Optic neuropathy due to chronic lymphocytic leukemia
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/93192 |
Resumo: | Purpose: Chronic lymphocytic leukemia (CLL) is the most common lymphoproliferative disorder in the western world. The involvement of the central nervous system (CNS) or the optic nerve in CLL, however, is rare. We report a case of a previously untreated patient with CLL whose first manifestation of the disease was a progressive visual loss caused by optic neuropathy. Observations: Clinical manifestations, optical coherence tomography (OCT), and automated visual fields pointed to the diagnosis of neuropathy. Leukemic involvement of the CNS was confirmed after cells suggestive of CLL were found by cerebrospinal fluid analysis. Optic nerve infiltration is thought to be the cause of this optic neuropathy, and the clinical course and treatment are described herein. Conclusions: When readily diagnosed, optic nerve infiltration is a rare, yet manageable complication of CLL. |
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7160 |
spelling |
Optic neuropathy due to chronic lymphocytic leukemiaThe first manifestation of the diseaseChronic lymphocytic leukemiaOptic nerve infiltrationOptic neuropathyOphthalmologyPurpose: Chronic lymphocytic leukemia (CLL) is the most common lymphoproliferative disorder in the western world. The involvement of the central nervous system (CNS) or the optic nerve in CLL, however, is rare. We report a case of a previously untreated patient with CLL whose first manifestation of the disease was a progressive visual loss caused by optic neuropathy. Observations: Clinical manifestations, optical coherence tomography (OCT), and automated visual fields pointed to the diagnosis of neuropathy. Leukemic involvement of the CNS was confirmed after cells suggestive of CLL were found by cerebrospinal fluid analysis. Optic nerve infiltration is thought to be the cause of this optic neuropathy, and the clinical course and treatment are described herein. Conclusions: When readily diagnosed, optic nerve infiltration is a rare, yet manageable complication of CLL.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMaleita, DiogoSerras Pereira, RitaHipolito-Fernandes, DiogoMoura-Coelho, NunoCunha, João PauloTavares Ferreira, Joana2020-02-21T23:54:37Z2020-06-012020-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/93192eng2451-9936PURE: 16971236https://doi.org/10.1016/j.ajoc.2020.100603info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:43:41Zoai:run.unl.pt:10362/93192Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:43:41Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Optic neuropathy due to chronic lymphocytic leukemia The first manifestation of the disease |
title |
Optic neuropathy due to chronic lymphocytic leukemia |
spellingShingle |
Optic neuropathy due to chronic lymphocytic leukemia Maleita, Diogo Chronic lymphocytic leukemia Optic nerve infiltration Optic neuropathy Ophthalmology |
title_short |
Optic neuropathy due to chronic lymphocytic leukemia |
title_full |
Optic neuropathy due to chronic lymphocytic leukemia |
title_fullStr |
Optic neuropathy due to chronic lymphocytic leukemia |
title_full_unstemmed |
Optic neuropathy due to chronic lymphocytic leukemia |
title_sort |
Optic neuropathy due to chronic lymphocytic leukemia |
author |
Maleita, Diogo |
author_facet |
Maleita, Diogo Serras Pereira, Rita Hipolito-Fernandes, Diogo Moura-Coelho, Nuno Cunha, João Paulo Tavares Ferreira, Joana |
author_role |
author |
author2 |
Serras Pereira, Rita Hipolito-Fernandes, Diogo Moura-Coelho, Nuno Cunha, João Paulo Tavares Ferreira, Joana |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Maleita, Diogo Serras Pereira, Rita Hipolito-Fernandes, Diogo Moura-Coelho, Nuno Cunha, João Paulo Tavares Ferreira, Joana |
dc.subject.por.fl_str_mv |
Chronic lymphocytic leukemia Optic nerve infiltration Optic neuropathy Ophthalmology |
topic |
Chronic lymphocytic leukemia Optic nerve infiltration Optic neuropathy Ophthalmology |
description |
Purpose: Chronic lymphocytic leukemia (CLL) is the most common lymphoproliferative disorder in the western world. The involvement of the central nervous system (CNS) or the optic nerve in CLL, however, is rare. We report a case of a previously untreated patient with CLL whose first manifestation of the disease was a progressive visual loss caused by optic neuropathy. Observations: Clinical manifestations, optical coherence tomography (OCT), and automated visual fields pointed to the diagnosis of neuropathy. Leukemic involvement of the CNS was confirmed after cells suggestive of CLL were found by cerebrospinal fluid analysis. Optic nerve infiltration is thought to be the cause of this optic neuropathy, and the clinical course and treatment are described herein. Conclusions: When readily diagnosed, optic nerve infiltration is a rare, yet manageable complication of CLL. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-02-21T23:54:37Z 2020-06-01 2020-06-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/93192 |
url |
http://hdl.handle.net/10362/93192 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2451-9936 PURE: 16971236 https://doi.org/10.1016/j.ajoc.2020.100603 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
_version_ |
1817545728729284608 |