Electrochemical Oxidation of Metolazone at a Glassy Carbon Electrode
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/8252 https://doi.org/10.1002/elan.200804352 |
Resumo: | Metolazone is a diuretic agent used in patients with edematous states and/or hypertension. The electrochemical behavior of metolazone on a glassy carbon electrode was investigated using cyclic, differential pulse, and square-wave voltammetry at different pHs. The pH dependent oxidation of metolazone occurs in two consecutive steps in a diffusion-controlled mechanism and involves the formation of a main oxidation product. The first oxidation process is reversible, and involves two electrons and two protons corresponding to the oxidation of nitrogen in the sulfonamide moiety. The second oxidation process is irreversible, also occurs in the sulfonamide moiety, involves a one electron-transfer, and is followed by deprotonation to produce a cation radical, which reacts with water and yields a hydroxylated product. The diffusion coefficient of metolazone was calculated to be 3.43×10-6 cm2 s-1 in pH 7.0 0.1 M phosphate buffer. |
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Electrochemical Oxidation of Metolazone at a Glassy Carbon ElectrodeMetolazone is a diuretic agent used in patients with edematous states and/or hypertension. The electrochemical behavior of metolazone on a glassy carbon electrode was investigated using cyclic, differential pulse, and square-wave voltammetry at different pHs. The pH dependent oxidation of metolazone occurs in two consecutive steps in a diffusion-controlled mechanism and involves the formation of a main oxidation product. The first oxidation process is reversible, and involves two electrons and two protons corresponding to the oxidation of nitrogen in the sulfonamide moiety. The second oxidation process is irreversible, also occurs in the sulfonamide moiety, involves a one electron-transfer, and is followed by deprotonation to produce a cation radical, which reacts with water and yields a hydroxylated product. The diffusion coefficient of metolazone was calculated to be 3.43×10-6 cm2 s-1 in pH 7.0 0.1 M phosphate buffer.2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/8252http://hdl.handle.net/10316/8252https://doi.org/10.1002/elan.200804352engElectroanalysis. 9999:9999 (2008) NAPontinha, A. Dora R.Oliveira, S. Carlos B.Brett, Ana Maria Oliveirainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-05-25T13:15:09Zoai:estudogeral.uc.pt:10316/8252Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:01:28.577282Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Electrochemical Oxidation of Metolazone at a Glassy Carbon Electrode |
title |
Electrochemical Oxidation of Metolazone at a Glassy Carbon Electrode |
spellingShingle |
Electrochemical Oxidation of Metolazone at a Glassy Carbon Electrode Pontinha, A. Dora R. |
title_short |
Electrochemical Oxidation of Metolazone at a Glassy Carbon Electrode |
title_full |
Electrochemical Oxidation of Metolazone at a Glassy Carbon Electrode |
title_fullStr |
Electrochemical Oxidation of Metolazone at a Glassy Carbon Electrode |
title_full_unstemmed |
Electrochemical Oxidation of Metolazone at a Glassy Carbon Electrode |
title_sort |
Electrochemical Oxidation of Metolazone at a Glassy Carbon Electrode |
author |
Pontinha, A. Dora R. |
author_facet |
Pontinha, A. Dora R. Oliveira, S. Carlos B. Brett, Ana Maria Oliveira |
author_role |
author |
author2 |
Oliveira, S. Carlos B. Brett, Ana Maria Oliveira |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Pontinha, A. Dora R. Oliveira, S. Carlos B. Brett, Ana Maria Oliveira |
description |
Metolazone is a diuretic agent used in patients with edematous states and/or hypertension. The electrochemical behavior of metolazone on a glassy carbon electrode was investigated using cyclic, differential pulse, and square-wave voltammetry at different pHs. The pH dependent oxidation of metolazone occurs in two consecutive steps in a diffusion-controlled mechanism and involves the formation of a main oxidation product. The first oxidation process is reversible, and involves two electrons and two protons corresponding to the oxidation of nitrogen in the sulfonamide moiety. The second oxidation process is irreversible, also occurs in the sulfonamide moiety, involves a one electron-transfer, and is followed by deprotonation to produce a cation radical, which reacts with water and yields a hydroxylated product. The diffusion coefficient of metolazone was calculated to be 3.43×10-6 cm2 s-1 in pH 7.0 0.1 M phosphate buffer. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/8252 http://hdl.handle.net/10316/8252 https://doi.org/10.1002/elan.200804352 |
url |
http://hdl.handle.net/10316/8252 https://doi.org/10.1002/elan.200804352 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Electroanalysis. 9999:9999 (2008) NA |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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