Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins

Detalhes bibliográficos
Autor(a) principal: Azevedo, Raquel
Data de Publicação: 2019
Outros Autores: Mendes, António M., Prudêncio, Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50287
Resumo: © The Author(s) 2019. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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spelling Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectinsAvermectinsIvermectinMalaria transmissionPlasmodium© The Author(s) 2019. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Background: The transmissible forms of Plasmodium parasites result from a process of sporogony that takes place inside their obligatory mosquito vector and culminates in the formation of mammalian-infective parasite forms. Ivermectin is a member of the avermectin family of endectocides, which has been proposed to inhibit malaria transmission due its insecticidal effect. However, it remains unclear whether ivermectin also exerts a direct action on the parasite's blood and transmission stages. Methods: We employed a rodent model of infection to assess the impact of ivermectin treatment on P. berghei asexual and sexual blood forms in vivo. We then made use of a newly established luminescence-based methodology to evaluate the activity of ivermectin and other avermectins against the sporogonic stages of P. berghei parasites in vitro independent of their role on mosquito physiology. Results: Our results show that whereas ivermectin does not affect the parasite's parasitemia, gametocytemia or exflagellation in the mammalian host, several members of the avermectin family of compounds exert a strong inhibitory effect on the generation and development of P. berghei oocysts. Conclusions: Our results shed light on the action of avermectins against Plasmodium transmission stages and highlight the potential of these compounds to help prevent the spread of malaria.This work was carried out with the support of grants PTDC-BBB-BMD-2695-2014 and 02/SAICT/2017/29550 from Fundação para a Ciência e Tecnologia, Portugal (FCT) to AMM and MP, respectively, and by FCT grant UID/BIM/50005/2019 (Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through Fundos do Orçamento de Estado). RA was supported by FCT’s fellowship BD/131334/2017, AMM was supported by FCT’s fellowship SFRH/BPD/80693/2011, and MP was supported by FCT’s Investigador FCT 2013 and CEEC 2018 fellowships.Springer NatureRepositório da Universidade de LisboaAzevedo, RaquelMendes, António M.Prudêncio, Miguel2021-12-06T15:12:26Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50287engParasit Vectors. 2019 Nov 21;12(1):54910.1186/s13071-019-3805-01756-3305info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:24Zoai:repositorio.ul.pt:10451/50287Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:47.104637Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins
title Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins
spellingShingle Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins
Azevedo, Raquel
Avermectins
Ivermectin
Malaria transmission
Plasmodium
title_short Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins
title_full Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins
title_fullStr Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins
title_full_unstemmed Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins
title_sort Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins
author Azevedo, Raquel
author_facet Azevedo, Raquel
Mendes, António M.
Prudêncio, Miguel
author_role author
author2 Mendes, António M.
Prudêncio, Miguel
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Azevedo, Raquel
Mendes, António M.
Prudêncio, Miguel
dc.subject.por.fl_str_mv Avermectins
Ivermectin
Malaria transmission
Plasmodium
topic Avermectins
Ivermectin
Malaria transmission
Plasmodium
description © The Author(s) 2019. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2021-12-06T15:12:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50287
url http://hdl.handle.net/10451/50287
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Parasit Vectors. 2019 Nov 21;12(1):549
10.1186/s13071-019-3805-0
1756-3305
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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