Sarcoidosis Presenting as Cranial Multinevritis

Detalhes bibliográficos
Autor(a) principal: Xavier Pires, Sara
Data de Publicação: 2021
Outros Autores: Pinheiro, Maria Guiomar, Serpa Pinto, Luísa, Sequeira, Teresa, Marinho, Antonio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.16/2858
Resumo: A 29-year-old woman presented to the emergency department with red eyes and hypoacusia since the previous weeks associated with a sudden right facial palsy. Ophthalmologic examination revealed bilateral uveitis and lumbar puncture was compatible with aseptic meningitis. Thoracic computed tomography scan showed pulmonary nodules and mediastinal and hilar lymphadenopathy. Bronchoalveolar lavage revealed a CD4/CD8 ratio of 8, and lymph node biopsy confirmed non-caseating granulomas. The diagnosis of sarcoidosis with ocular, pulmonary, and neurologic involvement was made. Due to sarcoidosis severity at presentation, the patient was started on systemic steroids and methotrexate with improvement. Sarcoidosis involvement of the central nervous system is a rare condition (5-10%) but can be the first manifestation of the disease. Its presentation can be heterogeneous; therefore, symptoms are frequently devalued by patients and physicians, leading to a late diagnosis and permanent damage. Clinicians' awareness is crucial to early diagnosis and treatment.
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spelling Sarcoidosis Presenting as Cranial MultinevritisAutoimmunity; Cranial nerves palsySarcoidosisUveitisA 29-year-old woman presented to the emergency department with red eyes and hypoacusia since the previous weeks associated with a sudden right facial palsy. Ophthalmologic examination revealed bilateral uveitis and lumbar puncture was compatible with aseptic meningitis. Thoracic computed tomography scan showed pulmonary nodules and mediastinal and hilar lymphadenopathy. Bronchoalveolar lavage revealed a CD4/CD8 ratio of 8, and lymph node biopsy confirmed non-caseating granulomas. The diagnosis of sarcoidosis with ocular, pulmonary, and neurologic involvement was made. Due to sarcoidosis severity at presentation, the patient was started on systemic steroids and methotrexate with improvement. Sarcoidosis involvement of the central nervous system is a rare condition (5-10%) but can be the first manifestation of the disease. Its presentation can be heterogeneous; therefore, symptoms are frequently devalued by patients and physicians, leading to a late diagnosis and permanent damage. Clinicians' awareness is crucial to early diagnosis and treatment.Elmer PressRepositório Científico do Centro Hospitalar Universitário de Santo AntónioXavier Pires, SaraPinheiro, Maria GuiomarSerpa Pinto, LuísaSequeira, TeresaMarinho, Antonio2023-10-30T12:54:07Z2021-032021-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2858engXavier Pires S, Pinheiro G, Serpa Pinto L, Sequeira T, Marinho A. Sarcoidosis Presenting as Cranial Multinevritis. J Med Cases. 2021;12(3):112-114. doi:10.14740/jmc36351923-415510.14740/jmc3635info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-02T05:59:33Zoai:repositorio.chporto.pt:10400.16/2858Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:26:27.872162Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Sarcoidosis Presenting as Cranial Multinevritis
title Sarcoidosis Presenting as Cranial Multinevritis
spellingShingle Sarcoidosis Presenting as Cranial Multinevritis
Xavier Pires, Sara
Autoimmunity
; Cranial nerves palsy
Sarcoidosis
Uveitis
title_short Sarcoidosis Presenting as Cranial Multinevritis
title_full Sarcoidosis Presenting as Cranial Multinevritis
title_fullStr Sarcoidosis Presenting as Cranial Multinevritis
title_full_unstemmed Sarcoidosis Presenting as Cranial Multinevritis
title_sort Sarcoidosis Presenting as Cranial Multinevritis
author Xavier Pires, Sara
author_facet Xavier Pires, Sara
Pinheiro, Maria Guiomar
Serpa Pinto, Luísa
Sequeira, Teresa
Marinho, Antonio
author_role author
author2 Pinheiro, Maria Guiomar
Serpa Pinto, Luísa
Sequeira, Teresa
Marinho, Antonio
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Centro Hospitalar Universitário de Santo António
dc.contributor.author.fl_str_mv Xavier Pires, Sara
Pinheiro, Maria Guiomar
Serpa Pinto, Luísa
Sequeira, Teresa
Marinho, Antonio
dc.subject.por.fl_str_mv Autoimmunity
; Cranial nerves palsy
Sarcoidosis
Uveitis
topic Autoimmunity
; Cranial nerves palsy
Sarcoidosis
Uveitis
description A 29-year-old woman presented to the emergency department with red eyes and hypoacusia since the previous weeks associated with a sudden right facial palsy. Ophthalmologic examination revealed bilateral uveitis and lumbar puncture was compatible with aseptic meningitis. Thoracic computed tomography scan showed pulmonary nodules and mediastinal and hilar lymphadenopathy. Bronchoalveolar lavage revealed a CD4/CD8 ratio of 8, and lymph node biopsy confirmed non-caseating granulomas. The diagnosis of sarcoidosis with ocular, pulmonary, and neurologic involvement was made. Due to sarcoidosis severity at presentation, the patient was started on systemic steroids and methotrexate with improvement. Sarcoidosis involvement of the central nervous system is a rare condition (5-10%) but can be the first manifestation of the disease. Its presentation can be heterogeneous; therefore, symptoms are frequently devalued by patients and physicians, leading to a late diagnosis and permanent damage. Clinicians' awareness is crucial to early diagnosis and treatment.
publishDate 2021
dc.date.none.fl_str_mv 2021-03
2021-03-01T00:00:00Z
2023-10-30T12:54:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.16/2858
url http://hdl.handle.net/10400.16/2858
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Xavier Pires S, Pinheiro G, Serpa Pinto L, Sequeira T, Marinho A. Sarcoidosis Presenting as Cranial Multinevritis. J Med Cases. 2021;12(3):112-114. doi:10.14740/jmc3635
1923-4155
10.14740/jmc3635
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elmer Press
publisher.none.fl_str_mv Elmer Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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