Circulating miRNAs are associated with the systemic extent of atherosclerosis : novel observations for miR-27b and miR-146

Detalhes bibliográficos
Autor(a) principal: Pereira da Silva, Tiago
Data de Publicação: 2021
Outros Autores: Napoleão, Patricia, Costa, Marina C., Gabriel, André F., Selas, Mafalda, Silva, Filipa, Enguita, Francisco J., Ferreira, Rui Cruz, Carmo, Miguel Mota
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/47015
Resumo: Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Circulating miRNAs are associated with the systemic extent of atherosclerosis : novel observations for miR-27b and miR-146AtherosclerosisCarotid artery diseaseCoronary artery diseaseLower extremity arterial diseasemiRNAmiR-27bmiR-146Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).The mechanisms that regulate the systemic extent of atherosclerosis are not fully understood. We investigated whether the expression of circulating miRNAs is associated with the extent of stable atherosclerosis to a single territory or multiple territories (polyvascular) and with the severity of atherosclerosis in each territory. Ninety-four participants were prospectively recruited and divided into five age- and sex-matched groups: presenting no atherosclerosis, isolated coronary atherosclerosis, coronary and lower extremity atherosclerosis, coronary and carotid atherosclerosis, and atherosclerosis of the coronary, lower extremity, and carotid territories. The expression of six circulating miRNAs with distinct biological roles was assessed. The expression of miR-27b and miR-146 differed across groups (p < 0.05), showing a decrease in the presence of atherosclerosis, particularly in the three territories. miR-27b and miR-146 expression decreased in association with a higher severity of coronary, lower extremity, and carotid atherosclerosis. Polyvascular atherosclerosis involving the three territories was independently associated with a decreased miR-27b and miR-146 expression. Both miRNAs presented an area under the curve of ≥0.75 for predicting polyvascular atherosclerosis involving the three territories. To conclude, miR-27b and miR-146 were associated with the presence of severe polyvascular atherosclerosis and with the atherosclerosis severity in each territory. Both are potential biomarkers of severe systemic atherosclerosis.MDPIRepositório da Universidade de LisboaPereira da Silva, TiagoNapoleão, PatriciaCosta, Marina C.Gabriel, André F.Selas, MafaldaSilva, FilipaEnguita, Francisco J.Ferreira, Rui CruzCarmo, Miguel Mota2021-03-24T13:35:57Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/47015engDiagnostics (Basel). 2021 Feb 16;11(2):318.10.3390/diagnostics110203182075-4418info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:49:37Zoai:repositorio.ul.pt:10451/47015Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:06.669845Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Circulating miRNAs are associated with the systemic extent of atherosclerosis : novel observations for miR-27b and miR-146
title Circulating miRNAs are associated with the systemic extent of atherosclerosis : novel observations for miR-27b and miR-146
spellingShingle Circulating miRNAs are associated with the systemic extent of atherosclerosis : novel observations for miR-27b and miR-146
Pereira da Silva, Tiago
Atherosclerosis
Carotid artery disease
Coronary artery disease
Lower extremity arterial disease
miRNA
miR-27b
miR-146
title_short Circulating miRNAs are associated with the systemic extent of atherosclerosis : novel observations for miR-27b and miR-146
title_full Circulating miRNAs are associated with the systemic extent of atherosclerosis : novel observations for miR-27b and miR-146
title_fullStr Circulating miRNAs are associated with the systemic extent of atherosclerosis : novel observations for miR-27b and miR-146
title_full_unstemmed Circulating miRNAs are associated with the systemic extent of atherosclerosis : novel observations for miR-27b and miR-146
title_sort Circulating miRNAs are associated with the systemic extent of atherosclerosis : novel observations for miR-27b and miR-146
author Pereira da Silva, Tiago
author_facet Pereira da Silva, Tiago
Napoleão, Patricia
Costa, Marina C.
Gabriel, André F.
Selas, Mafalda
Silva, Filipa
Enguita, Francisco J.
Ferreira, Rui Cruz
Carmo, Miguel Mota
author_role author
author2 Napoleão, Patricia
Costa, Marina C.
Gabriel, André F.
Selas, Mafalda
Silva, Filipa
Enguita, Francisco J.
Ferreira, Rui Cruz
Carmo, Miguel Mota
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Pereira da Silva, Tiago
Napoleão, Patricia
Costa, Marina C.
Gabriel, André F.
Selas, Mafalda
Silva, Filipa
Enguita, Francisco J.
Ferreira, Rui Cruz
Carmo, Miguel Mota
dc.subject.por.fl_str_mv Atherosclerosis
Carotid artery disease
Coronary artery disease
Lower extremity arterial disease
miRNA
miR-27b
miR-146
topic Atherosclerosis
Carotid artery disease
Coronary artery disease
Lower extremity arterial disease
miRNA
miR-27b
miR-146
description Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021-03-24T13:35:57Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/47015
url http://hdl.handle.net/10451/47015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Diagnostics (Basel). 2021 Feb 16;11(2):318.
10.3390/diagnostics11020318
2075-4418
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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