Twenty-year trajectories of cardio-metabolic factors among people with type 2 diabetes by dementia status in England
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/154065 |
Resumo: | Funding Information: The Department of Primary Care and Public Health at Imperial College London is grateful for support from the NW London NIHR Applied Research Collaboration and the Imperial NIHR Biomedical Research Centre. Funding Information: This research was supported by Grant No: 18/0005851 from Diabetes UK. The funders of the study had no role in study design, data collection, analysis, interpretation, report writing, or the decision to submit for publication. The views expressed in this publication are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. Publisher Copyright: © 2023, The Author(s). |
| id |
RCAP_2a392c48d71a95de5beb84a1296a47dd |
|---|---|
| oai_identifier_str |
oai:run.unl.pt:10362/154065 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository_id_str |
7160 |
| spelling |
Twenty-year trajectories of cardio-metabolic factors among people with type 2 diabetes by dementia status in Englanda retrospective cohort studyBlood pressureBody mass indexCardio-metabolic risk factorsCholesterolCohortDementiaGlucoseHaemoglobin A1cHigh-density lipoproteinLongitudinalLow-density lipoproteinPredictorsTrajectoriesType 2 diabetesVascular risk factorsEpidemiologySDG 3 - Good Health and Well-beingFunding Information: The Department of Primary Care and Public Health at Imperial College London is grateful for support from the NW London NIHR Applied Research Collaboration and the Imperial NIHR Biomedical Research Centre. Funding Information: This research was supported by Grant No: 18/0005851 from Diabetes UK. The funders of the study had no role in study design, data collection, analysis, interpretation, report writing, or the decision to submit for publication. The views expressed in this publication are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. Publisher Copyright: © 2023, The Author(s).To assess 20-year retrospective trajectories of cardio-metabolic factors preceding dementia diagnosis among people with type 2 diabetes (T2D). We identified 227,145 people with T2D aged > 42 years between 1999 and 2018. Annual mean levels of eight routinely measured cardio-metabolic factors were extracted from the Clinical Practice Research Datalink. Multivariable multilevel piecewise and non-piecewise growth curve models assessed retrospective trajectories of cardio-metabolic factors by dementia status from up to 19 years preceding dementia diagnosis (dementia) or last contact with healthcare (no dementia). 23,546 patients developed dementia; mean (SD) follow-up was 10.0 (5.8) years. In the dementia group, mean systolic blood pressure increased 16–19 years before dementia diagnosis compared with patients without dementia, but declined more steeply from 16 years before diagnosis, while diastolic blood pressure generally declined at similar rates. Mean body mass index followed a steeper non-linear decline from 11 years before diagnosis in the dementia group. Mean blood lipid levels (total cholesterol, LDL, HDL) and glycaemic measures (fasting plasma glucose and HbA1c) were generally higher in the dementia group compared with those without dementia and followed similar patterns of change. However, absolute group differences were small. Differences in levels of cardio-metabolic factors were observed up to two decades prior to dementia diagnosis. Our findings suggest that a long follow-up is crucial to minimise reverse causation arising from changes in cardio-metabolic factors during preclinical dementia. Future investigations which address associations between cardiometabolic factors and dementia should account for potential non-linear relationships and consider the timeframe when measurements are taken.Centro de Investigação em Saúde Pública (CISP/PHRC)Comprehensive Health Research Centre (CHRC) - Pólo ENSPEscola Nacional de Saúde Pública (ENSP)RUNLai, Heidi T.M.Chang, KiaraSharabiani, Mansour T.A.Valabhji, JonathanGregg, Edward W.Middleton, LefkosMajeed, AzeemPearson-Stuttard, JonathanMillett, ChristopherBottle, AlexVamos, Eszter P.2023-06-16T22:20:31Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/154065eng0393-2990PURE: 63856168https://doi.org/10.1007/s10654-023-00977-7info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:36:34Zoai:run.unl.pt:10362/154065Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:29.822818Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Twenty-year trajectories of cardio-metabolic factors among people with type 2 diabetes by dementia status in England a retrospective cohort study |
| title |
Twenty-year trajectories of cardio-metabolic factors among people with type 2 diabetes by dementia status in England |
| spellingShingle |
Twenty-year trajectories of cardio-metabolic factors among people with type 2 diabetes by dementia status in England Lai, Heidi T.M. Blood pressure Body mass index Cardio-metabolic risk factors Cholesterol Cohort Dementia Glucose Haemoglobin A1c High-density lipoprotein Longitudinal Low-density lipoprotein Predictors Trajectories Type 2 diabetes Vascular risk factors Epidemiology SDG 3 - Good Health and Well-being |
| title_short |
Twenty-year trajectories of cardio-metabolic factors among people with type 2 diabetes by dementia status in England |
| title_full |
Twenty-year trajectories of cardio-metabolic factors among people with type 2 diabetes by dementia status in England |
| title_fullStr |
Twenty-year trajectories of cardio-metabolic factors among people with type 2 diabetes by dementia status in England |
| title_full_unstemmed |
Twenty-year trajectories of cardio-metabolic factors among people with type 2 diabetes by dementia status in England |
| title_sort |
Twenty-year trajectories of cardio-metabolic factors among people with type 2 diabetes by dementia status in England |
| author |
Lai, Heidi T.M. |
| author_facet |
Lai, Heidi T.M. Chang, Kiara Sharabiani, Mansour T.A. Valabhji, Jonathan Gregg, Edward W. Middleton, Lefkos Majeed, Azeem Pearson-Stuttard, Jonathan Millett, Christopher Bottle, Alex Vamos, Eszter P. |
| author_role |
author |
| author2 |
Chang, Kiara Sharabiani, Mansour T.A. Valabhji, Jonathan Gregg, Edward W. Middleton, Lefkos Majeed, Azeem Pearson-Stuttard, Jonathan Millett, Christopher Bottle, Alex Vamos, Eszter P. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centro de Investigação em Saúde Pública (CISP/PHRC) Comprehensive Health Research Centre (CHRC) - Pólo ENSP Escola Nacional de Saúde Pública (ENSP) RUN |
| dc.contributor.author.fl_str_mv |
Lai, Heidi T.M. Chang, Kiara Sharabiani, Mansour T.A. Valabhji, Jonathan Gregg, Edward W. Middleton, Lefkos Majeed, Azeem Pearson-Stuttard, Jonathan Millett, Christopher Bottle, Alex Vamos, Eszter P. |
| dc.subject.por.fl_str_mv |
Blood pressure Body mass index Cardio-metabolic risk factors Cholesterol Cohort Dementia Glucose Haemoglobin A1c High-density lipoprotein Longitudinal Low-density lipoprotein Predictors Trajectories Type 2 diabetes Vascular risk factors Epidemiology SDG 3 - Good Health and Well-being |
| topic |
Blood pressure Body mass index Cardio-metabolic risk factors Cholesterol Cohort Dementia Glucose Haemoglobin A1c High-density lipoprotein Longitudinal Low-density lipoprotein Predictors Trajectories Type 2 diabetes Vascular risk factors Epidemiology SDG 3 - Good Health and Well-being |
| description |
Funding Information: The Department of Primary Care and Public Health at Imperial College London is grateful for support from the NW London NIHR Applied Research Collaboration and the Imperial NIHR Biomedical Research Centre. Funding Information: This research was supported by Grant No: 18/0005851 from Diabetes UK. The funders of the study had no role in study design, data collection, analysis, interpretation, report writing, or the decision to submit for publication. The views expressed in this publication are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. Publisher Copyright: © 2023, The Author(s). |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-06-16T22:20:31Z 2023 2023-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/154065 |
| url |
http://hdl.handle.net/10362/154065 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0393-2990 PURE: 63856168 https://doi.org/10.1007/s10654-023-00977-7 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
|
| _version_ |
1799138142143381504 |