Genetic Competence Drives Genome Diversity in Bacillus subtilis

Detalhes bibliográficos
Autor(a) principal: Brito, Patrícia H
Data de Publicação: 2018
Outros Autores: Chevreux, Bastien, Serra, Cláudia R, Schyns, Ghislain, Henriques, Adriano O, Pereira-Leal, José B
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/822
Resumo: This deposit is composed by the main article plus the supplementary materials of the publication.
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spelling Genetic Competence Drives Genome Diversity in Bacillus subtilisBacillus subtilispangenomecomparative genomicsbacterial genome evolutionlateral gene transfergenetic competenceThis deposit is composed by the main article plus the supplementary materials of the publication.Prokaryote genomes are the result of a dynamic flux of genes, with increases achieved via horizontal gene transfer and reductions occurring through gene loss. The ecological and selective forces that drive this genomic flexibility vary across species. Bacillus subtilis is a naturally competent bacterium that occupies various environments, including plant-associated, soil, and marine niches, and the gut of both invertebrates and vertebrates. Here, we quantify the genomic diversity of B. subtilis and infer the genome dynamics that explain the high genetic and phenotypic diversity observed. Phylogenomic and comparative genomic analyses of 42 B. subtilis genomes uncover a remarkable genome diversity that translates into a core genome of 1,659 genes and an asymptotic pangenome growth rate of 57 new genes per new genome added. This diversity is due to a large proportion of low-frequency genes that are acquired from closely related species. We find no gene-loss bias among wild isolates, which explains why the cloud genome, 43% of the species pangenome, represents only a small proportion of each genome. We show that B. subtilis can acquire xenologous copies of core genes that propagate laterally among strains within a niche. While not excluding the contributions of other mechanisms, our results strongly suggest a process of gene acquisition that is largely driven by competence, where the long-term maintenance of acquired genes depends on local and global fitness effects. This competence-driven genomic diversity provides B. subtilis with its generalist character, enabling it to occupy a wide range of ecological niches and cycle through them.Fundação para a Ciência e a Tecnologia grants: (PTDC/EBB-BIO/119006/2010, PEst-OE/EQB/LA0004/2011, SFRH/BPD/89907/2012, SFRH/BD/29397/06); FEDER grant: (LISBOA-01-0145-FEDER-007660).Oxford University PressARCABrito, Patrícia HChevreux, BastienSerra, Cláudia RSchyns, GhislainHenriques, Adriano OPereira-Leal, José B2018-01-24T18:22:10Z2018-01-202018-01-20T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheetapplication/pdfapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheethttp://hdl.handle.net/10400.7/822engPatrícia H Brito, Bastien Chevreux, Cláudia R Serra, Ghislain Schyns, Adriano O Henriques, José B Pereira-Leal; Genetic Competence Drives Genome Diversity in Bacillus subtilis, Genome Biology and Evolution, Volume 10, Issue 1, 1 January 2018, Pages 108–124, https://doi.org/10.1093/gbe/evx27010.1093/gbe/evx270info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:13Zoai:arca.igc.gulbenkian.pt:10400.7/822Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:02.601953Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Genetic Competence Drives Genome Diversity in Bacillus subtilis
title Genetic Competence Drives Genome Diversity in Bacillus subtilis
spellingShingle Genetic Competence Drives Genome Diversity in Bacillus subtilis
Brito, Patrícia H
Bacillus subtilis
pangenome
comparative genomics
bacterial genome evolution
lateral gene transfer
genetic competence
title_short Genetic Competence Drives Genome Diversity in Bacillus subtilis
title_full Genetic Competence Drives Genome Diversity in Bacillus subtilis
title_fullStr Genetic Competence Drives Genome Diversity in Bacillus subtilis
title_full_unstemmed Genetic Competence Drives Genome Diversity in Bacillus subtilis
title_sort Genetic Competence Drives Genome Diversity in Bacillus subtilis
author Brito, Patrícia H
author_facet Brito, Patrícia H
Chevreux, Bastien
Serra, Cláudia R
Schyns, Ghislain
Henriques, Adriano O
Pereira-Leal, José B
author_role author
author2 Chevreux, Bastien
Serra, Cláudia R
Schyns, Ghislain
Henriques, Adriano O
Pereira-Leal, José B
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Brito, Patrícia H
Chevreux, Bastien
Serra, Cláudia R
Schyns, Ghislain
Henriques, Adriano O
Pereira-Leal, José B
dc.subject.por.fl_str_mv Bacillus subtilis
pangenome
comparative genomics
bacterial genome evolution
lateral gene transfer
genetic competence
topic Bacillus subtilis
pangenome
comparative genomics
bacterial genome evolution
lateral gene transfer
genetic competence
description This deposit is composed by the main article plus the supplementary materials of the publication.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-24T18:22:10Z
2018-01-20
2018-01-20T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/822
url http://hdl.handle.net/10400.7/822
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Patrícia H Brito, Bastien Chevreux, Cláudia R Serra, Ghislain Schyns, Adriano O Henriques, José B Pereira-Leal; Genetic Competence Drives Genome Diversity in Bacillus subtilis, Genome Biology and Evolution, Volume 10, Issue 1, 1 January 2018, Pages 108–124, https://doi.org/10.1093/gbe/evx270
10.1093/gbe/evx270
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
application/pdf
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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