Toxicological and pharmacological evaluation of the essential oil and aqueous extract of Lavandula stoechas L. subsp. luisieri

Detalhes bibliográficos
Autor(a) principal: Arantes, Silvia
Data de Publicação: 2013
Outros Autores: Candeias, M. Fátima, Pereira, Marizia, Lopes, Orlando, Lima, Mónica, Martins, M. Rosário
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10174/9788
Resumo: Lavenders belong to the family Labiatae and represent some of the most popular medicinal plants extensively used in aromatherapy. In this study, we selected Lavandula stoechas L. subsp. luisieri (Rozeira) Rozeira, endemic of Portugal, collected in Évora (Alentejo). The aim of this study was to evaluate the acute toxicity and the analgesic and anti-inflammatory activities of the essential oil and aqueous extract from leaves of L. luisieri. The essential oil was obtained by hydrodistillation in Clevenger type apparatus and the resulting hydrolate was lyophilized. Chemical composition of essential oil was evaluated by GC/FID and extract was characterized by phytochemical tests and total phenolics and flavonoids quantification. Acute toxicity was evaluated in vitro in brine shrimp (LC50) and in vivo in Swiss mice, by pharmacological screening, determination of LD50, according to Up-and-Down OECD Procedure and liver and kidney histopathological study. Pharmacological properties, namely, analgesic and anti- inflammatory activities were evaluated in rats.
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spelling Toxicological and pharmacological evaluation of the essential oil and aqueous extract of Lavandula stoechas L. subsp. luisieriLavandula stoechas ssp. luisieriessential oiltoxicological evaluationfarmacological actvityLavenders belong to the family Labiatae and represent some of the most popular medicinal plants extensively used in aromatherapy. In this study, we selected Lavandula stoechas L. subsp. luisieri (Rozeira) Rozeira, endemic of Portugal, collected in Évora (Alentejo). The aim of this study was to evaluate the acute toxicity and the analgesic and anti-inflammatory activities of the essential oil and aqueous extract from leaves of L. luisieri. The essential oil was obtained by hydrodistillation in Clevenger type apparatus and the resulting hydrolate was lyophilized. Chemical composition of essential oil was evaluated by GC/FID and extract was characterized by phytochemical tests and total phenolics and flavonoids quantification. Acute toxicity was evaluated in vitro in brine shrimp (LC50) and in vivo in Swiss mice, by pharmacological screening, determination of LD50, according to Up-and-Down OECD Procedure and liver and kidney histopathological study. Pharmacological properties, namely, analgesic and anti- inflammatory activities were evaluated in rats.Universidade de Aveiro2014-01-20T17:17:59Z2014-01-202013-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/9788http://hdl.handle.net/10174/9788engArantes S, Candeias MF, Pereira M, Lopes, O., Lima, M., Cruz-Morais J., Martins MR (2013). Toxicological and pharmacological evaluation of the essential oil and aqueous extract of Lavandula stoechas L. subsp. luisieri. Livro de Resumos do MicroBiotec, pp 303, Aveiro, PortugalAbstrats Book of MicroBiotec´13saa@uevora.ptmfbc@uevora.ptmariziacmdp3@gmail.comosl@uevora.ptmopl@uevora.ptmrm@uevora.pt576Arantes, SilviaCandeias, M. FátimaPereira, MariziaLopes, OrlandoLima, MónicaMartins, M. Rosárioinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T18:52:01Zoai:dspace.uevora.pt:10174/9788Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:03:47.976481Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Toxicological and pharmacological evaluation of the essential oil and aqueous extract of Lavandula stoechas L. subsp. luisieri
title Toxicological and pharmacological evaluation of the essential oil and aqueous extract of Lavandula stoechas L. subsp. luisieri
spellingShingle Toxicological and pharmacological evaluation of the essential oil and aqueous extract of Lavandula stoechas L. subsp. luisieri
Arantes, Silvia
Lavandula stoechas ssp. luisieri
essential oil
toxicological evaluation
farmacological actvity
title_short Toxicological and pharmacological evaluation of the essential oil and aqueous extract of Lavandula stoechas L. subsp. luisieri
title_full Toxicological and pharmacological evaluation of the essential oil and aqueous extract of Lavandula stoechas L. subsp. luisieri
title_fullStr Toxicological and pharmacological evaluation of the essential oil and aqueous extract of Lavandula stoechas L. subsp. luisieri
title_full_unstemmed Toxicological and pharmacological evaluation of the essential oil and aqueous extract of Lavandula stoechas L. subsp. luisieri
title_sort Toxicological and pharmacological evaluation of the essential oil and aqueous extract of Lavandula stoechas L. subsp. luisieri
author Arantes, Silvia
author_facet Arantes, Silvia
Candeias, M. Fátima
Pereira, Marizia
Lopes, Orlando
Lima, Mónica
Martins, M. Rosário
author_role author
author2 Candeias, M. Fátima
Pereira, Marizia
Lopes, Orlando
Lima, Mónica
Martins, M. Rosário
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Arantes, Silvia
Candeias, M. Fátima
Pereira, Marizia
Lopes, Orlando
Lima, Mónica
Martins, M. Rosário
dc.subject.por.fl_str_mv Lavandula stoechas ssp. luisieri
essential oil
toxicological evaluation
farmacological actvity
topic Lavandula stoechas ssp. luisieri
essential oil
toxicological evaluation
farmacological actvity
description Lavenders belong to the family Labiatae and represent some of the most popular medicinal plants extensively used in aromatherapy. In this study, we selected Lavandula stoechas L. subsp. luisieri (Rozeira) Rozeira, endemic of Portugal, collected in Évora (Alentejo). The aim of this study was to evaluate the acute toxicity and the analgesic and anti-inflammatory activities of the essential oil and aqueous extract from leaves of L. luisieri. The essential oil was obtained by hydrodistillation in Clevenger type apparatus and the resulting hydrolate was lyophilized. Chemical composition of essential oil was evaluated by GC/FID and extract was characterized by phytochemical tests and total phenolics and flavonoids quantification. Acute toxicity was evaluated in vitro in brine shrimp (LC50) and in vivo in Swiss mice, by pharmacological screening, determination of LD50, according to Up-and-Down OECD Procedure and liver and kidney histopathological study. Pharmacological properties, namely, analgesic and anti- inflammatory activities were evaluated in rats.
publishDate 2013
dc.date.none.fl_str_mv 2013-12-01T00:00:00Z
2014-01-20T17:17:59Z
2014-01-20
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10174/9788
http://hdl.handle.net/10174/9788
url http://hdl.handle.net/10174/9788
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arantes S, Candeias MF, Pereira M, Lopes, O., Lima, M., Cruz-Morais J., Martins MR (2013). Toxicological and pharmacological evaluation of the essential oil and aqueous extract of Lavandula stoechas L. subsp. luisieri. Livro de Resumos do MicroBiotec, pp 303, Aveiro, Portugal
Abstrats Book of MicroBiotec´13
saa@uevora.pt
mfbc@uevora.pt
mariziacmdp3@gmail.com
osl@uevora.pt
mopl@uevora.pt
mrm@uevora.pt
576
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade de Aveiro
publisher.none.fl_str_mv Universidade de Aveiro
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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