Genetic competence drives genome diversity in Bacillus subtilis

Detalhes bibliográficos
Autor(a) principal: Brito, Patrícia H
Data de Publicação: 2018
Outros Autores: Chevreux, Bastien, Serra, Cláudia R, Schyns, Ghislain, Henriques, Adriano O, Pereira-Leal, José B
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/32936
Resumo: © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
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spelling Genetic competence drives genome diversity in Bacillus subtilisBacillus subtilispangenomecomparative genomicsbacterial genome evolutionlateral gene transfergenetic competenceSDG 14 - Life Below Water© The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.Prokaryote genomes are the result of a dynamic flux of genes, with increases achieved via horizontal gene transfer and reductions occurring through gene loss. The ecological and selective forces that drive this genomic flexibility vary across species. Bacillus subtilis is a naturally competent bacterium that occupies various environments, including plant-associated, soil, and marine niches, and the gut of both invertebrates and vertebrates. Here, we quantify the genomic diversity of B. subtilis and infer the genome dynamics that explain the high genetic and phenotypic diversity observed. Phylogenomic and comparative genomic analyses of 42 B. subtilis genomes uncover a remarkable genome diversity that translates into a core genome of 1659 genes and an asymptotic pangenome growth rate of 57 new genes per new genome added. This diversity is due to a large proportion of low-frequency genes that are acquired from closely related species. We find no gene-loss bias among wild isolates, which explains why the cloud genome, 43% of the species pangenome, represents only a small proportion of each genome. We show that B. subtilis can acquire xenologous copies of core genes that propagate laterally among strains within a niche. While not excluding the contributions of other mechanisms, our results strongly suggest a process of gene acquisition that is largely driven by competence, where the long-term maintenance of acquired genes depends on local and global fitness effects. This competence-driven genomic diversity provides B. subtilis with its generalist character, enabling it to occupy a wide range of ecological niches and cycle through them.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNBrito, Patrícia HChevreux, BastienSerra, Cláudia RSchyns, GhislainHenriques, Adriano OPereira-Leal, José B2018-03-20T23:13:46Z2018-012018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17application/pdfhttp://hdl.handle.net/10362/32936engPURE: 3409545https://doi.org/10.1093/gbe/evx270info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:18:14Zoai:run.unl.pt:10362/32936Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:29:56.762395Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Genetic competence drives genome diversity in Bacillus subtilis
title Genetic competence drives genome diversity in Bacillus subtilis
spellingShingle Genetic competence drives genome diversity in Bacillus subtilis
Brito, Patrícia H
Bacillus subtilis
pangenome
comparative genomics
bacterial genome evolution
lateral gene transfer
genetic competence
SDG 14 - Life Below Water
title_short Genetic competence drives genome diversity in Bacillus subtilis
title_full Genetic competence drives genome diversity in Bacillus subtilis
title_fullStr Genetic competence drives genome diversity in Bacillus subtilis
title_full_unstemmed Genetic competence drives genome diversity in Bacillus subtilis
title_sort Genetic competence drives genome diversity in Bacillus subtilis
author Brito, Patrícia H
author_facet Brito, Patrícia H
Chevreux, Bastien
Serra, Cláudia R
Schyns, Ghislain
Henriques, Adriano O
Pereira-Leal, José B
author_role author
author2 Chevreux, Bastien
Serra, Cláudia R
Schyns, Ghislain
Henriques, Adriano O
Pereira-Leal, José B
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Brito, Patrícia H
Chevreux, Bastien
Serra, Cláudia R
Schyns, Ghislain
Henriques, Adriano O
Pereira-Leal, José B
dc.subject.por.fl_str_mv Bacillus subtilis
pangenome
comparative genomics
bacterial genome evolution
lateral gene transfer
genetic competence
SDG 14 - Life Below Water
topic Bacillus subtilis
pangenome
comparative genomics
bacterial genome evolution
lateral gene transfer
genetic competence
SDG 14 - Life Below Water
description © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
publishDate 2018
dc.date.none.fl_str_mv 2018-03-20T23:13:46Z
2018-01
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/32936
url http://hdl.handle.net/10362/32936
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PURE: 3409545
https://doi.org/10.1093/gbe/evx270
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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