IL-6 and TNF-α salivary levels according to the periodontal status in Portuguese pregnant women

Detalhes bibliográficos
Autor(a) principal: Machado, Vanessa
Data de Publicação: 2018
Outros Autores: Mesquita, Maria Fernanda, Bernardo, Maria Alexandra, Casal, Ester, Proença, Luís, Mendes, José João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/29165
Resumo: Background Periodontitis is associated with increased concentration of inflammatory markers and saliva has been proposed as a non-invasive diagnostic fluid in oral and systemic diseases. The levels of salivary biomarkers, such as cytokines, could potentially be used to distinguish periodontal healthy individuals from subjects with periodontal disease. The purpose of this study was to characterize the salivary levels of two inflammatory biomarkers associated with periodontitis, interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α), in order to assess whether these cytokines salivary levels could potentially be used to complement periodontitis pregnant women diagnose.
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spelling IL-6 and TNF-α salivary levels according to the periodontal status in Portuguese pregnant womenIL-6TNF-αPregnant WomanPeriodontal diseaseSalivary levelsBackground Periodontitis is associated with increased concentration of inflammatory markers and saliva has been proposed as a non-invasive diagnostic fluid in oral and systemic diseases. The levels of salivary biomarkers, such as cytokines, could potentially be used to distinguish periodontal healthy individuals from subjects with periodontal disease. The purpose of this study was to characterize the salivary levels of two inflammatory biomarkers associated with periodontitis, interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α), in order to assess whether these cytokines salivary levels could potentially be used to complement periodontitis pregnant women diagnose.Methods Forty-four pregnant women were distributed into three groups, according to their periodontal status: healthy, mild/moderate periodontitis and severe periodontitis. Unstimulated saliva was collected and analysis of TNF-α and IL-6 salivary levels were performed with Immulite®.Results Women with periodontitis exhibited significantly higher levels (p = 0.001) of salivary IL-6 and TNF-α compared with the healthy group: 25.1 (±11.2) pg/mL vs. 16.3 (±5.0) pg/mL and 29.7 (±17.2) pg/mL vs. 16.2 (±7.6) pg/mL, approximately 1.5 and 1.8 times more, respectively. Additionally, cytokines were significantly increased (p < 0.05) in severe periodontitis compared to periodontal healthy pregnant women.Conclusions These results revealed that IL-6 and TNF-α salivary biomarkers provide high discriminatory capacity for distinguishing periodontal disease from periodontal health in pregnant women.Repositório ComumMachado, VanessaMesquita, Maria FernandaBernardo, Maria AlexandraCasal, EsterProença, LuísMendes, José João2019-07-08T15:26:14Z2018-05-01T00:00:00Z2018-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/29165engMachado V, Mesquita MF, Bernardo MA, Casal E, Proença L, Mendes JJ. 2018. IL-6 and TNF-α salivary levels according to the periodontal status in Portuguese pregnant women. PeerJ 6:e4710 https://doi.org/10.7717/peerj.47102167-835910.7717/peerj.4710info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:53:37Zoai:comum.rcaap.pt:10400.26/29165Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:09:27.475471Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv IL-6 and TNF-α salivary levels according to the periodontal status in Portuguese pregnant women
title IL-6 and TNF-α salivary levels according to the periodontal status in Portuguese pregnant women
spellingShingle IL-6 and TNF-α salivary levels according to the periodontal status in Portuguese pregnant women
Machado, Vanessa
IL-6
TNF-α
Pregnant Woman
Periodontal disease
Salivary levels
title_short IL-6 and TNF-α salivary levels according to the periodontal status in Portuguese pregnant women
title_full IL-6 and TNF-α salivary levels according to the periodontal status in Portuguese pregnant women
title_fullStr IL-6 and TNF-α salivary levels according to the periodontal status in Portuguese pregnant women
title_full_unstemmed IL-6 and TNF-α salivary levels according to the periodontal status in Portuguese pregnant women
title_sort IL-6 and TNF-α salivary levels according to the periodontal status in Portuguese pregnant women
author Machado, Vanessa
author_facet Machado, Vanessa
Mesquita, Maria Fernanda
Bernardo, Maria Alexandra
Casal, Ester
Proença, Luís
Mendes, José João
author_role author
author2 Mesquita, Maria Fernanda
Bernardo, Maria Alexandra
Casal, Ester
Proença, Luís
Mendes, José João
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Machado, Vanessa
Mesquita, Maria Fernanda
Bernardo, Maria Alexandra
Casal, Ester
Proença, Luís
Mendes, José João
dc.subject.por.fl_str_mv IL-6
TNF-α
Pregnant Woman
Periodontal disease
Salivary levels
topic IL-6
TNF-α
Pregnant Woman
Periodontal disease
Salivary levels
description Background Periodontitis is associated with increased concentration of inflammatory markers and saliva has been proposed as a non-invasive diagnostic fluid in oral and systemic diseases. The levels of salivary biomarkers, such as cytokines, could potentially be used to distinguish periodontal healthy individuals from subjects with periodontal disease. The purpose of this study was to characterize the salivary levels of two inflammatory biomarkers associated with periodontitis, interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α), in order to assess whether these cytokines salivary levels could potentially be used to complement periodontitis pregnant women diagnose.
publishDate 2018
dc.date.none.fl_str_mv 2018-05-01T00:00:00Z
2018-05-01T00:00:00Z
2019-07-08T15:26:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/29165
url http://hdl.handle.net/10400.26/29165
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Machado V, Mesquita MF, Bernardo MA, Casal E, Proença L, Mendes JJ. 2018. IL-6 and TNF-α salivary levels according to the periodontal status in Portuguese pregnant women. PeerJ 6:e4710 https://doi.org/10.7717/peerj.4710
2167-8359
10.7717/peerj.4710
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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