Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242008000400007 |
Resumo: | This study evaluated the frequency of the tumor necrosis factor-alpha (TNF-α) -308 G/A polymorphism in Brazilians with periodontal health (PH = 51), chronic periodontitis (CP = 74) and generalized aggressive periodontitis (GAgP = 38). Human DNA was obtained from mouthwash samples and TNF-α genotyping was performed by PCR and RFLP analyses. Differences in clinical and genetic parameters among groups were sought by Kruskal-Wallis, χ² and Fisher's exact tests. The allele -308G was detected in 91.7%, whereas the allele -308A was found in 35.4% of all subjects. No significant differences were observed in the frequency of these alleles (χ² = 2.610, p > 0.05) and the genotypes G/G, G/A, and A/A (χ² = 2.547, p = 0.636) among groups. The data suggest that the TNF-α -308 G/A polymorphism is not associated with periodontitis in this Brazilian population. |
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Brazilian Oral Research |
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Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in BraziliansTNF-alphaPeriodontal diseasesGenetic polymorphismPCRThis study evaluated the frequency of the tumor necrosis factor-alpha (TNF-α) -308 G/A polymorphism in Brazilians with periodontal health (PH = 51), chronic periodontitis (CP = 74) and generalized aggressive periodontitis (GAgP = 38). Human DNA was obtained from mouthwash samples and TNF-α genotyping was performed by PCR and RFLP analyses. Differences in clinical and genetic parameters among groups were sought by Kruskal-Wallis, χ² and Fisher's exact tests. The allele -308G was detected in 91.7%, whereas the allele -308A was found in 35.4% of all subjects. No significant differences were observed in the frequency of these alleles (χ² = 2.610, p > 0.05) and the genotypes G/G, G/A, and A/A (χ² = 2.547, p = 0.636) among groups. The data suggest that the TNF-α -308 G/A polymorphism is not associated with periodontitis in this Brazilian population.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242008000400007Brazilian Oral Research v.22 n.4 2008reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/S1806-83242008000400007info:eu-repo/semantics/openAccessMenezes,Natascha Giovannetti deColombo,Ana Paula Vieiraeng2009-10-20T00:00:00Zoai:scielo:S1806-83242008000400007Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2009-10-20T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians |
title |
Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians |
spellingShingle |
Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians Menezes,Natascha Giovannetti de TNF-alpha Periodontal diseases Genetic polymorphism PCR |
title_short |
Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians |
title_full |
Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians |
title_fullStr |
Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians |
title_full_unstemmed |
Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians |
title_sort |
Lack of association between the TNF-α -308 (G/A) genetic polymorphism and periodontal disease in Brazilians |
author |
Menezes,Natascha Giovannetti de |
author_facet |
Menezes,Natascha Giovannetti de Colombo,Ana Paula Vieira |
author_role |
author |
author2 |
Colombo,Ana Paula Vieira |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Menezes,Natascha Giovannetti de Colombo,Ana Paula Vieira |
dc.subject.por.fl_str_mv |
TNF-alpha Periodontal diseases Genetic polymorphism PCR |
topic |
TNF-alpha Periodontal diseases Genetic polymorphism PCR |
description |
This study evaluated the frequency of the tumor necrosis factor-alpha (TNF-α) -308 G/A polymorphism in Brazilians with periodontal health (PH = 51), chronic periodontitis (CP = 74) and generalized aggressive periodontitis (GAgP = 38). Human DNA was obtained from mouthwash samples and TNF-α genotyping was performed by PCR and RFLP analyses. Differences in clinical and genetic parameters among groups were sought by Kruskal-Wallis, χ² and Fisher's exact tests. The allele -308G was detected in 91.7%, whereas the allele -308A was found in 35.4% of all subjects. No significant differences were observed in the frequency of these alleles (χ² = 2.610, p > 0.05) and the genotypes G/G, G/A, and A/A (χ² = 2.547, p = 0.636) among groups. The data suggest that the TNF-α -308 G/A polymorphism is not associated with periodontitis in this Brazilian population. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242008000400007 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242008000400007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1806-83242008000400007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.22 n.4 2008 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
_version_ |
1750318321303027712 |