Optic Neuropathy Due to Chronic Lymphocytic Leukemia: the First Manifestation of the Disease
Main Author: | |
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Publication Date: | 2020 |
Other Authors: | , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | http://hdl.handle.net/10400.17/3726 |
Summary: | Purpose: Chronic lymphocytic leukemia (CLL) is the most common lymphoproliferative disorder in the western world. The involvement of the central nervous system (CNS) or the optic nerve in CLL, however, is rare. We report a case of a previously untreated patient with CLL whose first manifestation of the disease was a progressive visual loss caused by optic neuropathy. Observations: Clinical manifestations, optical coherence tomography (OCT), and automated visual fields pointed to the diagnosis of neuropathy. Leukemic involvement of the CNS was confirmed after cells suggestive of CLL were found by cerebrospinal fluid analysis. Optic nerve infiltration is thought to be the cause of this optic neuropathy, and the clinical course and treatment are described herein. Conclusions: When readily diagnosed, optic nerve infiltration is a rare, yet manageable complication of CLL. |
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Optic Neuropathy Due to Chronic Lymphocytic Leukemia: the First Manifestation of the DiseaseCHLC OFTOptic NeuropathyChronic Lymphocytic LeukemiaOptic Nerve InfiltrationPurpose: Chronic lymphocytic leukemia (CLL) is the most common lymphoproliferative disorder in the western world. The involvement of the central nervous system (CNS) or the optic nerve in CLL, however, is rare. We report a case of a previously untreated patient with CLL whose first manifestation of the disease was a progressive visual loss caused by optic neuropathy. Observations: Clinical manifestations, optical coherence tomography (OCT), and automated visual fields pointed to the diagnosis of neuropathy. Leukemic involvement of the CNS was confirmed after cells suggestive of CLL were found by cerebrospinal fluid analysis. Optic nerve infiltration is thought to be the cause of this optic neuropathy, and the clinical course and treatment are described herein. Conclusions: When readily diagnosed, optic nerve infiltration is a rare, yet manageable complication of CLL.ElsevierRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEMaleita, DSerras Pereira, RHipólito-Fernandes, DMoura-Coelho, NCunha, JPTavares Ferreira, J2021-06-15T10:15:09Z2020-062020-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3726engAm J Ophthalmol Case Rep. 2020 Jan 28;18:100603.10.1016/j.ajoc.2020.100603info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:44:04Zoai:repositorio.chlc.min-saude.pt:10400.17/3726Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:21:02.457424Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Optic Neuropathy Due to Chronic Lymphocytic Leukemia: the First Manifestation of the Disease |
title |
Optic Neuropathy Due to Chronic Lymphocytic Leukemia: the First Manifestation of the Disease |
spellingShingle |
Optic Neuropathy Due to Chronic Lymphocytic Leukemia: the First Manifestation of the Disease Maleita, D CHLC OFT Optic Neuropathy Chronic Lymphocytic Leukemia Optic Nerve Infiltration |
title_short |
Optic Neuropathy Due to Chronic Lymphocytic Leukemia: the First Manifestation of the Disease |
title_full |
Optic Neuropathy Due to Chronic Lymphocytic Leukemia: the First Manifestation of the Disease |
title_fullStr |
Optic Neuropathy Due to Chronic Lymphocytic Leukemia: the First Manifestation of the Disease |
title_full_unstemmed |
Optic Neuropathy Due to Chronic Lymphocytic Leukemia: the First Manifestation of the Disease |
title_sort |
Optic Neuropathy Due to Chronic Lymphocytic Leukemia: the First Manifestation of the Disease |
author |
Maleita, D |
author_facet |
Maleita, D Serras Pereira, R Hipólito-Fernandes, D Moura-Coelho, N Cunha, JP Tavares Ferreira, J |
author_role |
author |
author2 |
Serras Pereira, R Hipólito-Fernandes, D Moura-Coelho, N Cunha, JP Tavares Ferreira, J |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Maleita, D Serras Pereira, R Hipólito-Fernandes, D Moura-Coelho, N Cunha, JP Tavares Ferreira, J |
dc.subject.por.fl_str_mv |
CHLC OFT Optic Neuropathy Chronic Lymphocytic Leukemia Optic Nerve Infiltration |
topic |
CHLC OFT Optic Neuropathy Chronic Lymphocytic Leukemia Optic Nerve Infiltration |
description |
Purpose: Chronic lymphocytic leukemia (CLL) is the most common lymphoproliferative disorder in the western world. The involvement of the central nervous system (CNS) or the optic nerve in CLL, however, is rare. We report a case of a previously untreated patient with CLL whose first manifestation of the disease was a progressive visual loss caused by optic neuropathy. Observations: Clinical manifestations, optical coherence tomography (OCT), and automated visual fields pointed to the diagnosis of neuropathy. Leukemic involvement of the CNS was confirmed after cells suggestive of CLL were found by cerebrospinal fluid analysis. Optic nerve infiltration is thought to be the cause of this optic neuropathy, and the clinical course and treatment are described herein. Conclusions: When readily diagnosed, optic nerve infiltration is a rare, yet manageable complication of CLL. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-06 2020-06-01T00:00:00Z 2021-06-15T10:15:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/3726 |
url |
http://hdl.handle.net/10400.17/3726 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Am J Ophthalmol Case Rep. 2020 Jan 28;18:100603. 10.1016/j.ajoc.2020.100603 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799131306527817728 |