Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians

Detalhes bibliográficos
Autor(a) principal: Menezes,Natascha Giovannetti de
Data de Publicação: 2008
Outros Autores: Colombo,Ana Paula Vieira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Oral Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242008000400007
Resumo: This study evaluated the frequency of the tumor necrosis factor-alpha (TNF-α) -308 G/A polymorphism in Brazilians with periodontal health (PH = 51), chronic periodontitis (CP = 74) and generalized aggressive periodontitis (GAgP = 38). Human DNA was obtained from mouthwash samples and TNF-α genotyping was performed by PCR and RFLP analyses. Differences in clinical and genetic parameters among groups were sought by Kruskal-Wallis, χ² and Fisher's exact tests. The allele -308G was detected in 91.7%, whereas the allele -308A was found in 35.4% of all subjects. No significant differences were observed in the frequency of these alleles (χ² = 2.610, p > 0.05) and the genotypes G/G, G/A, and A/A (χ² = 2.547, p = 0.636) among groups. The data suggest that the TNF-α -308 G/A polymorphism is not associated with periodontitis in this Brazilian population.
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spelling Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in BraziliansTNF-alphaPeriodontal diseasesGenetic polymorphismPCRThis study evaluated the frequency of the tumor necrosis factor-alpha (TNF-α) -308 G/A polymorphism in Brazilians with periodontal health (PH = 51), chronic periodontitis (CP = 74) and generalized aggressive periodontitis (GAgP = 38). Human DNA was obtained from mouthwash samples and TNF-α genotyping was performed by PCR and RFLP analyses. Differences in clinical and genetic parameters among groups were sought by Kruskal-Wallis, χ² and Fisher's exact tests. The allele -308G was detected in 91.7%, whereas the allele -308A was found in 35.4% of all subjects. No significant differences were observed in the frequency of these alleles (χ² = 2.610, p > 0.05) and the genotypes G/G, G/A, and A/A (χ² = 2.547, p = 0.636) among groups. The data suggest that the TNF-α -308 G/A polymorphism is not associated with periodontitis in this Brazilian population.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242008000400007Brazilian Oral Research v.22 n.4 2008reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/S1806-83242008000400007info:eu-repo/semantics/openAccessMenezes,Natascha Giovannetti deColombo,Ana Paula Vieiraeng2009-10-20T00:00:00Zoai:scielo:S1806-83242008000400007Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2009-10-20T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false
dc.title.none.fl_str_mv Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians
title Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians
spellingShingle Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians
Menezes,Natascha Giovannetti de
TNF-alpha
Periodontal diseases
Genetic polymorphism
PCR
title_short Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians
title_full Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians
title_fullStr Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians
title_full_unstemmed Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians
title_sort Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians
author Menezes,Natascha Giovannetti de
author_facet Menezes,Natascha Giovannetti de
Colombo,Ana Paula Vieira
author_role author
author2 Colombo,Ana Paula Vieira
author2_role author
dc.contributor.author.fl_str_mv Menezes,Natascha Giovannetti de
Colombo,Ana Paula Vieira
dc.subject.por.fl_str_mv TNF-alpha
Periodontal diseases
Genetic polymorphism
PCR
topic TNF-alpha
Periodontal diseases
Genetic polymorphism
PCR
description This study evaluated the frequency of the tumor necrosis factor-alpha (TNF-α) -308 G/A polymorphism in Brazilians with periodontal health (PH = 51), chronic periodontitis (CP = 74) and generalized aggressive periodontitis (GAgP = 38). Human DNA was obtained from mouthwash samples and TNF-α genotyping was performed by PCR and RFLP analyses. Differences in clinical and genetic parameters among groups were sought by Kruskal-Wallis, χ² and Fisher's exact tests. The allele -308G was detected in 91.7%, whereas the allele -308A was found in 35.4% of all subjects. No significant differences were observed in the frequency of these alleles (χ² = 2.610, p > 0.05) and the genotypes G/G, G/A, and A/A (χ² = 2.547, p = 0.636) among groups. The data suggest that the TNF-α -308 G/A polymorphism is not associated with periodontitis in this Brazilian population.
publishDate 2008
dc.date.none.fl_str_mv 2008-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242008000400007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242008000400007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1806-83242008000400007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
dc.source.none.fl_str_mv Brazilian Oral Research v.22 n.4 2008
reponame:Brazilian Oral Research
instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
instacron:SBPQO
instname_str Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
instacron_str SBPQO
institution SBPQO
reponame_str Brazilian Oral Research
collection Brazilian Oral Research
repository.name.fl_str_mv Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
repository.mail.fl_str_mv pob@edu.usp.br||bor@sbpqo.org.br
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