Monocarboxylate transporters as targets and mediators in cancer therapy response

Detalhes bibliográficos
Autor(a) principal: Baltazar, Fátima
Data de Publicação: 2014
Outros Autores: Pinheiro, Céline, Santos, Filipa Morais, Silva, J. Azevedo, Queirós, Odília, Preto, Ana, Casal, Margarida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/32518
Resumo: Proofs
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spelling Monocarboxylate transporters as targets and mediators in cancer therapy responseMonocarboxylate transportersCancer therapyGlycolysisMolecular targetsScience & TechnologyProofsMonocarboxylate transporters (MCTs) belong to a family of transporters, encoded by the SLC16 gene family, which is presently composed by 14 members, but only MCT1 to 4 have been biochemically characterized. They have important functions in healthy tissues, being involved in the transmembrane transport of lactic acid and other monocarboxylic acids in human cells. One of the recently recognized hallmarks of cancer is altered metabolism, with high rates of glucose consumption and consequent lactate production. To maintain this metabolic phenotype, cancer cells upregulate a series of plasma membrane proteins, including MCTs. MCT1 and MCT4, in particular, play a dual role in the maintenance of the metabolic phenotype of tumour cells. On one hand, they facilitate the efflux of lactate and, on the other hand, they contribute to the preservation of the intracellular pH, by co-transporting a proton. Thus, MCTs are attractive targets in cancer therapy, especially in cancers with a hyper-glycolytic and acid-resistant phenotype. Recent evidence demonstrates that MCTs are involved in cancer cell uptake of chemotherapeutic agents, including 3-bromopyruvate. In this way MCTs can act as "Trojan horses", as their elevated expression in cancer cells can mediate the entry of this chemotherapeutic agent into the cells and selectively kill cancer cells. As a result, MCTs will be mediators of chemotherapeutic response, and their expression can be used as a molecular marker to predict response to chemotherapy.F HernandezUniversidade do MinhoBaltazar, FátimaPinheiro, CélineSantos, Filipa MoraisSilva, J. AzevedoQueirós, OdíliaPreto, AnaCasal, Margarida20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/32518eng0213-391124921258http://www.hh.um.es/Forthcoming_original_articles.htminfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:23:06Zoai:repositorium.sdum.uminho.pt:1822/32518Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:16:44.238536Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Monocarboxylate transporters as targets and mediators in cancer therapy response
title Monocarboxylate transporters as targets and mediators in cancer therapy response
spellingShingle Monocarboxylate transporters as targets and mediators in cancer therapy response
Baltazar, Fátima
Monocarboxylate transporters
Cancer therapy
Glycolysis
Molecular targets
Science & Technology
title_short Monocarboxylate transporters as targets and mediators in cancer therapy response
title_full Monocarboxylate transporters as targets and mediators in cancer therapy response
title_fullStr Monocarboxylate transporters as targets and mediators in cancer therapy response
title_full_unstemmed Monocarboxylate transporters as targets and mediators in cancer therapy response
title_sort Monocarboxylate transporters as targets and mediators in cancer therapy response
author Baltazar, Fátima
author_facet Baltazar, Fátima
Pinheiro, Céline
Santos, Filipa Morais
Silva, J. Azevedo
Queirós, Odília
Preto, Ana
Casal, Margarida
author_role author
author2 Pinheiro, Céline
Santos, Filipa Morais
Silva, J. Azevedo
Queirós, Odília
Preto, Ana
Casal, Margarida
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Baltazar, Fátima
Pinheiro, Céline
Santos, Filipa Morais
Silva, J. Azevedo
Queirós, Odília
Preto, Ana
Casal, Margarida
dc.subject.por.fl_str_mv Monocarboxylate transporters
Cancer therapy
Glycolysis
Molecular targets
Science & Technology
topic Monocarboxylate transporters
Cancer therapy
Glycolysis
Molecular targets
Science & Technology
description Proofs
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/32518
url http://hdl.handle.net/1822/32518
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0213-3911
24921258
http://www.hh.um.es/Forthcoming_original_articles.htm
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv F Hernandez
publisher.none.fl_str_mv F Hernandez
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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