries are related to differences in the degree of environmental Cd contamination or to differences in lifestyle, socioeconomic status or dietary patterns is not clear.Financially supported by the 7th EU framework programe(DGResearch – No. 244237-COPHES),LIFE+ 2009(DG Environment – LIFE09ENV/BE000410-DEMOCOPHES),with addi- tional co-funding from DEMOCOPHES partners.ElsevierRepositório da Universidade de LisboaBerglund, MarikaLarsson, KristinGrandér, MargarethaCasteleyn, LudwineKolossa-Gehring, MarikeSchwedler, GerdaCastaño, ArgeliaEsteban, MartaAngerer, JürgenKoch, Holger M.Schindler, Birgit K.Schoeters, GreetSmolders, RoelExley, KarenSepai, OvnairBlumen, LuiesHorvat, MilenaKnudsen, Lisbeth E.Mørck, Thit A.Joas, AnkeJoas, ReinhardBiot, PierreAerts, DominiqueDe Cremer, KoenVan Overmeire, IlseKatsonouri, AndromachiHadjipanayis, AdamosCerna, MilenaKrskova, AndreaNielsen, Jeanette K. S.FangelJensen, JanneRudnai, PeterKozepesy, SzilviaGriffin, ChrisNesbitt, IanGutleb, Arno C.Fischer, Marc E.Ligocka, DanutaJakubowski, MarekReis, M. FátimaNamorado, SóniaLupsa, Ioana-RodicaGurzau, Anca E.Halzlova, KatarinaJajcaj, MichalMazej, DarjaTratnik, Janja SnojLopez, AnaCañas, AnaLehmann, AndreaCrettaz, PierreDen Hond, EllyGovarts, Eva2014-11-24T16:56:07Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/15333engEnviron. Res. (2014), http://dx.doi.org/10.1016/j.envres.2014.09.042i0013-9351http://dx.doi.org/10.1016/j.envres.2014.09.042info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T17:20:56Zoai:repositorio.ul.pt:10451/15333Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T17:20:56Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Exposure determinants of cadmium in European mothers and their children |
| title |
Exposure determinants of cadmium in European mothers and their children |
| spellingShingle |
Exposure determinants of cadmium in European mothers and their children Berglund, Marika Biomonitoring Mother–child pairs Urinary cadmium Exposure predictors DEMOCOPHES |
| title_short |
Exposure determinants of cadmium in European mothers and their children |
| title_full |
Exposure determinants of cadmium in European mothers and their children |
| title_fullStr |
Exposure determinants of cadmium in European mothers and their children |
| title_full_unstemmed |
Exposure determinants of cadmium in European mothers and their children |
| title_sort |
Exposure determinants of cadmium in European mothers and their children |
| author |
Berglund, Marika |
| author_facet |
Berglund, Marika Larsson, Kristin Grandér, Margaretha Casteleyn, Ludwine Kolossa-Gehring, Marike Schwedler, Gerda Castaño, Argelia Esteban, Marta Angerer, Jürgen Koch, Holger M. Schindler, Birgit K. Schoeters, Greet Smolders, Roel Exley, Karen Sepai, Ovnair Blumen, Luies Horvat, Milena Knudsen, Lisbeth E. Mørck, Thit A. Joas, Anke Joas, Reinhard Biot, Pierre Aerts, Dominique De Cremer, Koen Van Overmeire, Ilse Katsonouri, Andromachi Hadjipanayis, Adamos Cerna, Milena Krskova, Andrea Nielsen, Jeanette K. S. FangelJensen, Janne Rudnai, Peter Kozepesy, Szilvia Griffin, Chris Nesbitt, Ian Gutleb, Arno C. Fischer, Marc E. Ligocka, Danuta Jakubowski, Marek Reis, M. Fátima Namorado, Sónia Lupsa, Ioana-Rodica Gurzau, Anca E. Halzlova, Katarina Jajcaj, Michal Mazej, Darja Tratnik, Janja Snoj Lopez, Ana Cañas, Ana Lehmann, Andrea Crettaz, Pierre Den Hond, Elly Govarts, Eva |
| author_role |
author |
| author2 |
Larsson, Kristin Grandér, Margaretha Casteleyn, Ludwine Kolossa-Gehring, Marike Schwedler, Gerda Castaño, Argelia Esteban, Marta Angerer, Jürgen Koch, Holger M. Schindler, Birgit K. Schoeters, Greet Smolders, Roel Exley, Karen Sepai, Ovnair Blumen, Luies Horvat, Milena Knudsen, Lisbeth E. Mørck, Thit A. Joas, Anke Joas, Reinhard Biot, Pierre Aerts, Dominique De Cremer, Koen Van Overmeire, Ilse Katsonouri, Andromachi Hadjipanayis, Adamos Cerna, Milena Krskova, Andrea Nielsen, Jeanette K. S. FangelJensen, Janne Rudnai, Peter Kozepesy, Szilvia Griffin, Chris Nesbitt, Ian Gutleb, Arno C. Fischer, Marc E. Ligocka, Danuta Jakubowski, Marek Reis, M. Fátima Namorado, Sónia Lupsa, Ioana-Rodica Gurzau, Anca E. Halzlova, Katarina Jajcaj, Michal Mazej, Darja Tratnik, Janja Snoj Lopez, Ana Cañas, Ana Lehmann, Andrea Crettaz, Pierre Den Hond, Elly Govarts, Eva |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Berglund, Marika Larsson, Kristin Grandér, Margaretha Casteleyn, Ludwine Kolossa-Gehring, Marike Schwedler, Gerda Castaño, Argelia Esteban, Marta Angerer, Jürgen Koch, Holger M. Schindler, Birgit K. Schoeters, Greet Smolders, Roel Exley, Karen Sepai, Ovnair Blumen, Luies Horvat, Milena Knudsen, Lisbeth E. Mørck, Thit A. Joas, Anke Joas, Reinhard Biot, Pierre Aerts, Dominique De Cremer, Koen Van Overmeire, Ilse Katsonouri, Andromachi Hadjipanayis, Adamos Cerna, Milena Krskova, Andrea Nielsen, Jeanette K. S. FangelJensen, Janne Rudnai, Peter Kozepesy, Szilvia Griffin, Chris Nesbitt, Ian Gutleb, Arno C. Fischer, Marc E. Ligocka, Danuta Jakubowski, Marek Reis, M. Fátima Namorado, Sónia Lupsa, Ioana-Rodica Gurzau, Anca E. Halzlova, Katarina Jajcaj, Michal Mazej, Darja Tratnik, Janja Snoj Lopez, Ana Cañas, Ana Lehmann, Andrea Crettaz, Pierre Den Hond, Elly Govarts, Eva |
| dc.subject.por.fl_str_mv |
Biomonitoring Mother–child pairs Urinary cadmium Exposure predictors DEMOCOPHES |
| topic |
Biomonitoring Mother–child pairs Urinary cadmium Exposure predictors DEMOCOPHES |
| description |
© 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CCBY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014-11-24T16:56:07Z 2014 2014-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/15333 |
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http://hdl.handle.net/10451/15333 |
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eng |
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eng |
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Environ. Res. (2014), http://dx.doi.org/10.1016/j.envres.2014.09.042i 0013-9351 http://dx.doi.org/10.1016/j.envres.2014.09.042 |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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mluisa.alvim@gmail.com |
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