Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance

Detalhes bibliográficos
Autor(a) principal: Cruz, Adriana
Data de Publicação: 2020
Outros Autores: Mota, Pedro, Ramos, Cristiano, Pires, Rita F, Mendes, Cindy, Silva, José P, Nunes, Sofia C, Bonifácio, Vasco D B, Serpa, Jacinta
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/92605
Resumo: The research was funded by iNOVA4Health—UID/Multi/04462/, a program financially supported by the Fundação para a Ciência e a Tecnologia—Ministério da Educação e Ciência (FCT-MCTES), through nationalfunds and co-funded by FEDER under the PT2020 Partnership Agreement. We also acknowledge funding from FCT-MCTES through the project DREAM—PTDC/MEC-ONC/29327/2017 and FAI2017 from IPOLFG internal funding.
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spelling Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine sulfoximine as a Tool to Tackle Ovarian Cancer ChemoresistanceSDG 3 - Good Health and Well-beingThe research was funded by iNOVA4Health—UID/Multi/04462/, a program financially supported by the Fundação para a Ciência e a Tecnologia—Ministério da Educação e Ciência (FCT-MCTES), through nationalfunds and co-funded by FEDER under the PT2020 Partnership Agreement. We also acknowledge funding from FCT-MCTES through the project DREAM—PTDC/MEC-ONC/29327/2017 and FAI2017 from IPOLFG internal funding.: Ovarian cancer is a highly lethal disease, mainly due to chemoresistance. Our previous studies on metabolic remodeling in ovarian cancer have supported that the reliance on glutathione (GSH) bioavailability is a main adaptive metabolic mechanism, also accounting for chemoresistance to conventional therapy based on platinum salts. In this study, we tested the effects of the in vitro inhibition of GSH synthesis on the restoration of ovarian cancer cells sensitivity to carboplatin. GSH synthesis was inhibited by exposing cells to l-buthionine sulfoximine (l-BSO), an inhibitor of -glutamylcysteine ligase (GCL). Given the systemic toxicity of l-BSO, we developed a new formulation using polyurea (PURE) dendrimers nanoparticles (l-BSO@PUREG4-FA2), targeting l-BSO delivery in a folate functionalized nanoparticle.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNCruz, AdrianaMota, PedroRamos, CristianoPires, Rita FMendes, CindySilva, José PNunes, Sofia CBonifácio, Vasco D BSerpa, Jacinta2020-02-12T03:06:51Z2020-02-032020-02-03T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/92605eng2076-3921PURE: 16776924https://doi.org/10.3390/antiox9020133info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:41:17Zoai:run.unl.pt:10362/92605Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:37:34.078097Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance
title Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance
spellingShingle Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance
Cruz, Adriana
SDG 3 - Good Health and Well-being
title_short Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance
title_full Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance
title_fullStr Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance
title_full_unstemmed Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance
title_sort Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance
author Cruz, Adriana
author_facet Cruz, Adriana
Mota, Pedro
Ramos, Cristiano
Pires, Rita F
Mendes, Cindy
Silva, José P
Nunes, Sofia C
Bonifácio, Vasco D B
Serpa, Jacinta
author_role author
author2 Mota, Pedro
Ramos, Cristiano
Pires, Rita F
Mendes, Cindy
Silva, José P
Nunes, Sofia C
Bonifácio, Vasco D B
Serpa, Jacinta
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Cruz, Adriana
Mota, Pedro
Ramos, Cristiano
Pires, Rita F
Mendes, Cindy
Silva, José P
Nunes, Sofia C
Bonifácio, Vasco D B
Serpa, Jacinta
dc.subject.por.fl_str_mv SDG 3 - Good Health and Well-being
topic SDG 3 - Good Health and Well-being
description The research was funded by iNOVA4Health—UID/Multi/04462/, a program financially supported by the Fundação para a Ciência e a Tecnologia—Ministério da Educação e Ciência (FCT-MCTES), through nationalfunds and co-funded by FEDER under the PT2020 Partnership Agreement. We also acknowledge funding from FCT-MCTES through the project DREAM—PTDC/MEC-ONC/29327/2017 and FAI2017 from IPOLFG internal funding.
publishDate 2020
dc.date.none.fl_str_mv 2020-02-12T03:06:51Z
2020-02-03
2020-02-03T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/92605
url http://hdl.handle.net/10362/92605
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2076-3921
PURE: 16776924
https://doi.org/10.3390/antiox9020133
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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