Inhibition of Plasmodium liver infection by Ivermectin

Detalhes bibliográficos
Autor(a) principal: Mendes, António M.
Data de Publicação: 2017
Outros Autores: Albuquerque, Inês S., Machado, Marta, Pissarra, Joana, Meireles, Patricia, Prudêncio, Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49163
Resumo: Copyright © 2017 Mendes et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
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spelling Inhibition of Plasmodium liver infection by IvermectinPlasmodiumAvermectinsIvermectinLiver stageMalariaCopyright © 2017 Mendes et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.Avermectins are powerful endectocides with an established potential to reduce the incidence of vector-borne diseases. Here, we show that several avermectins inhibit the hepatic stage of Plasmodium infection in vitro Notably, ivermectin potently inhibits liver infection in vivo by impairing parasite development inside hepatocytes. This impairment has a clear impact on the ensuing blood stage parasitemia, reducing disease severity and enhancing host survival. Ivermectin has been proposed as a tool to control malaria transmission because of its effects on the mosquito vector. Our study extends the effect of ivermectin to the early stages of mammalian host infection and supports the inclusion of this multipurpose drug in malaria control strategies.A.M.M., P.M., and M.P. acknowledge the Fundação para a Ciência e Tecnologia, Portugal, for grants SFRH/BPD/80693/2011, SFRH/BD/71098/2010, and Investigador FCT (2013), respectively. This work was supported by Fundação para a Ciência e Tecnologia (FCT, Portugal) grant PTDC/SAU-MIC/117060/2010.ASM JournalsRepositório da Universidade de LisboaMendes, António M.Albuquerque, Inês S.Machado, MartaPissarra, JoanaMeireles, PatriciaPrudêncio, Miguel2021-07-27T13:24:17Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49163engAntimicrob Agents Chemother. 2017 Jan 24;61(2):e02005-16.0066-480410.1128/AAC.02005-161098-6596info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:52:35Zoai:repositorio.ul.pt:10451/49163Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:43.655039Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Inhibition of Plasmodium liver infection by Ivermectin
title Inhibition of Plasmodium liver infection by Ivermectin
spellingShingle Inhibition of Plasmodium liver infection by Ivermectin
Mendes, António M.
Plasmodium
Avermectins
Ivermectin
Liver stage
Malaria
title_short Inhibition of Plasmodium liver infection by Ivermectin
title_full Inhibition of Plasmodium liver infection by Ivermectin
title_fullStr Inhibition of Plasmodium liver infection by Ivermectin
title_full_unstemmed Inhibition of Plasmodium liver infection by Ivermectin
title_sort Inhibition of Plasmodium liver infection by Ivermectin
author Mendes, António M.
author_facet Mendes, António M.
Albuquerque, Inês S.
Machado, Marta
Pissarra, Joana
Meireles, Patricia
Prudêncio, Miguel
author_role author
author2 Albuquerque, Inês S.
Machado, Marta
Pissarra, Joana
Meireles, Patricia
Prudêncio, Miguel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Mendes, António M.
Albuquerque, Inês S.
Machado, Marta
Pissarra, Joana
Meireles, Patricia
Prudêncio, Miguel
dc.subject.por.fl_str_mv Plasmodium
Avermectins
Ivermectin
Liver stage
Malaria
topic Plasmodium
Avermectins
Ivermectin
Liver stage
Malaria
description Copyright © 2017 Mendes et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2021-07-27T13:24:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49163
url http://hdl.handle.net/10451/49163
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Antimicrob Agents Chemother. 2017 Jan 24;61(2):e02005-16.
0066-4804
10.1128/AAC.02005-16
1098-6596
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ASM Journals
publisher.none.fl_str_mv ASM Journals
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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