Micro RNAs in Tfh regulation : small molecules with a big impact

Detalhes bibliográficos
Autor(a) principal: Basto, Afonso P.
Data de Publicação: 2021
Outros Autores: Graca, Luis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/23172
Resumo: Research Areas: Immunology
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spelling Micro RNAs in Tfh regulation : small molecules with a big impactMicro RNAsT follicular helper cellsT follicular regulatory cellsGerminal centerResearch Areas: ImmunologyABSTRACT - The germinal center (GC) reactions are critical for the production of high-affinity antibodies that comprise the protective humoral response elicited by infection or vaccination. GCs are initiated through the interaction of B cells with T follicular helper (Tfh) cells. While the transcriptional regulation of Tfh differentiation has been studied in great detail, the impact of micro RNAs (miRNAs) on Tfh development and stability has been harder to address. It was previously shown that a complete deletion of miRNAs biogenesis prevents Tfh differentiation. In this issue of the European Journal of Immunology [Eur. J. Immunol. 2021. 51: 408-413], Zeiträg et al. use an inducible gene deletion approach to reveal that miRNAs are also required for the maintenance of Tfh cells induced following viral infection in mice. These results provide new clues to the regulation of GC responses through Tfh and T follicular regulatory cells.WileyRepositório da Universidade de LisboaBasto, Afonso P.Graca, Luis2022-01-19T17:58:17Z2021-022021-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/23172engBasto AP, Graça L. 2021. Micro RNAs in Tfh regulation : small molecules with a big impact. European Journal of Immunology. 51(2):p. 292-2950014-298010.1002/eji.2020490861521-4141info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:36:08Zoai:repositorio.ul.pt:10400.5/23172Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:36:08Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Micro RNAs in Tfh regulation : small molecules with a big impact
title Micro RNAs in Tfh regulation : small molecules with a big impact
spellingShingle Micro RNAs in Tfh regulation : small molecules with a big impact
Basto, Afonso P.
Micro RNAs
T follicular helper cells
T follicular regulatory cells
Germinal center
title_short Micro RNAs in Tfh regulation : small molecules with a big impact
title_full Micro RNAs in Tfh regulation : small molecules with a big impact
title_fullStr Micro RNAs in Tfh regulation : small molecules with a big impact
title_full_unstemmed Micro RNAs in Tfh regulation : small molecules with a big impact
title_sort Micro RNAs in Tfh regulation : small molecules with a big impact
author Basto, Afonso P.
author_facet Basto, Afonso P.
Graca, Luis
author_role author
author2 Graca, Luis
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Basto, Afonso P.
Graca, Luis
dc.subject.por.fl_str_mv Micro RNAs
T follicular helper cells
T follicular regulatory cells
Germinal center
topic Micro RNAs
T follicular helper cells
T follicular regulatory cells
Germinal center
description Research Areas: Immunology
publishDate 2021
dc.date.none.fl_str_mv 2021-02
2021-02-01T00:00:00Z
2022-01-19T17:58:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/23172
url http://hdl.handle.net/10400.5/23172
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Basto AP, Graça L. 2021. Micro RNAs in Tfh regulation : small molecules with a big impact. European Journal of Immunology. 51(2):p. 292-295
0014-2980
10.1002/eji.202049086
1521-4141
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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