Electrochemical oxidation of mitoxantrone at a glassy carbon electrode

Detalhes bibliográficos
Autor(a) principal: Brett, A. M. Oliveira
Data de Publicação: 1999
Outros Autores: Macedo, T. R. A., Raimundo, D., Marques, M. H., Serrano, S. H. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/5269
https://doi.org/10.1007/BF01206688
Resumo: Mitoxantrone is an anthracycline used as an antitumour antibiotic for leukaemia and breast cancer treatment, due to its interaction with DNA. However, the molecular mechanism of the antitumour action is not completely understood. Using a glassy carbon electrode the electrochemical oxidation of mitoxantrone was shown to be a complex, pH-dependent, irreversible electrode process involving several metabolites. Comparison of the electrochemical oxidation behaviour of mitoxantrone, ametantrone and aminantrone enabled a deeper understanding of the mechanism and showed the relevance of electrochemical data for the understanding of the cytotoxicity of mitoxantrone. Since mitoxantrone and its oxidation products adsorb strongly on the electrode surface, causing severe problems of electrode fouling, reproducible electroanalytical determinations could only be done at very low concentrations and in an aqueous buffer supporting electrolyte containing 30% ethanol. The detection limit obtained was 10-7 M.
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spelling Electrochemical oxidation of mitoxantrone at a glassy carbon electrodeBioelectrochemistryMitoxantrone oxidationVoltammetryMitoxantrone is an anthracycline used as an antitumour antibiotic for leukaemia and breast cancer treatment, due to its interaction with DNA. However, the molecular mechanism of the antitumour action is not completely understood. Using a glassy carbon electrode the electrochemical oxidation of mitoxantrone was shown to be a complex, pH-dependent, irreversible electrode process involving several metabolites. Comparison of the electrochemical oxidation behaviour of mitoxantrone, ametantrone and aminantrone enabled a deeper understanding of the mechanism and showed the relevance of electrochemical data for the understanding of the cytotoxicity of mitoxantrone. Since mitoxantrone and its oxidation products adsorb strongly on the electrode surface, causing severe problems of electrode fouling, reproducible electroanalytical determinations could only be done at very low concentrations and in an aqueous buffer supporting electrolyte containing 30% ethanol. The detection limit obtained was 10-7 M.http://www.sciencedirect.com/science/article/B6TF4-3W3N6Y2-1J/1/5ffa47da56de732d1903bdf9a6c163c91999info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/5269http://hdl.handle.net/10316/5269https://doi.org/10.1007/BF01206688engAnalytica Chimica Acta. 385:1-3 (1999) 401-408Brett, A. M. OliveiraMacedo, T. R. A.Raimundo, D.Marques, M. H.Serrano, S. H. P.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-09-22T09:26:24Zoai:estudogeral.uc.pt:10316/5269Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:01:38.951494Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Electrochemical oxidation of mitoxantrone at a glassy carbon electrode
title Electrochemical oxidation of mitoxantrone at a glassy carbon electrode
spellingShingle Electrochemical oxidation of mitoxantrone at a glassy carbon electrode
Brett, A. M. Oliveira
Bioelectrochemistry
Mitoxantrone oxidation
Voltammetry
title_short Electrochemical oxidation of mitoxantrone at a glassy carbon electrode
title_full Electrochemical oxidation of mitoxantrone at a glassy carbon electrode
title_fullStr Electrochemical oxidation of mitoxantrone at a glassy carbon electrode
title_full_unstemmed Electrochemical oxidation of mitoxantrone at a glassy carbon electrode
title_sort Electrochemical oxidation of mitoxantrone at a glassy carbon electrode
author Brett, A. M. Oliveira
author_facet Brett, A. M. Oliveira
Macedo, T. R. A.
Raimundo, D.
Marques, M. H.
Serrano, S. H. P.
author_role author
author2 Macedo, T. R. A.
Raimundo, D.
Marques, M. H.
Serrano, S. H. P.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Brett, A. M. Oliveira
Macedo, T. R. A.
Raimundo, D.
Marques, M. H.
Serrano, S. H. P.
dc.subject.por.fl_str_mv Bioelectrochemistry
Mitoxantrone oxidation
Voltammetry
topic Bioelectrochemistry
Mitoxantrone oxidation
Voltammetry
description Mitoxantrone is an anthracycline used as an antitumour antibiotic for leukaemia and breast cancer treatment, due to its interaction with DNA. However, the molecular mechanism of the antitumour action is not completely understood. Using a glassy carbon electrode the electrochemical oxidation of mitoxantrone was shown to be a complex, pH-dependent, irreversible electrode process involving several metabolites. Comparison of the electrochemical oxidation behaviour of mitoxantrone, ametantrone and aminantrone enabled a deeper understanding of the mechanism and showed the relevance of electrochemical data for the understanding of the cytotoxicity of mitoxantrone. Since mitoxantrone and its oxidation products adsorb strongly on the electrode surface, causing severe problems of electrode fouling, reproducible electroanalytical determinations could only be done at very low concentrations and in an aqueous buffer supporting electrolyte containing 30% ethanol. The detection limit obtained was 10-7 M.
publishDate 1999
dc.date.none.fl_str_mv 1999
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/5269
http://hdl.handle.net/10316/5269
https://doi.org/10.1007/BF01206688
url http://hdl.handle.net/10316/5269
https://doi.org/10.1007/BF01206688
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Analytica Chimica Acta. 385:1-3 (1999) 401-408
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv aplication/PDF
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