The European COPHES/DEMOCOPHES project : towards transnational comparability and reliability of human biomonitoring results
| Autor(a) principal: | |
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| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/11512 |
Resumo: | © 2013 Elsevier GmbH. All rights reserved. |
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The European COPHES/DEMOCOPHES project : towards transnational comparability and reliability of human biomonitoring resultsCOPHESDEMOCOPHESBiomonitoringQuality assuranceBiomarkerUrine© 2013 Elsevier GmbH. All rights reserved.COPHES/DEMOCOPHES has its origins in the European Environment and Health Action Plan of 2004 to “develop a coherent approach on human biomonitoring (HBM) in Europe”. Within this twin-project it was targeted to collect specimens from 120 mother–child-pairs in each of the 17 participating Europeancountries. These specimens were investigated for six biomarkers (mercury in hair; creatinine, cotinine,cadmium, phthalate metabolites and bisphenol A in urine). The results for mercury in hair are described in a separate paper. Each participating member state was requested to contract laboratories, for capacity building reasons ideally within its borders, carrying out the chemical analyses. To ensure comparability of analytical data a Quality Assurance Unit (QAU) was established which provided the participating laboratories with standard operating procedures (SOP) and with control material. This material was specially prepared from native, non-spiked, pooled urine samples and was tested for homogeneity and stability.Four external quality assessment exercises were carried out. Highly esteemed laboratories from all over the world served as reference laboratories. Web conferences after each external quality assessment exercise functioned as a new and effective tool to improve analytical performance, to build capacity and to educate less experienced laboratories. Of the 38 laboratories participating in the quality assurance exercises 14 laboratories qualified for cadmium, 14 for creatinine, 9 for cotinine, 7 for phthalate metabolitesand 5 for bisphenol A in urine. In the last of the four external quality assessment exercises the laboratories that qualified for DEMOCOPHES performed the determinations in urine with relative standard deviations(low/high concentration) of 18.0/2.1% for cotinine, 14.8/5.1% for cadmium, 4.7/3.4% for creatinine. Relative standard deviations for the newly emerging biomarkers were higher, with values between 13.5 and 20.5% for bisphenol A and between 18.9 and 45.3% for the phthalate metabolites. Plausibility control of the HBM results of all participating countries disclosed analytical shortcomings in the determination of Cd when using certain ICP/MS methods. Results were corrected by reanalyzes. The COPHES/DEMOCOPHESproject for the first time succeeded in performing a harmonized pan-European HBM project. All data raised have to be regarded as utmost reliable according to the highest international state of the art, since highly renowned laboratories functioned as reference laboratories. The procedure described here, that has shown its success, can be used as a blueprint for future transnational, multicentre HBM projects.COPHES is funded under the 7th frameworkprogram of the EU (DG Research – No. 244237). DEMO-COPHES is funded 50% by Life+ 2009 (DG Environment – Life09ENV/BE000410) and the corresponding authorities in the participating countries.ElsevierRepositório da Universidade de LisboaSchindler, Birgit KarinEsteban, MartaKoch, Holger MartinCastano, ArgeliaKoslitz, StephanCañas, AnaCasteleyn, LudwineKolossa-Gehring, MarikeSchwedler, GerdaSchoeters, GreetHond, Elly DenSepai, OvnairExley, KarenBloemen, LouisHorvat, MilenaKnudsen, Lisbeth E.Joas, AnkeJoas, ReinhardBiot, PierreAerts, DominiqueLopez, AnaHuetos, OlgaKatsonouri, AndromachiMaurer-Chronakis, KatjaKasparova, LucieVrbík, KarelRudnai, PeterNaray, MiklosGuignard, CedricFischer, Marc E.Ligocka, DanutaJanasik, BeataReis, M. FátimaNamorado, SóniaPop, CristianDumitrascu, IrinaHalzlova, KatarinaFabianova, EleonoraMazej, DarjaTratnik, Janja SnojBerglund, MarikaJönsson, BoLehmann, AndreaCrettaz, PierreFrederiksen, HanneNielsen, FlemmingMcGrath, HelenaNesbitt, IanCremer, Koen DeVanermen, GuidoKoppen, GudrunWilhelm, MichaelBecker, KerstinAngerer, Jürgen2014-07-29T09:32:56Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/11512engInternational Journal of Hygiene and Environmental Health 217 (2014) 653–6611438-4639http://dx.doi.org/10.1016/j.ijheh.2013.12.002metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T15:57:45Zoai:repositorio.ul.pt:10451/11512Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:35:10.932855Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
The European COPHES/DEMOCOPHES project : towards transnational comparability and reliability of human biomonitoring results |
| title |
The European COPHES/DEMOCOPHES project : towards transnational comparability and reliability of human biomonitoring results |
| spellingShingle |
The European COPHES/DEMOCOPHES project : towards transnational comparability and reliability of human biomonitoring results Schindler, Birgit Karin COPHES DEMOCOPHES Biomonitoring Quality assurance Biomarker Urine |
| title_short |
The European COPHES/DEMOCOPHES project : towards transnational comparability and reliability of human biomonitoring results |
| title_full |
The European COPHES/DEMOCOPHES project : towards transnational comparability and reliability of human biomonitoring results |
| title_fullStr |
The European COPHES/DEMOCOPHES project : towards transnational comparability and reliability of human biomonitoring results |
| title_full_unstemmed |
The European COPHES/DEMOCOPHES project : towards transnational comparability and reliability of human biomonitoring results |
| title_sort |
The European COPHES/DEMOCOPHES project : towards transnational comparability and reliability of human biomonitoring results |
| author |
Schindler, Birgit Karin |
| author_facet |
Schindler, Birgit Karin Esteban, Marta Koch, Holger Martin Castano, Argelia Koslitz, Stephan Cañas, Ana Casteleyn, Ludwine Kolossa-Gehring, Marike Schwedler, Gerda Schoeters, Greet Hond, Elly Den Sepai, Ovnair Exley, Karen Bloemen, Louis Horvat, Milena Knudsen, Lisbeth E. Joas, Anke Joas, Reinhard Biot, Pierre Aerts, Dominique Lopez, Ana Huetos, Olga Katsonouri, Andromachi Maurer-Chronakis, Katja Kasparova, Lucie Vrbík, Karel Rudnai, Peter Naray, Miklos Guignard, Cedric Fischer, Marc E. Ligocka, Danuta Janasik, Beata Reis, M. Fátima Namorado, Sónia Pop, Cristian Dumitrascu, Irina Halzlova, Katarina Fabianova, Eleonora Mazej, Darja Tratnik, Janja Snoj Berglund, Marika Jönsson, Bo Lehmann, Andrea Crettaz, Pierre Frederiksen, Hanne Nielsen, Flemming McGrath, Helena Nesbitt, Ian Cremer, Koen De Vanermen, Guido Koppen, Gudrun Wilhelm, Michael Becker, Kerstin Angerer, Jürgen |
| author_role |
author |
| author2 |
Esteban, Marta Koch, Holger Martin Castano, Argelia Koslitz, Stephan Cañas, Ana Casteleyn, Ludwine Kolossa-Gehring, Marike Schwedler, Gerda Schoeters, Greet Hond, Elly Den Sepai, Ovnair Exley, Karen Bloemen, Louis Horvat, Milena Knudsen, Lisbeth E. Joas, Anke Joas, Reinhard Biot, Pierre Aerts, Dominique Lopez, Ana Huetos, Olga Katsonouri, Andromachi Maurer-Chronakis, Katja Kasparova, Lucie Vrbík, Karel Rudnai, Peter Naray, Miklos Guignard, Cedric Fischer, Marc E. Ligocka, Danuta Janasik, Beata Reis, M. Fátima Namorado, Sónia Pop, Cristian Dumitrascu, Irina Halzlova, Katarina Fabianova, Eleonora Mazej, Darja Tratnik, Janja Snoj Berglund, Marika Jönsson, Bo Lehmann, Andrea Crettaz, Pierre Frederiksen, Hanne Nielsen, Flemming McGrath, Helena Nesbitt, Ian Cremer, Koen De Vanermen, Guido Koppen, Gudrun Wilhelm, Michael Becker, Kerstin Angerer, Jürgen |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Schindler, Birgit Karin Esteban, Marta Koch, Holger Martin Castano, Argelia Koslitz, Stephan Cañas, Ana Casteleyn, Ludwine Kolossa-Gehring, Marike Schwedler, Gerda Schoeters, Greet Hond, Elly Den Sepai, Ovnair Exley, Karen Bloemen, Louis Horvat, Milena Knudsen, Lisbeth E. Joas, Anke Joas, Reinhard Biot, Pierre Aerts, Dominique Lopez, Ana Huetos, Olga Katsonouri, Andromachi Maurer-Chronakis, Katja Kasparova, Lucie Vrbík, Karel Rudnai, Peter Naray, Miklos Guignard, Cedric Fischer, Marc E. Ligocka, Danuta Janasik, Beata Reis, M. Fátima Namorado, Sónia Pop, Cristian Dumitrascu, Irina Halzlova, Katarina Fabianova, Eleonora Mazej, Darja Tratnik, Janja Snoj Berglund, Marika Jönsson, Bo Lehmann, Andrea Crettaz, Pierre Frederiksen, Hanne Nielsen, Flemming McGrath, Helena Nesbitt, Ian Cremer, Koen De Vanermen, Guido Koppen, Gudrun Wilhelm, Michael Becker, Kerstin Angerer, Jürgen |
| dc.subject.por.fl_str_mv |
COPHES DEMOCOPHES Biomonitoring Quality assurance Biomarker Urine |
| topic |
COPHES DEMOCOPHES Biomonitoring Quality assurance Biomarker Urine |
| description |
© 2013 Elsevier GmbH. All rights reserved. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014-07-29T09:32:56Z 2014 2014-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/11512 |
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http://hdl.handle.net/10451/11512 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
International Journal of Hygiene and Environmental Health 217 (2014) 653–661 1438-4639 http://dx.doi.org/10.1016/j.ijheh.2013.12.002 |
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metadata only access info:eu-repo/semantics/openAccess |
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metadata only access |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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