Preservation of catechin antioxidant properties loaded in carbohydrate nanoparticles

Detalhes bibliográficos
Autor(a) principal: Peres, Ivone
Data de Publicação: 2011
Outros Autores: Rocha, Sandra, Gomes, Joana, Morais, Simone, Pereira, Maria do Carmo, Coelho, Manuel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/3045
Resumo: Epigallocatechin gallate (EGCG), an antioxidant with several pharmacological and biological activities, was encapsulated in carbohydrate particles to preserve its antioxidant properties and improve its bioavailability. Gum arabic–maltodextrin particles loaded with EGCG (EGCG/P) were successfully produced by homogenization and spray-drying, with an EGCG loading efficiency of 96 ± 3%. Spray-dried particles are spherical or corrugated and polydisperse with diameters less than 20 m. The particles in aqueous suspension revealed two main populations, with mean average diameters of 40 nm and 400 nm. Attenuated total reflection-infrared spectroscopy (ATR-IR) confirmed that EGCG was incorporated in the carbohydrate matrix by intermolecular interactions, maintaining its chemical integrity. Atomic force microscopy imaging proved the particle spherical shape and size. The present study demonstrates that the carbohydrate matrix is able to preserve EGCG antioxidant properties, as proof of concept to be used as polymeric drug carrier.
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spelling Preservation of catechin antioxidant properties loaded in carbohydrate nanoparticlesEpigallocatechin gallateCarbohydratesParticlesSpray-dryingPolymeric drug carrierEpigallocatechin gallate (EGCG), an antioxidant with several pharmacological and biological activities, was encapsulated in carbohydrate particles to preserve its antioxidant properties and improve its bioavailability. Gum arabic–maltodextrin particles loaded with EGCG (EGCG/P) were successfully produced by homogenization and spray-drying, with an EGCG loading efficiency of 96 ± 3%. Spray-dried particles are spherical or corrugated and polydisperse with diameters less than 20 m. The particles in aqueous suspension revealed two main populations, with mean average diameters of 40 nm and 400 nm. Attenuated total reflection-infrared spectroscopy (ATR-IR) confirmed that EGCG was incorporated in the carbohydrate matrix by intermolecular interactions, maintaining its chemical integrity. Atomic force microscopy imaging proved the particle spherical shape and size. The present study demonstrates that the carbohydrate matrix is able to preserve EGCG antioxidant properties, as proof of concept to be used as polymeric drug carrier.ElsevierRepositório Científico do Instituto Politécnico do PortoPeres, IvoneRocha, SandraGomes, JoanaMorais, SimonePereira, Maria do CarmoCoelho, Manuel2013-11-29T16:01:18Z20112011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/3045eng0144-861710.1016/j.carbpol.2011.04.029metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:42:43Zoai:recipp.ipp.pt:10400.22/3045Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:24:02.339348Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Preservation of catechin antioxidant properties loaded in carbohydrate nanoparticles
title Preservation of catechin antioxidant properties loaded in carbohydrate nanoparticles
spellingShingle Preservation of catechin antioxidant properties loaded in carbohydrate nanoparticles
Peres, Ivone
Epigallocatechin gallate
Carbohydrates
Particles
Spray-drying
Polymeric drug carrier
title_short Preservation of catechin antioxidant properties loaded in carbohydrate nanoparticles
title_full Preservation of catechin antioxidant properties loaded in carbohydrate nanoparticles
title_fullStr Preservation of catechin antioxidant properties loaded in carbohydrate nanoparticles
title_full_unstemmed Preservation of catechin antioxidant properties loaded in carbohydrate nanoparticles
title_sort Preservation of catechin antioxidant properties loaded in carbohydrate nanoparticles
author Peres, Ivone
author_facet Peres, Ivone
Rocha, Sandra
Gomes, Joana
Morais, Simone
Pereira, Maria do Carmo
Coelho, Manuel
author_role author
author2 Rocha, Sandra
Gomes, Joana
Morais, Simone
Pereira, Maria do Carmo
Coelho, Manuel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Peres, Ivone
Rocha, Sandra
Gomes, Joana
Morais, Simone
Pereira, Maria do Carmo
Coelho, Manuel
dc.subject.por.fl_str_mv Epigallocatechin gallate
Carbohydrates
Particles
Spray-drying
Polymeric drug carrier
topic Epigallocatechin gallate
Carbohydrates
Particles
Spray-drying
Polymeric drug carrier
description Epigallocatechin gallate (EGCG), an antioxidant with several pharmacological and biological activities, was encapsulated in carbohydrate particles to preserve its antioxidant properties and improve its bioavailability. Gum arabic–maltodextrin particles loaded with EGCG (EGCG/P) were successfully produced by homogenization and spray-drying, with an EGCG loading efficiency of 96 ± 3%. Spray-dried particles are spherical or corrugated and polydisperse with diameters less than 20 m. The particles in aqueous suspension revealed two main populations, with mean average diameters of 40 nm and 400 nm. Attenuated total reflection-infrared spectroscopy (ATR-IR) confirmed that EGCG was incorporated in the carbohydrate matrix by intermolecular interactions, maintaining its chemical integrity. Atomic force microscopy imaging proved the particle spherical shape and size. The present study demonstrates that the carbohydrate matrix is able to preserve EGCG antioxidant properties, as proof of concept to be used as polymeric drug carrier.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-01-01T00:00:00Z
2013-11-29T16:01:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/3045
url http://hdl.handle.net/10400.22/3045
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0144-8617
10.1016/j.carbpol.2011.04.029
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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