Occupational Exposure to Mycotoxins in Swine Production: Environmental and Biological Monitoring Approaches

Detalhes bibliográficos
Autor(a) principal: Viegas, S.
Data de Publicação: 2019
Outros Autores: Assunção, R., Martins, Carla, Nunes, Carla, Osteresch, Bernd, Twaruzek, Magdalena, Kosicki, Robert, Grajewski, Jan, Ribeiro, Edna, Viegas, C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/6545
Resumo: Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30717100/
id RCAP_1371ce2b4d5da28d3cf7ce02183084b9
oai_identifier_str oai:repositorio.insa.pt:10400.18/6545
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Occupational Exposure to Mycotoxins in Swine Production: Environmental and Biological Monitoring ApproachesMicotoxinsBiomonitoringMycotoxins MixtureOccupational ExposureSwine ProductionMicotoxinasSegurança AlimentarToxicologiaAvaliação de RiscoSaúde HumanaFree PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30717100/The authors are grateful to the swine farms employers and workers that collaborate in this research project. R.A. and C.M. are grateful to INSA and to CESAM (UID/AMB/50017/2013) through national funds (FCT), and the co-funding by the Fundo Europeu de Desenvolvimento Regional (FEDER) (POCI-01-0145-FEDER-00763), within the PT2020 Partnership Agreement and Compete 2020.Swine production workers are exposed simultaneously to multiple contaminants. Occupational exposure to aflatoxin B1 (AFB1) in Portuguese swine production farms has already been reported. However, besides AFB1, data regarding fungal contamination showed that exposure to other mycotoxins could be expected in this setting. The present study aimed to characterize the occupational exposure to multiple mycotoxins of swine production workers. To provide a broad view on the burden of contamination by mycotoxins and the workers’ exposure, biological (urine) samples from workers (n = 25) and 38 environmental samples (air samples, n = 23; litter samples, n = 5; feed samples, n = 10) were collected. The mycotoxins biomarkers detected in the urine samples of the workers group were the deoxynivalenol-glucuronic acid conjugate (60%), aflatoxin M1 (16%), enniatin B (4%), citrinin (8%), dihydrocitrinone (12%) and ochratoxin A (80%). Results of the control group followed the same pattern, but in general with a lower number of quantifiable results (<LOQ). Besides air samples, all the other environmental samples collected presented high and diverse contamination, and deoxynivalenol (DON), like in the biomonitoring results, was the most prominent mycotoxin. The results demonstrate that the occupational environment is adding and contributing to the workers’ total exposure to mycotoxins, particularly in the case of DON. This was confirmed by the biomonitoring data and the high contamination found in feed and litter samples. Furthermore, the followed multi-biomarker approach allowed to conclude that workers and general population are exposed to several mycotoxins simultaneously. Moreover, occupational exposure is probably described as being intermittent and with very high concentrations for short durations. This should be reflected in the risk assessment process.This research was funded by Instituto Politécnico de Lisboa, Lisbon, Portugal: Project “Bacterial Bioburden assessment in the context of occupational exposure and animal health of swine productions (IPL/2016/BBIOR_ESTeSL)” and also by FCT—Fundação para Ciência e Tecnologia: Project “EXPOsE – Establishing protocols to assess occupational exposure to microbiota in clinical settings (02/SAICT/2016 – Project nº 23222)”.MDPIRepositório Científico do Instituto Nacional de SaúdeViegas, S.Assunção, R.Martins, CarlaNunes, CarlaOsteresch, BerndTwaruzek, MagdalenaKosicki, RobertGrajewski, JanRibeiro, EdnaViegas, C.2020-04-28T21:52:45Z2019-02-012019-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6545engToxins (Basel). 2019 Feb 1;11(2):78. doi: 10.3390/toxins110200782072-665110.3390/toxins11020078info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:26Zoai:repositorio.insa.pt:10400.18/6545Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:07.601891Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Occupational Exposure to Mycotoxins in Swine Production: Environmental and Biological Monitoring Approaches
title Occupational Exposure to Mycotoxins in Swine Production: Environmental and Biological Monitoring Approaches
spellingShingle Occupational Exposure to Mycotoxins in Swine Production: Environmental and Biological Monitoring Approaches
Viegas, S.
Micotoxins
Biomonitoring
Mycotoxins Mixture
Occupational Exposure
Swine Production
Micotoxinas
Segurança Alimentar
Toxicologia
Avaliação de Risco
Saúde Humana
title_short Occupational Exposure to Mycotoxins in Swine Production: Environmental and Biological Monitoring Approaches
title_full Occupational Exposure to Mycotoxins in Swine Production: Environmental and Biological Monitoring Approaches
title_fullStr Occupational Exposure to Mycotoxins in Swine Production: Environmental and Biological Monitoring Approaches
title_full_unstemmed Occupational Exposure to Mycotoxins in Swine Production: Environmental and Biological Monitoring Approaches
title_sort Occupational Exposure to Mycotoxins in Swine Production: Environmental and Biological Monitoring Approaches
author Viegas, S.
author_facet Viegas, S.
Assunção, R.
Martins, Carla
Nunes, Carla
Osteresch, Bernd
Twaruzek, Magdalena
Kosicki, Robert
Grajewski, Jan
Ribeiro, Edna
Viegas, C.
author_role author
author2 Assunção, R.
Martins, Carla
Nunes, Carla
Osteresch, Bernd
Twaruzek, Magdalena
Kosicki, Robert
Grajewski, Jan
Ribeiro, Edna
Viegas, C.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Viegas, S.
Assunção, R.
Martins, Carla
Nunes, Carla
Osteresch, Bernd
Twaruzek, Magdalena
Kosicki, Robert
Grajewski, Jan
Ribeiro, Edna
Viegas, C.
dc.subject.por.fl_str_mv Micotoxins
Biomonitoring
Mycotoxins Mixture
Occupational Exposure
Swine Production
Micotoxinas
Segurança Alimentar
Toxicologia
Avaliação de Risco
Saúde Humana
topic Micotoxins
Biomonitoring
Mycotoxins Mixture
Occupational Exposure
Swine Production
Micotoxinas
Segurança Alimentar
Toxicologia
Avaliação de Risco
Saúde Humana
description Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30717100/
publishDate 2019
dc.date.none.fl_str_mv 2019-02-01
2019-02-01T00:00:00Z
2020-04-28T21:52:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/6545
url http://hdl.handle.net/10400.18/6545
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Toxins (Basel). 2019 Feb 1;11(2):78. doi: 10.3390/toxins11020078
2072-6651
10.3390/toxins11020078
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132154305708032

Registros relacionados