Sarcoidosis Presenting as Cranial Multinevritis
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/2858 |
Resumo: | A 29-year-old woman presented to the emergency department with red eyes and hypoacusia since the previous weeks associated with a sudden right facial palsy. Ophthalmologic examination revealed bilateral uveitis and lumbar puncture was compatible with aseptic meningitis. Thoracic computed tomography scan showed pulmonary nodules and mediastinal and hilar lymphadenopathy. Bronchoalveolar lavage revealed a CD4/CD8 ratio of 8, and lymph node biopsy confirmed non-caseating granulomas. The diagnosis of sarcoidosis with ocular, pulmonary, and neurologic involvement was made. Due to sarcoidosis severity at presentation, the patient was started on systemic steroids and methotrexate with improvement. Sarcoidosis involvement of the central nervous system is a rare condition (5-10%) but can be the first manifestation of the disease. Its presentation can be heterogeneous; therefore, symptoms are frequently devalued by patients and physicians, leading to a late diagnosis and permanent damage. Clinicians' awareness is crucial to early diagnosis and treatment. |
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Sarcoidosis Presenting as Cranial MultinevritisAutoimmunity; Cranial nerves palsySarcoidosisUveitisA 29-year-old woman presented to the emergency department with red eyes and hypoacusia since the previous weeks associated with a sudden right facial palsy. Ophthalmologic examination revealed bilateral uveitis and lumbar puncture was compatible with aseptic meningitis. Thoracic computed tomography scan showed pulmonary nodules and mediastinal and hilar lymphadenopathy. Bronchoalveolar lavage revealed a CD4/CD8 ratio of 8, and lymph node biopsy confirmed non-caseating granulomas. The diagnosis of sarcoidosis with ocular, pulmonary, and neurologic involvement was made. Due to sarcoidosis severity at presentation, the patient was started on systemic steroids and methotrexate with improvement. Sarcoidosis involvement of the central nervous system is a rare condition (5-10%) but can be the first manifestation of the disease. Its presentation can be heterogeneous; therefore, symptoms are frequently devalued by patients and physicians, leading to a late diagnosis and permanent damage. Clinicians' awareness is crucial to early diagnosis and treatment.Elmer PressRepositório Científico do Centro Hospitalar Universitário de Santo AntónioXavier Pires, SaraPinheiro, Maria GuiomarSerpa Pinto, LuísaSequeira, TeresaMarinho, Antonio2023-10-30T12:54:07Z2021-032021-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2858engXavier Pires S, Pinheiro G, Serpa Pinto L, Sequeira T, Marinho A. Sarcoidosis Presenting as Cranial Multinevritis. J Med Cases. 2021;12(3):112-114. doi:10.14740/jmc36351923-415510.14740/jmc3635info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-02T05:59:33Zoai:repositorio.chporto.pt:10400.16/2858Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:26:27.872162Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Sarcoidosis Presenting as Cranial Multinevritis |
title |
Sarcoidosis Presenting as Cranial Multinevritis |
spellingShingle |
Sarcoidosis Presenting as Cranial Multinevritis Xavier Pires, Sara Autoimmunity ; Cranial nerves palsy Sarcoidosis Uveitis |
title_short |
Sarcoidosis Presenting as Cranial Multinevritis |
title_full |
Sarcoidosis Presenting as Cranial Multinevritis |
title_fullStr |
Sarcoidosis Presenting as Cranial Multinevritis |
title_full_unstemmed |
Sarcoidosis Presenting as Cranial Multinevritis |
title_sort |
Sarcoidosis Presenting as Cranial Multinevritis |
author |
Xavier Pires, Sara |
author_facet |
Xavier Pires, Sara Pinheiro, Maria Guiomar Serpa Pinto, Luísa Sequeira, Teresa Marinho, Antonio |
author_role |
author |
author2 |
Pinheiro, Maria Guiomar Serpa Pinto, Luísa Sequeira, Teresa Marinho, Antonio |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Xavier Pires, Sara Pinheiro, Maria Guiomar Serpa Pinto, Luísa Sequeira, Teresa Marinho, Antonio |
dc.subject.por.fl_str_mv |
Autoimmunity ; Cranial nerves palsy Sarcoidosis Uveitis |
topic |
Autoimmunity ; Cranial nerves palsy Sarcoidosis Uveitis |
description |
A 29-year-old woman presented to the emergency department with red eyes and hypoacusia since the previous weeks associated with a sudden right facial palsy. Ophthalmologic examination revealed bilateral uveitis and lumbar puncture was compatible with aseptic meningitis. Thoracic computed tomography scan showed pulmonary nodules and mediastinal and hilar lymphadenopathy. Bronchoalveolar lavage revealed a CD4/CD8 ratio of 8, and lymph node biopsy confirmed non-caseating granulomas. The diagnosis of sarcoidosis with ocular, pulmonary, and neurologic involvement was made. Due to sarcoidosis severity at presentation, the patient was started on systemic steroids and methotrexate with improvement. Sarcoidosis involvement of the central nervous system is a rare condition (5-10%) but can be the first manifestation of the disease. Its presentation can be heterogeneous; therefore, symptoms are frequently devalued by patients and physicians, leading to a late diagnosis and permanent damage. Clinicians' awareness is crucial to early diagnosis and treatment. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03 2021-03-01T00:00:00Z 2023-10-30T12:54:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/2858 |
url |
http://hdl.handle.net/10400.16/2858 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Xavier Pires S, Pinheiro G, Serpa Pinto L, Sequeira T, Marinho A. Sarcoidosis Presenting as Cranial Multinevritis. J Med Cases. 2021;12(3):112-114. doi:10.14740/jmc3635 1923-4155 10.14740/jmc3635 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elmer Press |
publisher.none.fl_str_mv |
Elmer Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134146143977472 |