Occupational exposure to mycotoxins in swine production

Detalhes bibliográficos
Autor(a) principal: Viegas, Susana
Data de Publicação: 2019
Outros Autores: Assunção, Ricardo, Martins, Carla, Nunes, Carla, Osteresch, Bernd, Twarużek, Magdalena, Kosicki, Robert, Grajewski, Jan, Ribeiro, Edna, Viegas, Carla
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.3390/toxins11020078
Resumo: Swine production workers are exposed simultaneously to multiple contaminants. Occupational exposure to aflatoxin B1 (AFB 1 ) in Portuguese swine production farms has already been reported. However, besides AFB1, data regarding fungal contamination showed that exposure to other mycotoxins could be expected in this setting. The present study aimed to characterize the occupational exposure to multiple mycotoxins of swine production workers. To provide a broad view on the burden of contamination by mycotoxins and the workers’ exposure, biological (urine) samples from workers (n = 25) and 38 environmental samples (air samples, n = 23; litter samples, n = 5; feed samples, n = 10) were collected. The mycotoxins biomarkers detected in the urine samples of the workers group were the deoxynivalenol-glucuronic acid conjugate (60%), aflatoxin M1 (16%), enniatin B (4%), citrinin (8%), dihydrocitrinone (12%) and ochratoxin A (80%). Results of the control group followed the same pattern, but in general with a lower number of quantifiable results (<LOQ). Besides air samples, all the other environmental samples collected presented high and diverse contamination, and deoxynivalenol (DON), like in the biomonitoring results, was the most prominent mycotoxin. The results demonstrate that the occupational environment is adding and contributing to the workers’ total exposure to mycotoxins, particularly in the case of DON. This was confirmed by the biomonitoring data and the high contamination found in feed and litter samples. Furthermore, he followed multi-biomarker approach allowed to conclude that workers and general population are exposed to several mycotoxins simultaneously. Moreover, occupational exposure is probably described as being intermittent and with very high concentrations for short durations. This should be reflected in the risk assessment process.
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spelling Occupational exposure to mycotoxins in swine productionenvironmental and biological monitoring approachesBiomonitoringMycotoxinsMycotoxins mixtureOccupational exposureSwine productionToxicologyHealth, Toxicology and MutagenesisSwine production workers are exposed simultaneously to multiple contaminants. Occupational exposure to aflatoxin B1 (AFB 1 ) in Portuguese swine production farms has already been reported. However, besides AFB1, data regarding fungal contamination showed that exposure to other mycotoxins could be expected in this setting. The present study aimed to characterize the occupational exposure to multiple mycotoxins of swine production workers. To provide a broad view on the burden of contamination by mycotoxins and the workers’ exposure, biological (urine) samples from workers (n = 25) and 38 environmental samples (air samples, n = 23; litter samples, n = 5; feed samples, n = 10) were collected. The mycotoxins biomarkers detected in the urine samples of the workers group were the deoxynivalenol-glucuronic acid conjugate (60%), aflatoxin M1 (16%), enniatin B (4%), citrinin (8%), dihydrocitrinone (12%) and ochratoxin A (80%). Results of the control group followed the same pattern, but in general with a lower number of quantifiable results (<LOQ). Besides air samples, all the other environmental samples collected presented high and diverse contamination, and deoxynivalenol (DON), like in the biomonitoring results, was the most prominent mycotoxin. The results demonstrate that the occupational environment is adding and contributing to the workers’ total exposure to mycotoxins, particularly in the case of DON. This was confirmed by the biomonitoring data and the high contamination found in feed and litter samples. Furthermore, he followed multi-biomarker approach allowed to conclude that workers and general population are exposed to several mycotoxins simultaneously. Moreover, occupational exposure is probably described as being intermittent and with very high concentrations for short durations. This should be reflected in the risk assessment process.Centro de Investigação em Saúde Pública (CISP/PHRC)Escola Nacional de Saúde Pública (ENSP)RUNViegas, SusanaAssunção, RicardoMartins, CarlaNunes, CarlaOsteresch, BerndTwarużek, MagdalenaKosicki, RobertGrajewski, JanRibeiro, EdnaViegas, Carla2019-04-23T22:18:50Z2019-02-012019-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.3390/toxins11020078eng2072-6651PURE: 12896359http://www.scopus.com/inward/record.url?scp=85061123662&partnerID=8YFLogxKhttps://doi.org/10.3390/toxins11020078info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:31:54Zoai:run.unl.pt:10362/67499Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:34:37.478578Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Occupational exposure to mycotoxins in swine production
environmental and biological monitoring approaches
title Occupational exposure to mycotoxins in swine production
spellingShingle Occupational exposure to mycotoxins in swine production
Viegas, Susana
Biomonitoring
Mycotoxins
Mycotoxins mixture
Occupational exposure
Swine production
Toxicology
Health, Toxicology and Mutagenesis
title_short Occupational exposure to mycotoxins in swine production
title_full Occupational exposure to mycotoxins in swine production
title_fullStr Occupational exposure to mycotoxins in swine production
title_full_unstemmed Occupational exposure to mycotoxins in swine production
title_sort Occupational exposure to mycotoxins in swine production
author Viegas, Susana
author_facet Viegas, Susana
Assunção, Ricardo
Martins, Carla
Nunes, Carla
Osteresch, Bernd
Twarużek, Magdalena
Kosicki, Robert
Grajewski, Jan
Ribeiro, Edna
Viegas, Carla
author_role author
author2 Assunção, Ricardo
Martins, Carla
Nunes, Carla
Osteresch, Bernd
Twarużek, Magdalena
Kosicki, Robert
Grajewski, Jan
Ribeiro, Edna
Viegas, Carla
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Investigação em Saúde Pública (CISP/PHRC)
Escola Nacional de Saúde Pública (ENSP)
RUN
dc.contributor.author.fl_str_mv Viegas, Susana
Assunção, Ricardo
Martins, Carla
Nunes, Carla
Osteresch, Bernd
Twarużek, Magdalena
Kosicki, Robert
Grajewski, Jan
Ribeiro, Edna
Viegas, Carla
dc.subject.por.fl_str_mv Biomonitoring
Mycotoxins
Mycotoxins mixture
Occupational exposure
Swine production
Toxicology
Health, Toxicology and Mutagenesis
topic Biomonitoring
Mycotoxins
Mycotoxins mixture
Occupational exposure
Swine production
Toxicology
Health, Toxicology and Mutagenesis
description Swine production workers are exposed simultaneously to multiple contaminants. Occupational exposure to aflatoxin B1 (AFB 1 ) in Portuguese swine production farms has already been reported. However, besides AFB1, data regarding fungal contamination showed that exposure to other mycotoxins could be expected in this setting. The present study aimed to characterize the occupational exposure to multiple mycotoxins of swine production workers. To provide a broad view on the burden of contamination by mycotoxins and the workers’ exposure, biological (urine) samples from workers (n = 25) and 38 environmental samples (air samples, n = 23; litter samples, n = 5; feed samples, n = 10) were collected. The mycotoxins biomarkers detected in the urine samples of the workers group were the deoxynivalenol-glucuronic acid conjugate (60%), aflatoxin M1 (16%), enniatin B (4%), citrinin (8%), dihydrocitrinone (12%) and ochratoxin A (80%). Results of the control group followed the same pattern, but in general with a lower number of quantifiable results (<LOQ). Besides air samples, all the other environmental samples collected presented high and diverse contamination, and deoxynivalenol (DON), like in the biomonitoring results, was the most prominent mycotoxin. The results demonstrate that the occupational environment is adding and contributing to the workers’ total exposure to mycotoxins, particularly in the case of DON. This was confirmed by the biomonitoring data and the high contamination found in feed and litter samples. Furthermore, he followed multi-biomarker approach allowed to conclude that workers and general population are exposed to several mycotoxins simultaneously. Moreover, occupational exposure is probably described as being intermittent and with very high concentrations for short durations. This should be reflected in the risk assessment process.
publishDate 2019
dc.date.none.fl_str_mv 2019-04-23T22:18:50Z
2019-02-01
2019-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.3390/toxins11020078
url https://doi.org/10.3390/toxins11020078
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2072-6651
PURE: 12896359
http://www.scopus.com/inward/record.url?scp=85061123662&partnerID=8YFLogxK
https://doi.org/10.3390/toxins11020078
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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