Plasmodium vivax infection changes the peripheral immunoregulatory network

Detalhes bibliográficos
Autor(a) principal: Ferreira, Natália S
Data de Publicação: 2023
Outros Autores: Lima, Nathália F, Sulczewski, Fernando B., Soares, Irene S., Ferreira, Marcelo U., Boscardin, Silvia B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/154455
Resumo: © 2023 Wiley-VCH GmbH.
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spelling Plasmodium vivax infection changes the peripheral immunoregulatory networkCD4 T follicular cells and B cellsCTLA-4Memory B cellsPlasmodium vivaxT follicular helper (Tfh) cellsT follicular regulatory (Tfr) cellsR MedicineQR180 ImmunologyQR MicrobiologyImmunologyParasitologyInfectious DiseasesSDG 3 - Good Health and Well-being© 2023 Wiley-VCH GmbH.Regulatory and effector cell responses to Plasmodium vivax, the most common human malaria parasite outside Africa, remain understudied in naturally infected populations. Here, we describe peripheral CD4 + T- and B-cell populations during and shortly after an uncomplicated P. vivax infection in 38 continuously exposed adult Amazonians. Consistent with previous observations, we found an increased frequency in CD4 + CD45RA - CD25 + FoxP3 + T regulatory cells that express the inhibitory molecule CTLA-4 during the acute infection, with a sustained expansion of CD21 - CD27 - atypical memory cells within the CD19 + B-cell compartment. Both Th1- and Th2-type subsets of CXCR5 + ICOS hi PD-1 + circulating T follicular helper (cTfh) cells, which are thought to contribute to antibody production, were induced during P. vivax infection, with a positive correlation between overall cTfh cell frequency and IgG antibody titers to the P. vivax blood-stage antigen MSP1 19 . We identified significant changes in cell populations that had not been described in human malaria, such as an increased frequency of CTLA-4 + T follicular regulatory cells that antagonize Tfh cells, and a decreased frequency of circulating CD24 hi CD27 + B regulatory cells in response to acute infection. In conclusion, we disclose a complex immunoregulatory network that is critical to understand how naturally acquired immunity develops in P. vivax malaria.Individual Health Care (IHC)Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)RUNFerreira, Natália SLima, Nathália FSulczewski, Fernando B.Soares, Irene S.Ferreira, Marcelo U.Boscardin, Silvia B.2023-06-26T22:15:02Z2023-05-092023-05-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/154455eng0014-2980PURE: 63157257https://doi.org/10.1002/eji.202350372info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:36:52Zoai:run.unl.pt:10362/154455Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:37.244157Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Plasmodium vivax infection changes the peripheral immunoregulatory network
CD4 T follicular cells and B cells
title Plasmodium vivax infection changes the peripheral immunoregulatory network
spellingShingle Plasmodium vivax infection changes the peripheral immunoregulatory network
Ferreira, Natália S
CTLA-4
Memory B cells
Plasmodium vivax
T follicular helper (Tfh) cells
T follicular regulatory (Tfr) cells
R Medicine
QR180 Immunology
QR Microbiology
Immunology
Parasitology
Infectious Diseases
SDG 3 - Good Health and Well-being
title_short Plasmodium vivax infection changes the peripheral immunoregulatory network
title_full Plasmodium vivax infection changes the peripheral immunoregulatory network
title_fullStr Plasmodium vivax infection changes the peripheral immunoregulatory network
title_full_unstemmed Plasmodium vivax infection changes the peripheral immunoregulatory network
title_sort Plasmodium vivax infection changes the peripheral immunoregulatory network
author Ferreira, Natália S
author_facet Ferreira, Natália S
Lima, Nathália F
Sulczewski, Fernando B.
Soares, Irene S.
Ferreira, Marcelo U.
Boscardin, Silvia B.
author_role author
author2 Lima, Nathália F
Sulczewski, Fernando B.
Soares, Irene S.
Ferreira, Marcelo U.
Boscardin, Silvia B.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Individual Health Care (IHC)
Global Health and Tropical Medicine (GHTM)
Instituto de Higiene e Medicina Tropical (IHMT)
RUN
dc.contributor.author.fl_str_mv Ferreira, Natália S
Lima, Nathália F
Sulczewski, Fernando B.
Soares, Irene S.
Ferreira, Marcelo U.
Boscardin, Silvia B.
dc.subject.por.fl_str_mv CTLA-4
Memory B cells
Plasmodium vivax
T follicular helper (Tfh) cells
T follicular regulatory (Tfr) cells
R Medicine
QR180 Immunology
QR Microbiology
Immunology
Parasitology
Infectious Diseases
SDG 3 - Good Health and Well-being
topic CTLA-4
Memory B cells
Plasmodium vivax
T follicular helper (Tfh) cells
T follicular regulatory (Tfr) cells
R Medicine
QR180 Immunology
QR Microbiology
Immunology
Parasitology
Infectious Diseases
SDG 3 - Good Health and Well-being
description © 2023 Wiley-VCH GmbH.
publishDate 2023
dc.date.none.fl_str_mv 2023-06-26T22:15:02Z
2023-05-09
2023-05-09T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/154455
url http://hdl.handle.net/10362/154455
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0014-2980
PURE: 63157257
https://doi.org/10.1002/eji.202350372
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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