Nanogold POxylation: towards always-on fluorescent lung cancer targeting

Detalhes bibliográficos
Autor(a) principal: Silva, A. Sofia
Data de Publicação: 2016
Outros Autores: Silva, Marta, Miguel, Sónia P., Bonifácio, Vasco, Correia, Ilídio Joaquim Sobreira, Ricardo, Ana Aguiar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/4682
Resumo: Gold nanoparticles (GNPs) are one of most investigated nanomaterials for lung cancer diagnosis and therapy (theragnosis). For imaging purposes, GNPs are often tagged with fluorescent probes, but unfortunately the associated plasmon resonance effect leads to fluorescence self-quenching, thus precluding accurate localization. In this study, biocompatible GNPs targeted with a laminin fragment were successfully engineered using fluorescent oligo-oxazolines produced in supercritical carbon dioxide. The architecture and properties of the POxylated constructs were fully characterized and confocal laser scanning microscopy measurements demonstrated a higher cellular uptake into A549 lung cancer cells through an active targeting mechanism.
id RCAP_c9286621753ebdaf5485e676a5a7fecd
oai_identifier_str oai:ubibliorum.ubi.pt:10400.6/4682
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Nanogold POxylation: towards always-on fluorescent lung cancer targetingNanogoldPOxylationLung cancerGold nanoparticles (GNPs) are one of most investigated nanomaterials for lung cancer diagnosis and therapy (theragnosis). For imaging purposes, GNPs are often tagged with fluorescent probes, but unfortunately the associated plasmon resonance effect leads to fluorescence self-quenching, thus precluding accurate localization. In this study, biocompatible GNPs targeted with a laminin fragment were successfully engineered using fluorescent oligo-oxazolines produced in supercritical carbon dioxide. The architecture and properties of the POxylated constructs were fully characterized and confocal laser scanning microscopy measurements demonstrated a higher cellular uptake into A549 lung cancer cells through an active targeting mechanism.Royal Society of ChemistryuBibliorumSilva, A. SofiaSilva, MartaMiguel, Sónia P.Bonifácio, VascoCorreia, Ilídio Joaquim SobreiraRicardo, Ana Aguiar2018-03-21T11:48:50Z2016-03-282016-03-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/4682engSilva, A. S., Silva, M. C., Miguel, S. P., Bonifácio, V. D., Correia, I. J., e Aguiar-Ricardo, A. (2016) “Nanogold POxylation: towards always-on fluorescent lung cancer targeting.” RSC Advances, Vol.6 (40), pp. 33631-3363510.1039/C6RA00532Bmetadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-27T12:15:09Zoai:ubibliorum.ubi.pt:10400.6/4682Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-27T12:15:09Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nanogold POxylation: towards always-on fluorescent lung cancer targeting
title Nanogold POxylation: towards always-on fluorescent lung cancer targeting
spellingShingle Nanogold POxylation: towards always-on fluorescent lung cancer targeting
Silva, A. Sofia
Nanogold
POxylation
Lung cancer
title_short Nanogold POxylation: towards always-on fluorescent lung cancer targeting
title_full Nanogold POxylation: towards always-on fluorescent lung cancer targeting
title_fullStr Nanogold POxylation: towards always-on fluorescent lung cancer targeting
title_full_unstemmed Nanogold POxylation: towards always-on fluorescent lung cancer targeting
title_sort Nanogold POxylation: towards always-on fluorescent lung cancer targeting
author Silva, A. Sofia
author_facet Silva, A. Sofia
Silva, Marta
Miguel, Sónia P.
Bonifácio, Vasco
Correia, Ilídio Joaquim Sobreira
Ricardo, Ana Aguiar
author_role author
author2 Silva, Marta
Miguel, Sónia P.
Bonifácio, Vasco
Correia, Ilídio Joaquim Sobreira
Ricardo, Ana Aguiar
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Silva, A. Sofia
Silva, Marta
Miguel, Sónia P.
Bonifácio, Vasco
Correia, Ilídio Joaquim Sobreira
Ricardo, Ana Aguiar
dc.subject.por.fl_str_mv Nanogold
POxylation
Lung cancer
topic Nanogold
POxylation
Lung cancer
description Gold nanoparticles (GNPs) are one of most investigated nanomaterials for lung cancer diagnosis and therapy (theragnosis). For imaging purposes, GNPs are often tagged with fluorescent probes, but unfortunately the associated plasmon resonance effect leads to fluorescence self-quenching, thus precluding accurate localization. In this study, biocompatible GNPs targeted with a laminin fragment were successfully engineered using fluorescent oligo-oxazolines produced in supercritical carbon dioxide. The architecture and properties of the POxylated constructs were fully characterized and confocal laser scanning microscopy measurements demonstrated a higher cellular uptake into A549 lung cancer cells through an active targeting mechanism.
publishDate 2016
dc.date.none.fl_str_mv 2016-03-28
2016-03-28T00:00:00Z
2018-03-21T11:48:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/4682
url http://hdl.handle.net/10400.6/4682
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Silva, A. S., Silva, M. C., Miguel, S. P., Bonifácio, V. D., Correia, I. J., e Aguiar-Ricardo, A. (2016) “Nanogold POxylation: towards always-on fluorescent lung cancer targeting.” RSC Advances, Vol.6 (40), pp. 33631-33635
10.1039/C6RA00532B
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817549604312317952

Registros relacionados