Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging

Detalhes bibliográficos
Autor(a) principal: Silva, A. Sofia
Data de Publicação: 2015
Outros Autores: Bonifácio, Vasco, Raje, Vivek, Branco, Paula S., Machado, Paulo Filipe Brito, Correia, Ilídio Joaquim Sobreira, Ricardo, Ana Aguiar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/4667
Resumo: Gold nanoparticles (AuNPs) are the most investigated nanomaterials for theragnosis applications. In a research field where live cell assays, as well as the tracking of nanomaterials into a cell's environment, are of extremely importance, water-soluble AuNPs have been intensively studied to overcome the toxic effects exerted by coatings. Unfortunately, AuNPs fluorescent tagging often fails due to self-quenching and a careful design must be carried out to maintain optoelectronic properties and biocompatibility. In this work, the synthesis of fluorescent gold nanoprobes, able to enter the cell's environment (biotags) and target the cell nucleus, was designed and the particles tracked by confocal laser scanning microscopy. The coating of AuNPs with maleimide poly(ethylene glycol) and fluorescent oligoaziridine biocompatible oligomers, resulted in robust, optically active biotags that open novel insights into cancer theragnosis.
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spelling Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotaggingPEGNanogoldOligoaziridineGold nanoparticles (AuNPs) are the most investigated nanomaterials for theragnosis applications. In a research field where live cell assays, as well as the tracking of nanomaterials into a cell's environment, are of extremely importance, water-soluble AuNPs have been intensively studied to overcome the toxic effects exerted by coatings. Unfortunately, AuNPs fluorescent tagging often fails due to self-quenching and a careful design must be carried out to maintain optoelectronic properties and biocompatibility. In this work, the synthesis of fluorescent gold nanoprobes, able to enter the cell's environment (biotags) and target the cell nucleus, was designed and the particles tracked by confocal laser scanning microscopy. The coating of AuNPs with maleimide poly(ethylene glycol) and fluorescent oligoaziridine biocompatible oligomers, resulted in robust, optically active biotags that open novel insights into cancer theragnosis.Royal Society of ChemistryuBibliorumSilva, A. SofiaBonifácio, VascoRaje, VivekBranco, Paula S.Machado, Paulo Filipe BritoCorreia, Ilídio Joaquim SobreiraRicardo, Ana Aguiar2018-03-20T16:05:43Z2015-01-072015-01-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/4667engSilva, A.S., Bonifácio, V.D.B., Raje, V.P., Branco, P., Machado, P., Correia, I.J. e Aguiar-Ricardo A. (2015) “Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging”, RSC Advances, Vol. 5(14), pp. 10733-1073810.1039/C4RA15743Emetadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-31T02:31:43Zoai:ubibliorum.ubi.pt:10400.6/4667Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:45:43.517304Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging
title Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging
spellingShingle Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging
Silva, A. Sofia
PEG
Nanogold
Oligoaziridine
title_short Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging
title_full Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging
title_fullStr Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging
title_full_unstemmed Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging
title_sort Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging
author Silva, A. Sofia
author_facet Silva, A. Sofia
Bonifácio, Vasco
Raje, Vivek
Branco, Paula S.
Machado, Paulo Filipe Brito
Correia, Ilídio Joaquim Sobreira
Ricardo, Ana Aguiar
author_role author
author2 Bonifácio, Vasco
Raje, Vivek
Branco, Paula S.
Machado, Paulo Filipe Brito
Correia, Ilídio Joaquim Sobreira
Ricardo, Ana Aguiar
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Silva, A. Sofia
Bonifácio, Vasco
Raje, Vivek
Branco, Paula S.
Machado, Paulo Filipe Brito
Correia, Ilídio Joaquim Sobreira
Ricardo, Ana Aguiar
dc.subject.por.fl_str_mv PEG
Nanogold
Oligoaziridine
topic PEG
Nanogold
Oligoaziridine
description Gold nanoparticles (AuNPs) are the most investigated nanomaterials for theragnosis applications. In a research field where live cell assays, as well as the tracking of nanomaterials into a cell's environment, are of extremely importance, water-soluble AuNPs have been intensively studied to overcome the toxic effects exerted by coatings. Unfortunately, AuNPs fluorescent tagging often fails due to self-quenching and a careful design must be carried out to maintain optoelectronic properties and biocompatibility. In this work, the synthesis of fluorescent gold nanoprobes, able to enter the cell's environment (biotags) and target the cell nucleus, was designed and the particles tracked by confocal laser scanning microscopy. The coating of AuNPs with maleimide poly(ethylene glycol) and fluorescent oligoaziridine biocompatible oligomers, resulted in robust, optically active biotags that open novel insights into cancer theragnosis.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-07
2015-01-07T00:00:00Z
2018-03-20T16:05:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/4667
url http://hdl.handle.net/10400.6/4667
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Silva, A.S., Bonifácio, V.D.B., Raje, V.P., Branco, P., Machado, P., Correia, I.J. e Aguiar-Ricardo A. (2015) “Design of oligoaziridine-PEG coatings for efficient nanogold cellular biotagging”, RSC Advances, Vol. 5(14), pp. 10733-10738
10.1039/C4RA15743E
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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