Monocarboxylate transporters as targets and mediators in cancer therapy response
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/32518 |
Resumo: | Proofs |
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Monocarboxylate transporters as targets and mediators in cancer therapy responseMonocarboxylate transportersCancer therapyGlycolysisMolecular targetsScience & TechnologyProofsMonocarboxylate transporters (MCTs) belong to a family of transporters, encoded by the SLC16 gene family, which is presently composed by 14 members, but only MCT1 to 4 have been biochemically characterized. They have important functions in healthy tissues, being involved in the transmembrane transport of lactic acid and other monocarboxylic acids in human cells. One of the recently recognized hallmarks of cancer is altered metabolism, with high rates of glucose consumption and consequent lactate production. To maintain this metabolic phenotype, cancer cells upregulate a series of plasma membrane proteins, including MCTs. MCT1 and MCT4, in particular, play a dual role in the maintenance of the metabolic phenotype of tumour cells. On one hand, they facilitate the efflux of lactate and, on the other hand, they contribute to the preservation of the intracellular pH, by co-transporting a proton. Thus, MCTs are attractive targets in cancer therapy, especially in cancers with a hyper-glycolytic and acid-resistant phenotype. Recent evidence demonstrates that MCTs are involved in cancer cell uptake of chemotherapeutic agents, including 3-bromopyruvate. In this way MCTs can act as "Trojan horses", as their elevated expression in cancer cells can mediate the entry of this chemotherapeutic agent into the cells and selectively kill cancer cells. As a result, MCTs will be mediators of chemotherapeutic response, and their expression can be used as a molecular marker to predict response to chemotherapy.F HernandezUniversidade do MinhoBaltazar, FátimaPinheiro, CélineSantos, Filipa MoraisSilva, J. AzevedoQueirós, OdíliaPreto, AnaCasal, Margarida20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/32518eng0213-391124921258http://www.hh.um.es/Forthcoming_original_articles.htminfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:23:06Zoai:repositorium.sdum.uminho.pt:1822/32518Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:16:44.238536Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Monocarboxylate transporters as targets and mediators in cancer therapy response |
title |
Monocarboxylate transporters as targets and mediators in cancer therapy response |
spellingShingle |
Monocarboxylate transporters as targets and mediators in cancer therapy response Baltazar, Fátima Monocarboxylate transporters Cancer therapy Glycolysis Molecular targets Science & Technology |
title_short |
Monocarboxylate transporters as targets and mediators in cancer therapy response |
title_full |
Monocarboxylate transporters as targets and mediators in cancer therapy response |
title_fullStr |
Monocarboxylate transporters as targets and mediators in cancer therapy response |
title_full_unstemmed |
Monocarboxylate transporters as targets and mediators in cancer therapy response |
title_sort |
Monocarboxylate transporters as targets and mediators in cancer therapy response |
author |
Baltazar, Fátima |
author_facet |
Baltazar, Fátima Pinheiro, Céline Santos, Filipa Morais Silva, J. Azevedo Queirós, Odília Preto, Ana Casal, Margarida |
author_role |
author |
author2 |
Pinheiro, Céline Santos, Filipa Morais Silva, J. Azevedo Queirós, Odília Preto, Ana Casal, Margarida |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Baltazar, Fátima Pinheiro, Céline Santos, Filipa Morais Silva, J. Azevedo Queirós, Odília Preto, Ana Casal, Margarida |
dc.subject.por.fl_str_mv |
Monocarboxylate transporters Cancer therapy Glycolysis Molecular targets Science & Technology |
topic |
Monocarboxylate transporters Cancer therapy Glycolysis Molecular targets Science & Technology |
description |
Proofs |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/32518 |
url |
http://hdl.handle.net/1822/32518 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0213-3911 24921258 http://www.hh.um.es/Forthcoming_original_articles.htm |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
F Hernandez |
publisher.none.fl_str_mv |
F Hernandez |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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