Evaluation of parasite and host phenolic composition and bioactivities − The practical case of Cytinus hypocistis (L.) L. and Halimium lasianthum (Lam.) Greuter
Main Author: | |
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Publication Date: | 2018 |
Other Authors: | , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | http://hdl.handle.net/10198/24524 |
Summary: | Cytinus hypocistis (L.) L. is a comestible holoparasite with great potential for cosmeceutical application. Although its high tannin content has been associated with its bioactive and inhibitory enzyme properties, this is the first report establishing a relationship between parasite and host (Halimium lasianthum (Lam.) Greuter) phenolic profile and bioactive properties. Thus, five extracts (aerial and root extracts of non-parasited and parasited H. lasianthum and C. hypocistis) were evaluated. The tentative identification of both species comprises 39 phenolic compounds. Hydrolysable tannins and flavonoids were the main identified groups in C. hypocistis and H. lasianthum extracts, respectively. Regarding bioactivities, C. hypocistis exhibited excellent antioxidant results both in Oxidative Haemolysis (OxHLIA) and inhibition of Thiobarbituric Acid Reactive Substances Formation (TBARS). The tested extracts presented antimicrobial inhibition, anti-inflammatory activity, and effective cytotoxicity against tumour cells. C. hypocistis exhibited the lowest cytotoxicity on a non-tumour cell line. Principal Component Analysis (PCA) was a suitable approach to analyse differences among samples, explaining up to 67% of data variability and suggesting no similarities between parasite and host phenolic composition and bioactivities. Therefore, this comparative study emphasises the significance of both species as a source of biologically active compounds. |
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Evaluation of parasite and host phenolic composition and bioactivities − The practical case of Cytinus hypocistis (L.) L. and Halimium lasianthum (Lam.) GreuterAntimicrobialAntioxidantCytotoxicityFlavonoidsTanninsTyrosinase inhibitionCytinus hypocistis (L.) L. is a comestible holoparasite with great potential for cosmeceutical application. Although its high tannin content has been associated with its bioactive and inhibitory enzyme properties, this is the first report establishing a relationship between parasite and host (Halimium lasianthum (Lam.) Greuter) phenolic profile and bioactive properties. Thus, five extracts (aerial and root extracts of non-parasited and parasited H. lasianthum and C. hypocistis) were evaluated. The tentative identification of both species comprises 39 phenolic compounds. Hydrolysable tannins and flavonoids were the main identified groups in C. hypocistis and H. lasianthum extracts, respectively. Regarding bioactivities, C. hypocistis exhibited excellent antioxidant results both in Oxidative Haemolysis (OxHLIA) and inhibition of Thiobarbituric Acid Reactive Substances Formation (TBARS). The tested extracts presented antimicrobial inhibition, anti-inflammatory activity, and effective cytotoxicity against tumour cells. C. hypocistis exhibited the lowest cytotoxicity on a non-tumour cell line. Principal Component Analysis (PCA) was a suitable approach to analyse differences among samples, explaining up to 67% of data variability and suggesting no similarities between parasite and host phenolic composition and bioactivities. Therefore, this comparative study emphasises the significance of both species as a source of biologically active compounds.The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020). A. R. Silva is grateful to FCT and FSE for her Doctoral Grant (SFRH/BD/145834/2019). L. Barros, C. Pereira, I. Dias, and R. C. Calhelha are grateful to F.C.T. and P.I. for their contracts through the institutional scientific employment programme. The authors are also thankful to the FEDER-Interreg Espa˜na-Portugal programme for financial support through the project TRANSCoLAB: 0612_TRANS_CO_LAB_2_P and to ERDF through the Regional Operational Program North 2020, within the scope of the Project GreenHealth - Norte-01–0145-FEDER-000042. This research was also funded by the Serbian Ministry of Education, Science and Technological Development (Contract No. 451–03-9/2021–14/200007).Biblioteca Digital do IPBSilva, Ana RitaAyuso, ManuelPereira, CarlaDias, Maria InêsKostić, MarinaCalhelha, Ricardo C.Soković, MarinaGarcía, Pablo A.Ferreira, Isabel C.F.R.Barros, Lillian2018-01-19T10:00:00Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/24524engSilva, Ana Rita; Ayuso, Manuel; Pereira, Carla; Dias, Maria Inês; Kostić , Marina; Calhelha, Ricardo C.; Soković , Marina; García, Pablo A.; Ferreira, Isabel C.F.R.; Barros, Lillian (2022). Evaluation of parasite and host phenolic composition and bioactivities − The practical case of Cytinus hypocistis (L.) L. and Halimium lasianthum (Lam.) Greuter. Industrial Crops and Products. ISSN 0926-6690. 176, p. 1-100926-669010.1016/j.indcrop.2021.114343info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:55:12Zoai:bibliotecadigital.ipb.pt:10198/24524Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:15:28.578209Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Evaluation of parasite and host phenolic composition and bioactivities − The practical case of Cytinus hypocistis (L.) L. and Halimium lasianthum (Lam.) Greuter |
title |
Evaluation of parasite and host phenolic composition and bioactivities − The practical case of Cytinus hypocistis (L.) L. and Halimium lasianthum (Lam.) Greuter |
spellingShingle |
Evaluation of parasite and host phenolic composition and bioactivities − The practical case of Cytinus hypocistis (L.) L. and Halimium lasianthum (Lam.) Greuter Silva, Ana Rita Antimicrobial Antioxidant Cytotoxicity Flavonoids Tannins Tyrosinase inhibition |
title_short |
Evaluation of parasite and host phenolic composition and bioactivities − The practical case of Cytinus hypocistis (L.) L. and Halimium lasianthum (Lam.) Greuter |
title_full |
Evaluation of parasite and host phenolic composition and bioactivities − The practical case of Cytinus hypocistis (L.) L. and Halimium lasianthum (Lam.) Greuter |
title_fullStr |
Evaluation of parasite and host phenolic composition and bioactivities − The practical case of Cytinus hypocistis (L.) L. and Halimium lasianthum (Lam.) Greuter |
title_full_unstemmed |
Evaluation of parasite and host phenolic composition and bioactivities − The practical case of Cytinus hypocistis (L.) L. and Halimium lasianthum (Lam.) Greuter |
title_sort |
Evaluation of parasite and host phenolic composition and bioactivities − The practical case of Cytinus hypocistis (L.) L. and Halimium lasianthum (Lam.) Greuter |
author |
Silva, Ana Rita |
author_facet |
Silva, Ana Rita Ayuso, Manuel Pereira, Carla Dias, Maria Inês Kostić, Marina Calhelha, Ricardo C. Soković, Marina García, Pablo A. Ferreira, Isabel C.F.R. Barros, Lillian |
author_role |
author |
author2 |
Ayuso, Manuel Pereira, Carla Dias, Maria Inês Kostić, Marina Calhelha, Ricardo C. Soković, Marina García, Pablo A. Ferreira, Isabel C.F.R. Barros, Lillian |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Silva, Ana Rita Ayuso, Manuel Pereira, Carla Dias, Maria Inês Kostić, Marina Calhelha, Ricardo C. Soković, Marina García, Pablo A. Ferreira, Isabel C.F.R. Barros, Lillian |
dc.subject.por.fl_str_mv |
Antimicrobial Antioxidant Cytotoxicity Flavonoids Tannins Tyrosinase inhibition |
topic |
Antimicrobial Antioxidant Cytotoxicity Flavonoids Tannins Tyrosinase inhibition |
description |
Cytinus hypocistis (L.) L. is a comestible holoparasite with great potential for cosmeceutical application. Although its high tannin content has been associated with its bioactive and inhibitory enzyme properties, this is the first report establishing a relationship between parasite and host (Halimium lasianthum (Lam.) Greuter) phenolic profile and bioactive properties. Thus, five extracts (aerial and root extracts of non-parasited and parasited H. lasianthum and C. hypocistis) were evaluated. The tentative identification of both species comprises 39 phenolic compounds. Hydrolysable tannins and flavonoids were the main identified groups in C. hypocistis and H. lasianthum extracts, respectively. Regarding bioactivities, C. hypocistis exhibited excellent antioxidant results both in Oxidative Haemolysis (OxHLIA) and inhibition of Thiobarbituric Acid Reactive Substances Formation (TBARS). The tested extracts presented antimicrobial inhibition, anti-inflammatory activity, and effective cytotoxicity against tumour cells. C. hypocistis exhibited the lowest cytotoxicity on a non-tumour cell line. Principal Component Analysis (PCA) was a suitable approach to analyse differences among samples, explaining up to 67% of data variability and suggesting no similarities between parasite and host phenolic composition and bioactivities. Therefore, this comparative study emphasises the significance of both species as a source of biologically active compounds. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-19T10:00:00Z 2022 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/24524 |
url |
http://hdl.handle.net/10198/24524 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Silva, Ana Rita; Ayuso, Manuel; Pereira, Carla; Dias, Maria Inês; Kostić , Marina; Calhelha, Ricardo C.; Soković , Marina; García, Pablo A.; Ferreira, Isabel C.F.R.; Barros, Lillian (2022). Evaluation of parasite and host phenolic composition and bioactivities − The practical case of Cytinus hypocistis (L.) L. and Halimium lasianthum (Lam.) Greuter. Industrial Crops and Products. ISSN 0926-6690. 176, p. 1-10 0926-6690 10.1016/j.indcrop.2021.114343 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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