Patência do canal arterial no recém-nascido de pré-termo: experiência de um hospital terciário
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/128681 |
Resumo: | Introduction: Patent ductus arteriosus (PDA) in preterm newborns (PTNB) has been associated with increased mortality and co-morbidities. This study aimed to characterize the population of preterm infants diagnosed with PDA and to identify predictive factors of response to medical treatment of PDA. Methods: An eight-year retrospective observational study was carried out, which included all PTNBs with gestational age between 24 and 32 weeks diagnosed with PDA, admitted to the HSJ Obstetrics Service. Univariate comparative analysis was performed, and models for predicting the effectiveness of PDA treatment with ibuprofen were explored by multivariate logistic regression analysis. Results: Were included in the study 114 cases and 33 were excluded, with a final sample of 81 PTNB with PDA. The univariable analysis revealed significant differences in the closure efficacy by medical treatment with ibuprofen in several variables, and a multivariate logistic regression model was obtained (discriminative capacity 72.2%, sensitivity 98.1%, specificity 57.1%), considering the effect of gestational age, type of delivery, need for diuretics treatment and platelet transfusion. Conclusion: This study allowed to characterize the population of preterm infants diagnosed with PDA and the identification of a predictive model that can aid to predict the effectiveness to the medical treatment and thus contribute to optimize the medical approach to the non-responders. |
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Patência do canal arterial no recém-nascido de pré-termo: experiência de um hospital terciárioMedicina clínicaClinical medicineIntroduction: Patent ductus arteriosus (PDA) in preterm newborns (PTNB) has been associated with increased mortality and co-morbidities. This study aimed to characterize the population of preterm infants diagnosed with PDA and to identify predictive factors of response to medical treatment of PDA. Methods: An eight-year retrospective observational study was carried out, which included all PTNBs with gestational age between 24 and 32 weeks diagnosed with PDA, admitted to the HSJ Obstetrics Service. Univariate comparative analysis was performed, and models for predicting the effectiveness of PDA treatment with ibuprofen were explored by multivariate logistic regression analysis. Results: Were included in the study 114 cases and 33 were excluded, with a final sample of 81 PTNB with PDA. The univariable analysis revealed significant differences in the closure efficacy by medical treatment with ibuprofen in several variables, and a multivariate logistic regression model was obtained (discriminative capacity 72.2%, sensitivity 98.1%, specificity 57.1%), considering the effect of gestational age, type of delivery, need for diuretics treatment and platelet transfusion. Conclusion: This study allowed to characterize the population of preterm infants diagnosed with PDA and the identification of a predictive model that can aid to predict the effectiveness to the medical treatment and thus contribute to optimize the medical approach to the non-responders.2020-05-122020-05-12T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://hdl.handle.net/10216/128681TID:202613860porJoana Cristina Gouveia Santosinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:04:16Zoai:repositorio-aberto.up.pt:10216/128681Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:53:58.318433Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Patência do canal arterial no recém-nascido de pré-termo: experiência de um hospital terciário |
title |
Patência do canal arterial no recém-nascido de pré-termo: experiência de um hospital terciário |
spellingShingle |
Patência do canal arterial no recém-nascido de pré-termo: experiência de um hospital terciário Joana Cristina Gouveia Santos Medicina clínica Clinical medicine |
title_short |
Patência do canal arterial no recém-nascido de pré-termo: experiência de um hospital terciário |
title_full |
Patência do canal arterial no recém-nascido de pré-termo: experiência de um hospital terciário |
title_fullStr |
Patência do canal arterial no recém-nascido de pré-termo: experiência de um hospital terciário |
title_full_unstemmed |
Patência do canal arterial no recém-nascido de pré-termo: experiência de um hospital terciário |
title_sort |
Patência do canal arterial no recém-nascido de pré-termo: experiência de um hospital terciário |
author |
Joana Cristina Gouveia Santos |
author_facet |
Joana Cristina Gouveia Santos |
author_role |
author |
dc.contributor.author.fl_str_mv |
Joana Cristina Gouveia Santos |
dc.subject.por.fl_str_mv |
Medicina clínica Clinical medicine |
topic |
Medicina clínica Clinical medicine |
description |
Introduction: Patent ductus arteriosus (PDA) in preterm newborns (PTNB) has been associated with increased mortality and co-morbidities. This study aimed to characterize the population of preterm infants diagnosed with PDA and to identify predictive factors of response to medical treatment of PDA. Methods: An eight-year retrospective observational study was carried out, which included all PTNBs with gestational age between 24 and 32 weeks diagnosed with PDA, admitted to the HSJ Obstetrics Service. Univariate comparative analysis was performed, and models for predicting the effectiveness of PDA treatment with ibuprofen were explored by multivariate logistic regression analysis. Results: Were included in the study 114 cases and 33 were excluded, with a final sample of 81 PTNB with PDA. The univariable analysis revealed significant differences in the closure efficacy by medical treatment with ibuprofen in several variables, and a multivariate logistic regression model was obtained (discriminative capacity 72.2%, sensitivity 98.1%, specificity 57.1%), considering the effect of gestational age, type of delivery, need for diuretics treatment and platelet transfusion. Conclusion: This study allowed to characterize the population of preterm infants diagnosed with PDA and the identification of a predictive model that can aid to predict the effectiveness to the medical treatment and thus contribute to optimize the medical approach to the non-responders. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-05-12 2020-05-12T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/128681 TID:202613860 |
url |
https://hdl.handle.net/10216/128681 |
identifier_str_mv |
TID:202613860 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135859842220033 |